Fibroblast growth factor 5 inhibits hair growth by blocking dermal papilla cell activation

Biochemical and Biophysical Research Communications

Volumn 290, Issue 1, 2002, Pages 169-176

  Ota, Yutaka ^a   Saitoh, Yuko ^a   Suzuki, Satoshi ^a   Ozawa, Kazuo ^b   Kawano, Mitsuko ^b   Imamura, Toru ^b  

^a POLA CHEMICAL INDUSTRIES INC   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

Conditioned medium; Dermal papilla cell; FGF receptor; FGF 1, FGF 2; Outer root sheath cell

Indexed keywords

FIBROBLAST GROWTH FACTOR 5; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 4;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL CULTURE; CELL ISOLATION; CELL PROLIFERATION; CELL TYPE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFECT; GROWTH INHIBITION; HAIR FOLLICLE; HAIR GROWTH; HAIR LOSS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SKIN CELL; VIBRISSA;

EID: 0036289731     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.6140     Document Type: Article

References (54)

1. Fibroblast growth factor influences the development and cycling of murine hair follicles
2. Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice
3. Human endothelial cell growth factor: Cloning, nucleotide sequence, and chromosome location
4. Human basic fibroblast growth factor: Nucleotide sequence and genomic organization
5. Sequence, topography and protein coding potential of mouse int-2: A putative oncogene activated by mouse mammary tumour virus
6. Processing, secretion, and biological properties of a novel growth factor of the fibroblast growth factor family with oncogenic potential
7. The heparin-binding (fibroblast) growth factor family of proteins
8. Characterization of the HST-related FGF 6 gene, a new member of the fibroblast growth factor gene family
9. Purification and characterization of a newly identified growth factor specifc for epithelial cells
10. The fibroblast growth factor family
11. Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells
12. Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property
13. Fibroblast growth factors: Activities and significance of non-neurotropin neurotropic growth factors
14. The ins and outs of fibroblast growth factors
15. Human androgen-induced growth factor in prostate and breast cancer cells: Its molecular cloning and growth properties
16. Structure and expression of the rat mRNA encoding a novel member of the fibroblast growth factor family
17. Chromosomal mapping of two novel human FGF gene, FGF-11 and FGF-12
18. Murine FGF-12 and FGF-13: Expression in embryonic nervous system, connective tissue and heart
19. Structure and expression of a novel isoform of mouse FGF homologous factor (FHF)-4
20. A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx 1
21. Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family
22. Recombinant rat fibroblast growth factor-16: Structure and biological activity
23. Structure and expression of a novel fibroblast growth factor, FGF-17, preferentially expressed in the embryonic brain
24. Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18
25. FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation
26. Human fibroblast growth factor-18 stimulates fibroblast cell proliferation and is mapped to chromosome 14p11
27. Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain
28. Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22
29. Identification of a novel FGF, FGF-21, preferentially expressed in liver
30. Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle
31. Identification of novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain
32. Human oncogenes detected by a defined medium culture assay
33. The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors
34. FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations
35. An alternatively-spliced FGF-5 mRNA is abundant in brain and translates into a partial agonist/antagonist for FGF-5 neurotrophic activity
36. The rat FGF-5 mRNA variant generated by alternative splicing encodes a novel truncated form of FGF-5
37. Dualmode regulation of hair growth cycle by two Fgf-5 gene products
38. Soluble factors from human hair papilla cells and dermal fibroblasts dramatically increase the clonal growth of outer root sheath cells
39. Hepatocyte growth factor/scatter factor expressed in follicular papilla cells stimulates human hair growth in vitro
40. Androgen induction of follicular epithelial cell growth is mediated via insulin-like growth factor-I from dermal papilla cells
41. Fibroblast growth factor signaling in the hair growth cycle: Expression of the fibroblast growth factor receptor and ligand gene in the murine hair follicle
42. Localization of rat FGF-5 protein in skin macrophage-like cells and FGF-5S protein in hair follicle: Possible involvement of two Fgf-5 gene products in hair growth cycle regulation
43. Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5
44. Use of T7 RNA polymerase to direct expression of cloned genes
45. The culture of dermal papilla cells from human hair follicles
46. Segregation of keratinocyte colony-forming cells in the bulge of the rat vibrissa
47. Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3
48. Effect of heparin on the binding affinity of acidic FGF for the cloned human FGF receptors, flg and bek
49. Receptor specificity of the fibroblast growth factor family
50. Effect of epidermal growth factor, fibroblast growth factor, minoxidil and hydrocortisone on growth kinetics in human hair bulb papilla cells and root sheath fibroblasts cultured in vitro
51. Patterns of expression of murine Vgr-1 and BMP-2a RNA suggested that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development
52. Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenic protein-2A (BMP-2A)
53. Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia
54. Analysis of apoptotic cell death in human hair follicles in vivo and in vitro