Biomonitoring Equivalents (BE) dossier for trihalomethanes

Regulatory Toxicology and Pharmacology

Volumn 51, Issue 3 SUPPL., 2008, Pages

  Aylward, Lesa L ^a   LaKind, Judy S ^b   Hays, Sean M ^a  

^a LLP   (United States)

^b LaKind Associates LLC   (United States)

Author keywords

BE; Biomarkers; Biomonitoring equivalents; Bromodichloromethane; Bromoform; Chloroform; Dibromochloromethane; Drinking water disinfection byproducts; Risk assessment; THMs; Trihalomethanes

Indexed keywords

BIOLOGICAL MARKER; BROMODICHLOROMETHANE; BROMOFORM; CHLOROFORM; DIBROMOCHLOROMETHANE; DRINKING WATER; TRIHALOMETHANE;

ARTICLE; BLOOD LEVEL; CANCER RISK; CARCINOGENICITY; CYTOTOXICITY; DISINFECTION; ENVIRONMENTAL PROTECTION; EXPERIMENTAL DOG; EXPERIMENTAL MODEL; EXPERIMENTAL RAT; FATTY LIVER; HEALTH CARE ORGANIZATION; HUMAN; KIDNEY TUMOR; KINETICS; LARGE INTESTINE TUMOR; LIVER TUMOR; NEOPLASM; NONHUMAN; PHYSIOLOGY; POPULATION EXPOSURE; PRIORITY JOURNAL; RISK BENEFIT ANALYSIS; UNCERTAINTY; UNITED STATES;

ANIMALS; CARCINOGENS, ENVIRONMENTAL; DOGS; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; GUIDELINES AS TOPIC; HUMANS; MASS SCREENING; MODELS, BIOLOGICAL; NEOPLASMS; RATS; RISK ASSESSMENT; TRIHALOMETHANES; WATER POLLUTANTS, CHEMICAL;

CANIS FAMILIARIS; RATTUS NORVEGICUS;

EID: 47549107220     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2008.05.005     Document Type: Article

References (41)

1. Agency for Toxic Substances and Disease Registry (ATSDR), 1997. Toxicological Profile for Chloroform. Accessed on the web at: .
2. Agency for Toxic Substances and Disease Registry (ATSDR), 2005. Toxicological Profile for Bromoform and Dibromochloromethane. Accessed on the web at: .
3. Ashbolt N.J. Risk analysis of drinking water microbial contamination versus disinfection by-products (DBPs). Toxicology 198 (2004) 255-262
4. Ashley D.L., Blount B.C., Singer P.C., Depaz E., Wilkes C., Gordon S., Lyu C., and Masters J. Changes in blood trihalomethane concentrations resulting from differences in water quality and water use activities. Arch. Environ. Occup. Health 60 (2005) 7-15
5. Backer L.C., Ashley D.L., Bonin M.A., Cardinali F.L., Kieszak S.M., and Wooten J.V. Household exposures to drinking water disinfection by-products: whole blood trihalomethane levels. J. Expo. Anal. Environ. Epidemiol. 10 (2000) 321-326
6. Backer L.C., Lan Q., Blount B.C., Nuckols J.R., Branch R., Lyu C.W., Kieszak S.M., Brinkman M.C., Gordon S.M., Flanders W.D., Romkes M., and Cantor K.P. Exogenous and endogenous determinants of blood trihalomethane levels after showering. Environ. Health Perspect. 116 (2008) 57-63
7. Bonin M.A., Silva L.K., Smith M.M., Ashley D.A., and Blount B.C. Measurement of trihalomethanes and methyl tert-butyl ether in whole blood using gas chromatography with high-resolution mass spectrometry. J. Anal. Toxicol. 29 (2005) 81-89
8. Bull R.J., Birnbaum L.S., Cantor K.P., Rose J.B., Butterworth B.E., Pegram R., and Tuomisto J. Water chlorination: essential process or cancer hazard?. Fundam. Appl. Toxicol. 28 (1995) 155-166
9. Corley R.A., Mendrala A.L., Smith F.A., Staats D.A., Gargas M.L., Conolly R.B., Andersen M.E., and Reitz R.H. Development of a physiologically based pharmacokinetic model for chloroform. Toxicol. Appl. Pharmacol. 103 (1990) 512-527
10. Dodds L., King W., Allen A.C., Armson B.A., Fell D.B., and Nimrod C. Trihalomethanes in public water supplies and risk of stillbirth. Epidemiology 15 (2004) 179-186
11. Gargas M.L., Burgess R.J., Voisard D.E., Cason G.H., and Andersen M.E. Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues. Toxicol. Appl. Pharmacol. 98 (1989) 87-99
12. Haddad S., Tardif G.C., and Tardif R. Development of physiologically based toxicokinetic models for improving the human indoor exposure assessment to water contaminants: trichloroethylene and trihalomethanes. J. Toxicol. Environ. Health A. 69 (2006) 2095-2136
13. Havelaar A.H., De Hollander A.E., Teunis P.F., Evers E.G., Van Kranen J., Versteegh J.F., Van Koten J.E., and Slob W. Balancing the risks and benefits of drinking water disinfection: disability adjusted life-years on the scale. Environ. Health Perspect. 108 (2000) 15-21
14. Hays S.M., Becker R.A., Leung H.W., Aylward L.L., and Pyatt D.W. Biomonitoring equivalents: a screening approach for interpreting biomonitoring results from a public health risk perspective. Reg. Toxicol. Pharmacol. 47 (2007) 6-109
15. Hays S.M., Aylward L.L., LaKind J.S., Bartels M.J., Barton H.A., Boogaard P.J., Brunk C., DiZio S., Dourson M., Goldstein D.A., Lipscomb J., Kilpatrick M.E., Krewski D., Krishnan K., Nordberg M., Okino M., Tan Y.-M., Viau C., and Yager J.W. Guidelines for the derivation of biomonitoring equivalents: Report from the Biomonitoring Equivalents Expert Workshop. Reg. Toxicol. Pharmacol. 51 (2008) S4-S15
16. Heywood R., Sortwell R.J., Noel P.R.B., Street A.E., Prentice D.E., Roe F.J.C., Wadsworth P.F., Worden A.N., and Van Abbe N.J. Safety evaluation of toothpaste containing chloroform. III. Long-term study in beagle dogs. J. Environ. Pathol. Toxicol. 2 (1979) 835-851
17. King W.D., Marrett L.D., and Woolcott C.G. Case-control study of colon and rectal cancers and chlorination by-products in treated water. Cancer Epidemiol. Biomarkers Prev. 9 (2000) 813-818
18. LaKind J.S., Aylward L.L., Brunk C., DiZio S., Dourson M., Goldstein D.A., Kilpatrick M.E., Krewski D., Bartels M.J., Barton H.A., Boogaard P.J., Lipscomb J., Krishnan K., Nordberg M., Okino M., Tan Y.-M., Viau C., Yager J.W., and Hays S.M. Guidelines for the communication of Biomonitoring Equivalents: Report from the Biomonitoring Equivalents expert Workshop. Reg. Toxicol. Pharmacol. 51 (2008) S16-S26
19. Leavens T.L., Blount B.C., Demarini D.M., Madden M.C., Valentine J.L., Case M.W., Silva L.K., Warren S.H., Hanley N.M., and Pegram R.A. Disposition of bromodichloromethane in humans following oral and dermal exposure. Toxicol. Sci. 2007 99 (2007) 432-445
20. Lilly P.D., Andersen M.E., Ross T.M., and Pegram R.A. Physiologically based estimation of in vivo rates of bromodichloromethane metabolism. Toxicology 124 (1997) 141-152
21. Lilly P.D., Andersen M.E., Ross T.M., and Pegram R.A. A physiologically based pharmacokinetic description of the oral uptake, tissue dosimetry, and rates of metabolism of bromodichloromethane in the male rat. Toxicol. Appl. Pharmacol. 150 (1998) 205-217
22. Luciene da Silva M., Charest-Tardif G., Krishnan K., and Tardif R. Influence of oral administration of a quaternary mixture of trihalomethanes on their blood kinetics in the rat. Toxicol. Lett. 106 (1999) 49-57
23. Mahle D.A., Gearhart J.M., Grigsby C.C., Mattie D.R., Barton H.A., Lipscomb J.C., and Cook R.S. Age-dependent partition coefficients for a mixture of volatile organic solvents in Sprague-Dawley rats and humans. J. Toxicol. Environ. Health A 70 (2007) 1745-1751
24. Meek M., Beauchamp R., Long G., Moir D., Turner L., and Waker M. Chloroform: exposure estimation, hazard characterization, and exposure-response analysis. J. Toxicol. Environ. Health B 5 (2002) 283-334
25. Nieuwenhuijsen M.J., Toledano M.B., Eaton N.E., Fawell J., and Elliott P. Chlorination disinfection byproducts in water and their association with adverse reproductive outcomes: a review. Occup. Environ. Med. 57 (2000) 73-85
26. NRC (National Research Council), 2006. Human Biomonitoring for Environmental Chemicals. Committee on Human Biomonitoring for Environmental Toxicants, National Research Council. National Academies Press.
27. NTP (National Toxicology Program), 2006. NTP Toxicology and carcinogenesis studies of bromodichloromethane (CAS No. 75-27-4) in male F344/N rats and female B6C3F1 mice (Drinking Water Studies). Natl. Toxicol. Program Tech. Rep. Ser. 532, 1-248.
28. Nong A., McCarver D.G., Hines R.N., and Krishnan K. Modeling interchild differences in pharmacokinetics on the basis of subject-specific data on physiology and hepatic CYP2E1 levels: a case study with toluene. Toxicol. Appl. Pharmacol. 214 (2006) 78-87
29. Pelekis M., Gephart L.A., and Lerman S.E. Physiological-model-based derivation of the adult and child pharmacokinetic intraspecies uncertainty factors for volatile organic compounds. Regul. Toxicol. Pharmacol. 33 (2001) 12-20
30. Poobalasingham N., and Payne J. The uptake and elimination of chloroform in man. Br. J. Anaesth. 50 (1978) 325-329
31. Schoeny R., Haber L., and Dourson M. Data considerations for regulation of water contaminants. Toxicology 221 (2006) 217-224
32. Tan Y.M., Liao K.H., Conolly R.B., Blount B.C., Mason A.M., and Clewell H.J. Use of a physiologically based pharmacokinetic model to identify exposures consistent with human biomonitoring data for chloroform. J. Toxicol. Environ. Health A 69 (2006) 1727-1756
33. Tan Y.M., Liao K.H., and Clewell H.J. Reverse dosimetry: interpreting trihalomethanes biomonitoring data using physiologically based pharmacokinetic modeling. J. Expo. Sci. Environ. Epidemiol. 17 (2007) 591-603
34. Teuschler L.K., Rice G.E., Wilkes C.R., Lipscomb J.C., and Power F.W. A feasibility study of cumulative risk assessment methods for drinking water disinfection by-product mixtures. J. Toxicol. Environ. Health A 67 (2004) 755-777
35. Toledano M.B., Nieuwenhuijsen M.J., Best N., Whitaker H., Hambly P., de Hoogh C., Fawell J., Jarup L., and Elliott P. Relation of trihalomethane concentrations in public water supplies to stillbirth and birth weight in three water regions in England. Environ. Health Perspect. 113 (2005) 225-232
36. USEPA, 2005. Drinking Water Criteria Document for Brominated Trihalomethanes. Office of Water. EPA-822-R-05-11.
37. USEPA, 2006a. Stage 2 Disinfectants and Disinfection Byproduct Rule (Stage 2 DBP rule). Available from: .
38. USEPA, 2006b. Integrated Risk Information System. Chloroform. Last updated on Wednesday, March 8th, 2006. Available from: .
39. USEPA, 2006c. Exposures and Internal Doses of Trihalomethanes in Humans: Multi-Route Contributions from Drinking Water. National Center for Environmental Assessment, Office of Research and Development, Cincinnati, OH, EPA 600/R-06/087.
40. Villanueva C.M., Cantor K.P., Grimalt J.O., Malats N., Silverman D., Tardon A., Garcia-Closas R., Serra C., Carrato A., Castano-Vinyals G., Marcos R., Rothman N., Real F.X., Dosemeci M., and Kogevinas M. Bladder cancer and exposure to water disinfection by-products through ingestion, bathing, showering, and swimming in pools. Am. J. Epidemiol. 165 (2007) 148-156
41. Villanueva C.M., Gagniere B., Monfort C., Nieuwenhuijsen M.J., and Cordier S. Sources of variability in levels and exposure to trihalomethanes. Environ. Res. 103 (2007) 211-220