A physiologically based pharmacokinetic description of the oral uptake, tissue dosimetry, and rates of metabolism of bromodichloromethane in the male rat

Toxicology and Applied Pharmacology

Volumn 150, Issue 2, 1998, Pages 205-217

  Lilly, Patrick D ^a,b   Andersen, Melvin E ^b   Ross, Tracey M ^b   Pegram, Rex A ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROMODICHLOROMETHANE; CORN OIL; DRUG METABOLITE; EMULPHOR; EMULSIFYING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; BREATH ANALYSIS; CONTROLLED STUDY; DOSIMETRY; DRUG ABSORPTION; DRUG METABOLISM; DRUG TISSUE LEVEL; KIDNEY; LIVER; MALE; METABOLIC RATE; MODEL; NONHUMAN; ORAL DRUG ADMINISTRATION; PARTITION COEFFICIENT; PHARMACOKINETICS; RAT; RISK ASSESSMENT;

ANIMALIA; ZEA MAYS;

EID: 0032104187     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1998.8405     Document Type: Article

References (30)

1. Angelo M. J., Pritchard A. B. Simulations of methylene chloride pharmacokinetics using a physiological model. Regul. Toxicol. Pharmacol. 4:1984;329-339.
2. Cantor K. P., Hoover R., Mason T. J., McCabe J. L. Associations of cancer mortality with halomethanes in drinking water. J. Natl. Cancer Inst. 4:1978;979-985.
3. Chieco P., Molsen M. T., Reynolds E. S. Effect of administrative vehicle on oral 1,1-dichloroethylene toxicity. Toxicol. Appl. Pharmacol. 57:1978;146-155.
4. Condie L. W., Smallwood C. L., Laurie R. D. Comparative renal and hepatotoxicity of halomethanes: Bromodichloromethane, bromoform, chloroform, dibromochloromethane and methylene chloride. Drug Chem. Toxicol. 6:1983;563-578.
5. Corley R. A., Mendrala A. L., Smith F. A., Staats D. A., Gargas M. L., Conolly R. B., Andersen M. E., Reitz R. H. Development of a physiologically based pharmacokinetic model for chloroform. Toxicol. Appl. Pharmacol. 103:1990;512-527.
6. Dunnick J. K., Eustis S. L., Lilja H. S. Bromodichloromethane, a trihalomethane that produces neoplasms in rodents. Cancer Res. 47:1987;5189-5193.
7. Fisher J. W., Whittaker T. A., Taylor D. H., Clewell H. J. III, Andersen M. E. Physiologically based pharmacokinetic modeling of pregnant rat: A multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid. Toxicol. Appl. Pharmacol. 99:1989;395-414.
8. Gallo J. M., Cheung L. L., Kim H. J., Bruckner J. V., Gillespie W. R. A physiological and system analysis hybrid pharmacokinetic model to characterize carbon tetrachloride blood concentrations following administration in different dosing vehicles. J. Pharmacokinet. Biopharm. 21:1993;551-574.
9. Gargas M. L., Andersen M. E. Metabolism of inhaled brominated hydrocarbons: Validation of gas uptake results by determination of a stable metabolite. Toxicol. Appl. Pharmacol. 66:1982;55-68.
10. Gargas M. L., Andersen M. E. Determining kinetic constants of chlorinated ethane metabolism in the rat from rates of exhalation. Toxicol. Appl. Pharmacol. 99:1989;344-353.
11. Gargas M. L., Clewell H. J. III, Andersen M. E. Metabolism of inhaled dihalomethanesin vivo: Toxicol. Appl. Pharmacol. 82:1986;211-223.
12. Jorgenson T. A., Meierhenry E. F., Rushbrook C. J., Bull R. J., Robinson M. Carcinogenicity of chloroform in drinking water to male Osborne-Mendel rats and female B6C3F1 mice. Fundam. Appl. Toxicol. 57:1985;34-49.
13. Kim H. J., Bruckner J. V., Dallas C. E., Gallo J. M. Effect of dosing vehicles on the pharmacokinetics of orally administered carbon tetrachloride in rats. Toxicol. Appl. Pharmacol. 102:1990a;50-60.
14. Kim H. J., Odend'hal S., Bruckner J. V. Effect of oral dosing vehicles on the acute hepatotoxicity of carbon tetrachloride in rats. Toxicol. Appl. Pharmacol. 102:1990b;34-49.
15. King W. D., Marrett L. D. Case-control study of bladder cancer and chlorination by-products in treated water (Ontario, Canada). Cancer Causes Control. 7:1996;596-604.
16. Krasner S. W., McGuire M. J., Jacangelo J. G., Patania N. L., Reagan K. M., Aieta E. M. The occurrence of disinfection by-products in U.S. drinking water. J. Am. Water Works Assoc. 81:1989;41-53.
17. Larson J. L., Wolf D. C., Butterworth B. E. Induced cytotoxicity and cell proliferation in the hepatocarcinogenicity of chloroform in female B6C3F1 mice: Comparison of administration by gavage in corn oil vs ad libitum in drinking water. Fundam. Appl. Toxicol. 22:1994;90-102.
18. Lilly P. D., Andersen M. E., Ross T. M., Pegram R. A. Physiologically based estimation of in vivo rates of bromodichloromethane metabolism. Toxicology. 124:1997;141-152.
19. Lilly P. D., Simmons J. E., Pegram R. A. Dose-dependent vehicle differences in the acute toxicity of bromodichloromethane. Fundam. Appl. Toxicol. 23:1994;132-140.
20. Morris R. D., Audet A. M., Angelillo I. F., Chalmers T. C., Mosteller F. Chlorination, chlorination by-products, and cancer: A meta-analysis. Am. J. Public Health. 82:1992;955-963.
21. National Cancer Institute (NCI), 976, Carcinogenesis Bioassay of Chloroform.
22. National Institutes of Health, 1985, Guide for the Use and Care of Laboratory Animals, U.S. Department of Health and Human Services, Public Health Service.
23. National Toxicology Program (NTP), 1987, Toxicology and Carcinogenesis Studies of Bromodichloromethane in F344/N Rats and B6C3F1 Mice.
24. Pegram R. A., Andersen M. E., Warren S. H., Ross T. M., Claxton L. D. GlutathioneSSalmonella typhimurium. Toxicol. Appl. Pharmacol. 144:1997;183-188.
25. Ramsey J. C., Andersen M. E. A physiologically based description of the inhalation pharmacokinetics of styrene monomer in rats and humans. Toxicol. Appl. Pharmacol. 73:1984;159-175.
26. Semino G., Lilly P. D., Andersen M. E. A pharmacokinetic model describing pulsatile uptake of orally-administered carbon tetrachloride. Toxicology. 117:1997;25-33.
27. Staats D. A., Fisher J. W., Connolly R. B. Gastrointestinal absorption of xenobiotics in physiologically based pharmacokinetic models: A two-compartment description. Drug Metab. Dispos. 19:1991;144-148.
28. Thornton-Manning J., Gao P., Lilly P. D., Pegram R. A. Acute bromodichloromethane toxicity in rats pretreated with cytochrome P450 inducers and inhibitors. Toxicologist. 13:1993;361.
29. Tomasi A., Albano E., Biasi F., Slater T. F., Vannini V., Dianzani M. U. Activation of chloroform and related trihalomethanes to free radical intermediates in isolated hepatocytes and in the rat in vivo as detected by the ESR-spin trapping technique. Chem.-Biol. Interact. 55:1985;303-316.
30. United States Environmental Protection Agency (U.S. EPA), 1990, Final Report for Disinfection By-Products in United States Drinking Waters.