Royal jelly peptides inhibit lipid peroxidation in vitro and in vivo

Journal of Nutritional Science and Vitaminology

Volumn 54, Issue 3, 2008, Pages 191-195

  Guo, Hang ^a   Ekusa, Ai ^a   Iwai, Koji ^a   Yonekura, Masami ^b   Takahata, Yoshihisa ^a   Morimatsu, Fumiki ^a  

^a NIPPON MEAT PACKERS INC   (Japan)

^b IBARAKI UNIVERSITY   (Japan)

Author keywords

Antioxidative activity; Lipid peroxidation; Royal jelly peptides

Indexed keywords

CHOLESTEROL; HYDROXYL RADICAL; LIPID; LOW DENSITY LIPOPROTEIN; NITRILOTRIACETATE IRON; PROTEIN HYDROLYSATE; PROTEINASE; ROYAL JELLY; WATER;

ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROL GROUP; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INHIBITION; IN VITRO STUDY; IN VIVO STUDY; LIPID BLOOD LEVEL; LIPID PEROXIDATION; LIPOPROTEIN BLOOD LEVEL; MALE; NONHUMAN; PROTEIN ISOLATION; RAT; STATISTICAL SIGNIFICANCE; TREATMENT DURATION; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; CARCINOGENS; CHOLESTEROL; FATTY ACIDS; FERRIC COMPOUNDS; FREE RADICAL SCAVENGERS; HYDROLYSIS; LIPID PEROXIDATION; LIPIDS; MALE; NITRILOTRIACETIC ACID; OXIDATIVE STRESS; PEPTIDES; RATS; RATS, WISTAR; TIME FACTORS;

RATTUS; RATTUS NORVEGICUS;

EID: 47549096029     PISSN: 03014800     EISSN: 18817742     Source Type: Journal    
DOI: 10.3177/jnsv.54.191     Document Type: Article

References (41)

1. Del Maestro RE 1980. An approach to free radicals in medicine and biology. Acta Physiol Scand Suppl 492: 153-168.
2. Radi R. 1993. Biological antioxidant defenses. Toxicol Ind Health 9: 53-62.
3. Krinsky NI. 1992. Mechanism of action of biological antioxidants. Proc Soc Exp Biol Med 200: 248-254.
4. Cohen G. 1985. The Fenton reaction. In: Handbook of Methods for Oxygen Radical Research (Greenwald RA, ed), p 55-64. CRC Press, Boca Raton, Florida.
5. Hirose N, Doi F, Ueki T, Akazawa K, Chijiiwa K, Sugano M, Akimoto K, Shimizu S, Yamada H. 1992. Suppressive effect of sesamin against 7,12-dimethylbenz[a]-an-thracene induced rat mammary carcinogenesis. Anticancer Res 12: 1259-1265.
6. Anthony MS, Clarkson TB, Williams JK. 1998. Effects of soy isoflavones on atherosclerosis: potential mechanisms. Am J Clin Nutr 68: 1390S-1393S.
7. FitzGerald RJ, Murray BA, Walsh DJ. 2004. Hypotensive peptides from milk proteins. J Nutr 134: 980S-988S.
8. Fujita H, Yokoyama K, Yoshikawa M. 2000. Classification and antihypertensive activity of angiotensin I-converting enzyme inhibitory peptides derived from food proteins. J Food Sci 65: 564-569.
9. Lee JS. 2006. Effects of soy protein and genistein on blood glucose, antioxidant enzyme activities, and lipid profile in streptozotocin-induced diabetic rats. Life Sci79: 1578-1584.
10. Tolnai S, Morgan JF. 1962. Studies on the in vitro antitumour activity of fatty acids v. unsaturated acids. Can J Biochem Physiol 40: 869-875.
11. Tokunaga KH, Yoshida C, Suzuki KM, Maruyama H, Futamura Y, Araki Y, Mishima S. 2004. Antihypertensive effect of peptides from royal jelly in spontaneously hypertensive rats. Biol Pharm Bull 27: 189-192.
12. Kohno K, Okamoto I, Sano 0, Arai N, Iwaki K, Ikeda M, Kurimoto M. 2004. Royal jelly inhibits the production of proinflammatory cytokines by activated macrophages. Biosci Biotech Biochem 68: 138-145.
13. Okamoto I, Taniguchi Y, Kunikata T, Kohno K, Iwaki K, Ikeda M, Kurimoto M. 2003. Major royal jelly protein 3 modulates immune responses in vitro and in vivo. Life Sci 73: 2029-2045.
14. Kimura M, Kimura Y, Tsumura K, Okihara K, Sugimoto H, Yamada H, Yonekura M. 2003. 350-kDa royal jelly glycoprotein (apisin), which stimulates proliferation of human monocytes, bears the β1-3galactosylated N-glycan: analysis of the N-glycosylation site. Biosci Biotech Biochem 67: 2055-2058.
15. Nagai T, Inoue R. 2004. Preparation and the functional properties of water extract and alkaline extract of royal jelly. Food Chem 84: 181-186.
16. Guo H, Kouzuma Y, Yonekura M. 2005. Isolation and properties of antioxidative peptides from water-soluble royal jelly protein hydrolyzate. Food Sci Technol Res 11: 222-230.
17. Ebina Y, Okada S, Hamazaki S, Ogino F, Li JL, Midorikawa O. 1986. Nephrotoxicity and renal cell carcinoma after use of iron- and aluminum-nitrilotriacetate complexes in rats. J Natl Cancer Inst 76: 107-113.
18. Ueno S, Kashimoto T, Susa N, Shiho K, Seki T, Ito N, Takeda-Homma S, Nishimura Y, Sugiyama M. 2007. Estimation of hydroxyl radical generation by salicylate hydroxylation method in kidney of mice exposed to ferric nitrilotriacetate and potassium bromate. Free Radic Res 41: 1246-1252.
19. Toyokuni S. 1996. Iron-induced carcinogenesis: the role of redox regulation. Free Radic Biol Med 20: 553-566.
20. Toyokuni S, Uchida K, Okamoto K, Hattori-Nakakuki Y, Hiai H, Stadtman ER. 1994. Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate. Proc Natl Acad Sci USA 91: 2616-2620.
21. Umemura T, Sai K, Takagi A, Hasegawa R, Kurokawa Y. 1990. Formation of 8-hydroxydeoxyguanosine (8-OH-dG) in rat kidney DNA after intraperitoneal administration of ferric nitrilotriacetate (Fe-NTA). Carcinogenesis 11: 345-347.
22. Okada S, Midorikawa O. 1982. Induction of rat renal adenocarcinoma by Ferric nitrilotriacetate (Fe-NTA). Jpn Arch Internal Med 29: 485-491 (in Japanese).
23. Tanaka T, Nishiyama Y, Okada K, Hirota K, Matsui M, Yodoi J, Hiai H, Toyokuni S. 1997. Induction and nuclear translocation of thioredoxin by oxidative damage in the mouse kidney: independence of tubular necrosis and sulfhydryl depletion. Lab Invest 77: 145-155.
24. Iqbal M, Giri U, Athar M. 1995. Ferric nitrilotriacetate (Fe-NTA) is a potent hepatic tumor promoter and acts through the generation of oxidative stress. Biochem Biophys Res Commun 212: 557-563.
25. Qi W, Reiter RJ, Tan DX, Manchester LC, Kim SJ, Garcia JJ. 1999. Inhibitory effects of melatonin on ferric nitrilotriacetate-induced lipid peroxidation and oxidative DNA damage in the rat kidney. Toxicology 139: 81-91.
26. Iqbal M, Rezazadeh H, Ansar S, Athar M. 1998. Alpha-Tocopherol (vitamin-E) ameliorates ferric nitrilotriacetate (Fe-NTA)-dependent renal proliferative response and toxicity: diminution of oxidative stress. Hum Exp Toxicol 17: 163-171.
27. Umemura T, Hasegawa R, Sai-Kato K, Nishikawa A, Furukawa F, Toyokuni S, Uchida K, Inoue T, Kurokawa Y. 1996. Prevention by 2-mercaptoethane sulfonate and N-acetylcysteine of renal oxidative damage in rats treated with ferric nitrilotriacetate. Jpn J Cancer Res 87: 882-886 (in Japanese).
28. Khan N, Sharma S, Sultana S. 2004. Amelioration of ferric nitrilotriacetate (Fe-NTA) induced renal oxidative stress and tumor promotion response by coumarin (1,2-benzopyrone) in Wistar rats. Cancer Lett 210: 17-26.
29. Gao RM, Yuan ZB, Ding HB, Liu FM. 1998. Use of deoxyribose as a probe for the determination of rate constants for reactions of hydroxyl radicals on mercury electrodes. Bioelectrochem Bioener 45: 123-126.
30. Suda I, Furuta S, Nishiba Y. 1994. Fluorometric determination of a l,3-diethyl-2-thiobarbituric acid-malond-ialdehyde adduct as an index of lipid peroxidation in plant materials. Biosci Biotech Biochem 58: 14-17.
31. Kawabata T, Awai M, Kohno M. 1986. Generation of active oxygen species by iron nitrilotriacetate (Fe-NTA). Acta Med Okayama 40: 163-173.
32. Ohishi N, Ohkawa H, Miike A, Tatano T, Yagi K. 19 8 5. A new assay method for lipid peroxides using a methylene blue derivative. Biochem Int 10: 205-211.
33. Liu F, Ng TB. 2000. Antioxidative and free radical scavenging activities of selected medicinal herbs. Life Sci 66: 725-735.
34. Halliwell B. 1994. Free radicals and antioxidants: a personal view. Nutr Rev 52: 253-265.
35. Rosa A, Deiana M, Corona G, Atzeri A, Incani A, Dessi MA. 2005. Cholesterol as target of Fe-NTA-induced lipid peroxidation in rat tissues. Toxicol Lett 157: 1-8.
36. Chen JR, Okada T, Muramoto K, Suetsuna K, Yang SC. 2003. Identification of angiotensin I converting enzyme inhibitory peptides derived from the peptic digest of soybean protein. J Food Biochem 26: 543-554.
37. Suetsuna K, Ukeda H, Ochi H. 2000. Isolation and characterization of free radical scavenging activities peptides derived from casein. J Nutr Biochem 11: 128-131.
38. Tsuge N, Eikawa Y, Nomura Y, Yamamoto M, Sugisawa K. 1991. Antioxidative activity of peptides prepared by enzymatic hydrolysis of egg white albumin. Nippon Nogeikagaku Kaishi 65: 1635-1641.
39. Nagasawa T, Yonekura T, Nishizawa N, Kitts DD. 2001. In vitro and in vivo inhibition of muscle lipid and protein oxidation by carnosine. Mol Cell Biochem 225: 29-34.
40. Takenaka T, Takenaka Y. 2004. Effects of royal jelly protein hydrolysate on lipid and hydroperoxide level of plasma and liver in high cholesterol fed rats. Jpn Food Preser Sci 30: 167-171 (in Japanese).
41. Uno K, Kishi J, Kobayashi Y, Kishida A. 1995. Effect of the oral administration of protease-treated royal jelly on routine blood tests, immune responses and subjective symptoms. Clinical Report 29: 93 7-947 (in Japanese).