Treatment of severe malnutrition with 2-day intramuscular ceftriaxone vs 5-day amoxicillin

Annals of Tropical Paediatrics

Volumn 28, Issue 1, 2008, Pages 13-22

  Dubray, Christine ^a   Ibrahim, Salah A ^b   Abdelmutalib, Mohamed ^b   Guerin, Philippe J ^a   Dantoine, François ^a   Belanger, François ^a   Legros, Dominique ^c   Pinoges, Loretxu ^a   Brown, Vincent ^a  

^a EPICENTRE   (France)

^b UNIVERSITY OF KHARTOUM   (Sudan)

^c WORLD HEALTH ORGANIZATION   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; CEFTRIAXONE; COTRIMOXAZOLE; DEXAMETHASONE; FOLIC ACID; IRON; MEBENDAZOLE; RETINOL; ANTIINFECTIVE AGENT;

ARM CIRCUMFERENCE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEHYDRATION; DIARRHEA; DISEASE SEVERITY; DRUG EFFICACY; DRUG HYPERSENSITIVITY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FACE EDEMA; FATALITY; FEMALE; FOLLOW UP; HUMAN; INFANT; INJECTION SITE INFECTION; INJECTION SITE PAIN; MAJOR CLINICAL STUDY; MALE; MALNUTRITION; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; REHYDRATION; REMISSION; SUDAN; VITAMIN SUPPLEMENTATION; VOMITING; WEIGHT GAIN; AGE; ANTHROPOMETRY; COMPARATIVE STUDY; DRUG ADMINISTRATION; INTRAMUSCULAR DRUG ADMINISTRATION; LENGTH OF STAY; NUTRITIONAL DISORDER; OPPORTUNISTIC INFECTION; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; STATISTICS; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; AGE FACTORS; AMOXICILLIN; ANTHROPOMETRY; ANTI-BACTERIAL AGENTS; CEFTRIAXONE; CHILD, PRESCHOOL; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; INFANT; INFANT NUTRITION DISORDERS; INJECTIONS, INTRAMUSCULAR; LENGTH OF STAY; MALE; OPPORTUNISTIC INFECTIONS; TREATMENT OUTCOME; WEIGHT GAIN;

EID: 47549106529     PISSN: 02724936     EISSN: None     Source Type: Journal    
DOI: 10.1179/146532808X270635     Document Type: Article

References (17)

1. Young H, Borrel A, Holland D, Salama P. Public nutrition in complex emergencies. Lancet 2004; 364:1899-909.
2. Toole MJ, Nieburg P, Waldman RJ. The association between inadequate rations, undernutrition prevalence, and mortality in refugee camps: Case studies of refugee populations in eastern Thailand, 1979-1980, and eastern Sudan, 1984-1985. J Trop Pediatr 1988; 34:218-24
3. Bhan MK, Bhandari N, Bahl R. Management of the severely malnourished child: Perspective from developing countries. Br Med J 2003; 326:146-51.
4. Ashworth A, Chopra M, McCoy D, et al. WHO guidelines for management of severe malnutrition in rural South African hospitals: effect on case fatality and the influence of operational factors. Lancet 2004; 363:1110-15.
5. Deen JL, Funk M, Guevara VC, et al. Implementation of WHO guidelines on management of severe malnutrition in hospitals in Africa. Bull WHO 2003; 81:237-43.
6. Wilkinson D, Scrace M, Boyd N. Reduction in in-hospital mortality of children with malnutrition. J Trop Pediatr 1996; 42:114-15.
7. Phillips I, Wharton B. Acute bacterial infection in kwashiorkor and marasmus. Br Med J 968; 1:407-9.
8. World Health Organization. Management of Severe Acute Malnutrition: A Manual for Physicians and Other Senior Health Workers. Geneva: WHO, 1999.
9. Krishnaswamy K. Drug metabolism and pharmacokinetics in malnourished children. Clin Pharmacokinet 1989; 17 (suppl 1: 68-88
10. Noorani N, Macharia WM, Oyatsi D, Revathi G. Bacterial isolates in severely malnourished children at Kenyatta National Hospital, Nairobi. East Afr Med J 2005; 82:343-8.
11. Varsano I, Volovitz B, Horev Z, et al. Intramuscular ceftriaxone compared with oral amoxicillin-clavulanate for treatment of acute otitis media in children. Eur J Pediatr 1997; 156:858-63.
12. Baskin MN, O'Rourke EJ, Fleisher GR. Outpatient treatment of febrile infants 28 to 89 days of age with intramuscular administration of ceftriaxone. J Pediatr 1992; 120:22-7.
13. Laplanche A, Com-Nougué C, Flamant R. Méthodes statistiques appliquées à la recherche clinique. Analyse d'un essai. Paris, France: Médecine Science Flammarion, 2001; 65-74.
14. Christie CD, Heikens GT, McFarlane DE. Nosocomial and community-acquired infections in malnourished children. J Trop Med Hyg 1988; 91:173-80.
15. Collins S, Sadler K. Outpatient care for severely malnourished children in emergency relief programmes: A retrospective cohort study. Lancet 2002; 360:1824-30.
16. Collins S. Changing the way we address severe malnutrition during famine. Lancet 2001; 358:498-501.
17. Gaboulaud V, Dan-Bouzoua N, Brasher C, Gergonne B, Brown V. Could nutritional rehabilitation at home complement or replace centre based therapeutic feeding programs for severe malnutrition? Trop Pediatr 2007; 53:49-51.