Acid sensors in the gut: A taste of things to come

European Journal of Gastroenterology and Hepatology

Volumn 13, Issue 8, 2001, Pages 885-888

  Aziz, Qasim ^a  

^a HOPE HOSPITAL   (United Kingdom)

Author keywords

Acid; Gastrointestinal tract; Inflammation; Ion channels; Pain; Peripheral and central sensitization; Visceral

Indexed keywords

ION CHANNEL;

BRAIN CORTEX; GASTROINTESTINAL DISEASE; HYPERSENSITIVITY; INFLAMMATION; MOLECULAR BIOLOGY; NERVE CELL; NERVE INJURY; NOCICEPTION; PRIORITY JOURNAL; PROTEIN PROCESSING; REVIEW; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; STIMULUS RESPONSE; STOMACH INNERVATION; STOMACH PAIN; STOMACH PH; TISSUE INJURY; VISCERAL PAIN;

ANIMALS; HUMANS; HYDROGEN-ION CONCENTRATION; INFLAMMATION; INTESTINES; MEMBRANE PROTEINS; NERVE TISSUE PROTEINS; NEURAL PATHWAYS; NOCICEPTORS; PAIN; POSTERIOR HORN CELLS; RECEPTORS, DRUG; SIGNAL TRANSDUCTION; SODIUM CHANNELS; SYNAPTIC TRANSMISSION;

EID: 0034879432     PISSN: 0954691X     EISSN: 14735687     Source Type: Journal    
DOI: 10.1097/00042737-200108000-00001     Document Type: Article

References (27)

1. Besson JM. The neurobiology of pain. Lancet 1999; 353: 9164-9165.
2. Woolf CJ, Salter MW. Neuronal plasticity: Increasing the gain in pain. Science 2000; 288: 5472-5479.
3. Woolf CJ, Costigan M. Transcriptional and posttranslational plasticity and the generation of inflammatory pain. Proc Natl Acad Sci USA 1999; 96: 14-30.
4. Woolf CJ, Mannion RJ. Neuropathic pain: Aetiology, symptoms, mechanisms, and management. Lancet 1999; 353 (9168): 1959-1964.
5. Levine JD, Fields HL, Basbaum AI. Peptides and the primary afferent nociceptor. J Neuroscience 1993; 13: 2273-2286.
6. A receptor-mediated IPSCs in identified lamina I neurons of the adult rat spinal cord. J Neurosci 1999; 19: 7342-7355.
7. Cervero F, Laird JM. Visceral pain. Lancet 1999; 353: 9170-9178.
8. Gebhart GF. Pathobiology of visceral pain: molecular mechanisms and therapeutic implications IV. Visceral afferent contributions to the pathobiology of visceral pain. Am J Physiol Gastrointest Liver Physiol 2000; 278: G834-G838.
9. Bueno L, Fioramonti J, Garcia VR. Pathobiology of visceral pain: molecular mechanisms and therapeutic implications III. Visceral afferent pathways: A source of new therapeutic targets for abdominal pain. Am J Physiol Gastrointest Liver Physiol 2000; 278: G670-G676.
10. Wood JN. Pathobiology of visceral pain: molecular mechanisms and therapeutic implications II. Genetic approaches to pain therapy. Am J Physiol Gastrointest Liver Physiol 2000; 278: G507-G512.
11. Isom LL. Pathobiology of visceral pain: molecular mechanisms and therapeutic implications I. Cellular and molecular biology of sodium channel β-subunits: Therapeutic implications for pain? Am J Physiol Gastrointest Liver Physiol 2000; 278: G349-G353.
12. Bueno L, Fioramonti J. Effects of inflammatory mediators on gut sensitivity. Can J Gastroenterol 1999; 13 (suppl A): 42A-46A.
13. Bueno L, Fioramonti J, Delvaux M, Frexinos J. Mediators and pharmacology of visceral sensitivity: From basic to clinical investigations. Gastroenterology 1997; 112: 1714-1743.
14. Al-Chaer E, Kawasaki M, Pasricha P. A new model of chronic visceral hypersensitivity in adult rats induced by colon irritation during postnatal development. Gastroenterology 2000; 119: 1276-1285.
15. Mayer EA, Gebhart GF. Basic and clinical aspects of visceral hyperalgesia. Gastroenterology 2000; 107: 271-293.
16. Gwee KA, Leong YL, Graham C, McKendrick MW, Collins SM, Walters SJ. et al. The role of psychological and biological factors in postinfective gut dysfunction. Gut 1999; 44: 400-406.
17. Sarkar S, Aziz Q, Woolf CJ, Thompson DG. Central sensitization may contribute to the development of noncardiac chest pain. Lancet 2000; 356: 1154-1159.
18. + channel specific for sensory neurons. J Biol Chem 1997; 272: 20975-20978.
19. Yiangou Y, Facer P, Dyer NHC, Chan CL, Knowles C, Williams NS, Anand P. Vanilloid receptor 1 immunoreactivity in inflamed human bowel. Lancet 2001; 357 (9265): 1338-1339.
20. Yiangou Y, Facer P, Smith JAM, Sangameswaran L, Eglen R, Birch R. et al. Increased acid-sensing ion channel ASIC-3 in inflamed human intestine. Eur J Gastroenterol Hepatol 2001; 13: 891-896.
21. Chen CC, England S, Akopian AN, Wood JN. A sensory neuron-specific, proton-gated ion channel. Proc Natl Acad Sci USA 1998; 95: 17-25.
22. Lingueglia E, de Weille JR, Bassilana F, Heurteaux C, Sakai H, Waldmann R, Lazdunski M. A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells. J Biol Chem 1997; 272: 47-83.
23. Olson TH, Riedl MS, Vulchanova L, Ortiz-Gonzalez XR, Elde R. An acid sensing ion channel (ASIC) localizes to small primary afferent neurons in rats. Neuroreport 1998; 9: 6-13.
24. Lowe EM, Anand P, Terenghi G, Williams-Chestnut RE, Sinicropi DV, Osborne JL. Increased nerve growth factor levels in the urinary bladder of women with idiopathic sensory urgency in interstitial cystitis. Br J Urology 1997; 79: 572-577.
25. Coward K, Plumpton C, Facer P, Birch R, Carlstedt T, Tate S. et al. Immunolocalization of SNS/PN3 and NaN/SNS2 sodium channels in human pain states. Pain 2000; 85: 41-50.
26. Yiangou Y, Facer P, Birch R, Sangameswaran L, Eglen R, Anand P. P2X3 receptor in injured human sensory neurons. Neuroreport 2000; 11: 993-996.
27. Andersen OK, Felsby S, Nicalaisen L, Bjerring P, Jensen TS, Adrent-Neilsen L. The effect of ketamine on stimulation of primary and secondary hyperalgesic areas induced by capsaicin-a double-blind placebo-controlled, human experimental study. Pain 1996; 66: 51-62.