Dihydrotestosterone inhibits murine hair growth via the androgen receptor

British Journal of Dermatology

Volumn 159, Issue 2, 2008, Pages 300-305

  Naito, A ^a   Sato, T ^b   Matsumoto, T ^b   Takeyama, K ^b   Yoshino, T ^a   Kato, S ^b   Ohdera, M ^a  

^a LION CORPORATION   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Androgen receptor knockout mouse; Androgenetic alopecia; Hair cycle

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CUTANEOUS PARAMETERS; GROWTH INHIBITION; HAIR GROWTH; HAIR LENGTH; HAIR THICKNESS; HISTOLOGY; MALE; MORPHOMETRICS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; DIHYDROTESTOSTERONE; HAIR; HAIR REMOVAL; MALE; MICE; MICE, KNOCKOUT; RECEPTORS, ANDROGEN;

EID: 47549105508     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2008.08671.x     Document Type: Article

References (40)

1. Stenn KS, Paus R. Controls of hair follicle cycling. Physiol Rev 2001 81 : 449 94.
2. Chase HB. Growth of the hair. Physiol Rev 1954 34 : 113 26.
3. Hamilton JB. Patterned loss of hair in man; types and incidence. Ann NY Acad Sci 1951 53 : 708 28.
4. Hamilton JB. Male hormone stimulation is prerequisite and an incitant in common baldness. Am J Anat 1942 71 : 451 80.
5. Hiort JB, Zitzmann M. Androgen receptor: pathophysiology. In : Testosterone: Action, Deficiency and Substitution (Nieschlag E, Behre HM, eds). Cambridge : Cambridge University Press, 2004 93 124.
6. Bergfeld WF. Androgenetic alopecia: an autosomal dominant disorder. Am J Med 1995 98 : 95 8.
7. Davis BK. Quantitative morphological studies upon the influence of the endocrine system on the growth of hair by white mice. Acta Endocrinol Suppl 1963 85 : 102.
8. Ebling FJ, Johnson E. The action of hormones on spontaneous hair growth cycles in the rat. J Endocrinol 1964 29 : 193 201.
9. Ebling FJ, Hale PA. The control of the mammalian moult. Mem Soc Endocrinol 1970 16 : 215 37.
10. Duncan MJ, Goldman BD. Hormonal regulation of the annual pelage color cycle in the Djungarian hamster, Phodopus sungorus. I. Role of the gonads and the pituitary. J Exp Zool 1984 230 : 89 95.
11. Maurel D, Coutant C, Boissin J. Thyroid and gonadal regulation of hair growth during the seasonal molt in the male European badger, Meles meles L. Gen Comp Endocrinol 1987 65 : 317 27.
12. Johnson E. Qualitative studies of hair growth in the albino rat II. The effects of sex hormones. J Endocrinol 1958 16 : 351 9.
13. Mohn MP. The effects of different hormonal states on the growth of hair in rats. In : The Biology of Hair Growth (Montagna W, Ellis RA, eds). New York : Academic Press, 1958 336 99.
14. Kato S. Androgen receptor structure and function from knock-out mouse. Clin Pediatr Endocrinol 2002 11 : 1 7.
15. Sato T, Matsumoto T, Yamada T et al. Late onset of obesity in male androgen receptor-deficient (AR KO) mice. Biochem Biophys Res Commun 2003 300 : 167 71.
16. Kawano H, Sato T, Yamada T et al. Suppressive function of androgen receptor in bone resorption. Proc Natl Acad Sci USA 2003 100 : 9416 21.
17. Jean-Faucher C, Berger M, de Turckheim M et al. Developmental patterns of plasma and testicular testosterone in mice from birth to adulthood. Acta Endocrinol 1978 89 : 780 8.
18. Sato T, Matsumoto T, Kawano H et al. Brain masculinization requires androgen receptor function. Proc Natl Acad Sci USA 2004 101 : 1673 8.
19. Yeh S, Tsai MY, Xu Q et al. Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen function in selective tissues. Proc Natl Acad Sci USA 2002 99 : 13498 503.
20. Yokoyama D. Characteristics and problems of evaluation methods for hair growing effect. Fragrance J 1999 27 : 50 6.
21. Matsuda H, Yamazaki M, Naruto S et al. Anti-androgenic and hair growth promoting activities of lygodii spora (spore of Lygodium japonicum) I. Active constituents inhibiting testosterone 5α-reductase. Biol Pharm Bull 2002 25 : 622 6.
22. Müller-Röver S, Handjiski B, van der Veen C et al. A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J Invest Dermatol 2001 117 : 3 15.
23. Houssay AB, Higgins GM. Hormonal influences upon the rate of growth of hair in gonadectomized mice. Mayo Clin Proc 1949 24 : 597 604.
24. Price P, Wass JA, Griffin JE et al. High dose androgen therapy in male pseudohermaphroditism due to 5 alpha-reductase deficiency and disorders of the androgen receptor. J Clin Invest 1984 74 : 1496 508.
25. Simoncini T, Ganazzani AR. Non-genomic actions of sex steroid hormones. Eur J Endocrinol 2003 148 : 281 92.
26. Grillo ML, Jacobus AP, Scalco R et al. Testosterone rapidly stimulates insulin release from isolated pancreatic islets through a non-genomic dependent mechanism. Horm Metab Res 2005 37 : 662 5.
27. Leung SW, Teoh H, Keung W et al. Non-genomic vascular actions of female sex hormones: physiological implications and signaling pathways. Clin Exp Pharmacol Physiol 2007 34 : 822 6.
28. Hébert JM, Rosenquist T, Götz J et al. FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations. Cell 1994 78 : 1017 25.
29. Sundberg JP, Rourk MH, Boggess D et al. Angora mouse mutation: altered hair cycle, follicular dystrophy, phenotypic maintenance of skin grafts, and changes in keratin expression. Vet Pathol 1997 34 : 171 9.
30. van Scott EJ, Ekel TM. Geometric relationships between the matrix of the hair bulb and its dermal papilla in normal and alopecic scalp. J Invest Dermatol 1958 31 : 281 7.
31. Elliott K, Stephenson TJ, Messenger AG. Differences in hair follicle dermal papilla volume are due to extracellular matrix volume and cell number: implications for the control of hair follicle size and androgen responses. J Invest Dermatol 1999 113 : 873 7.
32. Ebling FJ, Hale PA, Randall VA. Hormones and hair growth. In : Biochemistry and Physiology of the Skin (Goldsmith LA, ed.). Oxford : Clarendon Press, 1991 660 90.
33. Hale PA, Ebling FJ. The effects of epilation and hormones on the activity of rat hair follicles. J Exp Zool 1975 191 : 49 62.
34. Oh H-S, Smart RC. An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation. Proc Natl Acad Sci USA 1996 93 : 12525 30.
35. Smart RC, Oh H-S, Chanda S, Robinette CL. Effect of 17-β-estradiol and ICI 182 780 on hair growth in various strains of mice. J Investig Dermatol Symp Proc 1999 4 : 285 9.
36. Chanda S, Robinette CL, Couse JF, Smart RC. 17β-estradiol and ICI-182780 regulate the hair follicle cycle in mice through an estrogen receptor-α pathway. Am J Physiol Endocrinol Metab 2000 278 : 202 10.
37. Ota Y, Saitoh Y, Suzuki S et al. Fibroblast growth factor 5 inhibits hair growth by blocking dermal papilla cell activation. Biochem Biophys Res Commun 2002 290 : 169 76.
38. Foitzik K, Lindner G, Müller-Röver S et al. Control of murine hair follicle regression (catagen) by TGF-β1 in vivo. FASEB J 2000 14 : 752 60.
39. Botchkarev VA, Botchkareva NV, Welker P et al. A new role for neurotrophins: involvement of brain-derived neurotrophic factor and neurotrophin-4 in hair cycle control. FASEB J 1999 13 : 395 410.
40. Inui S, Fukuzato Y, Nakajima T et al. Androgen-inducible TGF-β1 from balding dermal papilla cells inhibits epithelial cell growth: a clue to understanding paradoxical effects of androgen on human hair growth. FASEB J 2002 16 : 1967 9.