Immunologic features of HIV-1-infected women on HAART at delivery

Cytometry Part B - Clinical Cytometry

Volumn 74, Issue 4, 2008, Pages 236-243

  Ono, Erika ^a   Dos Santos, Amélia M N ^a   Machado, Daisy M ^a   Succi, Regina C De M ^a   Amed, Abes M ^a   Salomão, Reinaldo ^a   Kallás, Esper G ^a   De Moraes Pinto, Maria Isabel ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Gestation; HAART; HIV; Immunophenotyping

Indexed keywords

ANTIRETROVIRUS AGENT; CD3 ANTIGEN; CD38 ANTIGEN; CD4 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; EFAVIRENZ; INTERLEUKIN 7; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ADOLESCENT; ADULT; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COUNT; CHILDBIRTH; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOLYSIS; DELIVERY; EFFECTOR CELL; FEMALE; FLOW CYTOMETRY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOPHENOTYPING; NATURAL KILLER CELL; NONHUMAN; PREGNANT WOMAN; PRIORITY JOURNAL; VIREMIA; VIRUS LOAD;

ADOLESCENT; ADULT; ANTIGENS, CD38; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; HIV INFECTIONS; HIV SEROPOSITIVITY; HIV-1; HUMANS; IMMUNOPHENOTYPING; INTERLEUKIN-7; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; T-LYMPHOCYTE SUBSETS; VIRAL LOAD; VIREMIA;

EID: 47549090827     PISSN: 15524949     EISSN: 15524957     Source Type: Journal    
DOI: 10.1002/cyto.b.20418     Document Type: Article

References (31)

1. UNAIDS. Overview of the global AIDS epidemic. In: Report on the global AIDS epidemic: executive summary. A UNAIDS 10th anniversary special edition. Switzerland UNAIDS/WHO 2006; pp 8-43. Available at: http://data.unaids.org/pub/ globalReport/2006/2006_GR_CH02_en.pdf Accessed: May 3, 2007.
2. Quinn TC, Overbaugh J. HIV/AIDS in women: An expanding epidemic. Science 2005;308:1582-1583.
3. Blair JM, Hanson DL, Jones JL, Dworkin MS and Adult/Adolescent Spectrum of HIV Disease Project Group. Trends in pregnancy rates among women with human immunodeficiency virus. Obstet Gynecol 2004;103:663-668.
4. Thorne C, Patel D, Fiore S, Peckham C, Newell ML, and the European Collaborative Study. Mother-to-chid transmission of HIV infection in the era of highly active antiretroviral therapy. Clin Infect Dis 2005;40:458-465.
5. Wegmann TG, Lin H, Guilbert L, Mosmann TL. Bidirectional cytokine interactions in the maternal-fetal relationship: Is successful pregnancy a TH2 phenomenon? Immunol Today 1993;14:353-356.
6. Trowsdale J, Betz AG. Mother's little helpers: Mechanisms of maternal-fetal tolerance. Nat Immunol 2006;7:241-246.
7. Mikyas Y, Aziz N, Harawa N, Gorre M, Neagos N, Nogueira M, Wafer D, Dillon M, Boyer PJ, Bryson YJ, Plaeger S. Immunologic activation during pregnancy: Serial measurement of lymphocyte phenotype and serum activation molecules in HIV-infected and uninfected women. J Reprod Immunol 1997;33:157-170.
8. Harari A, Rizzardi GP, Ellefsen K, Ciuffreda D, Kaufmann D, Telenti A, Sahli R, Tambussi G, Kaiser L, Lazzarin A, Perrin L, Pantaleo G. Analysis of HIV-1 and CMV-specific memory CD4 T-cell responses during primary and chronic infection. Blood 2002;100:1381-1387.
9. Geginat J, Lanzavecchia A, Sallusto F. Proliferation and differentiation potential of human CD8+ memory T cell subsets in response to antigen or homeostatic cytokines. Blood 2003;101:4260-4266.
10. Sloand E. Hematologic complications of HIV infection. AIDS Rev 2005;7:187-196.
11. Fiore S, Newell ML, Trabattoni D, Thorne C, Gray L, Savasi V, Tibaldi C, Ferrazzi E, Clerici M. Antiretroviral therapy-associated modulation of Th1 and Th2 immune responses in HIV-infected pregnant women. J Reprod Immunol 2006;70:143-150.
12. Juretic E, Gagro A, Vukelic V Petrovecki M. Maternal and neonatal lymphocyte subpopulations at delivery and 3 days pospartum: Increased coexpression of CD45 isoforms. Am J Reprod Immunol 2004;52:1-7.
13. Abbas AK, Lichtman AH. Cytokines. In: Abbas AK, Lichtman AH, editors. Cellular and Molecular Immunology, 5th ed. Philadelphia: Elsevier; 2003. pp 243-274.
14. Sindhu S, Toma E, Cordeiro P, Ahmad R, Morisset R, Menezes J. Relationship of in vivo and ex vivo levels of Th1 and Th2 cytokines with viremia in HAART patients with and without opportunistic infections. J Med Virol 2006;78:431-439.
15. Fauci AS. HIV and AIDS: 20 years of science. Nat Med 2003;9:839-843.
16. Paranjape RS. Immunopathogenesis of HIV infection. Indian J Med Res 2005;121:240-255.
17. Benito JM, López M, Lozano S, Ballesteros C, Martinez P, González-Lahoz J, Soriano VS. Differential upregulation of CD38 on different T-cell subsets may influence the ability to reconstitute CD4+ T cells under successful highly active antiretroviral therapy. J Acquir Immune Defic Syndr 2005;38:373-381.
18. Rowland-Jones S, Tan R, McMichael A. Role of cellular immunity in protection against HIV infection. Adv Immunol 1997;65:277-346.
19. Lichterfeld M, Yu XG, Waring MT, Mui SK, Johnston MN, Cohen D, Addo MM, Zaunders J, Alter G, Pae E, Strick D, Allen TM, Rosenberg ES, Walker BD, Altfeld M. HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8+ T cells producing both interferon-γ and tumor necrosis factor-α. Blood 2004;104:487-494.
20. Alter G, Malenfant JM, Delabre RM, Burgerte NC, Yu XG, Licheterfeld M, Zaunders J, Altfeld M. Increased natural killer cell activity in viremic HIV-1 infection. J Immunol 2004;173:5305-5311.
21. Ullum H, Gotzsche PC, Victor J, Dickmeiss E, Skinhoj P, Pedersen BK. Defective natural immunity an early manifestation of human immunodeficiency virus infection. J Exp Med 1995;182:789-799-
22. Douglas SD, Durako SJ, Tustin NB, Houser J, Muenz L, Starr SE, Wilson C. Natural killer cell enumeration and function in HIV-infected and high-risk uninfected adolescents. AIDS Res Hum Retroviruses 2001;17:543-552.
23. Müller E Tjonnfiord GE, Nordoy I, Kvate D, Mellbye OJ, Aukrust P, Froland SS. Immunophenotypic analyses of CD34+ cells subset in bone marrow from HIV-infected patients during highly active antretroviral therapy. Eur J Clin Invest 2002;32:535-540.
24. Zon LI, Arkin C, Groopman JE. Haematologic manifestations of the human immune deficiency virus (HIV). Br J Haematol 1987;66:251-256.
25. Banda NK, Tomczak JA, Shpall EJ, Akkina RK, Steimer KS, Hami L, Curiel TJ, Singer Harrison G. HIV-gp120 induced cell death in hematopoietic progenitor CD34+ cells. Apoptosis 1997;2:61-68.
26. Champagne P, Ogg GS, King AS, Knabenhans C, Ellefsen K, Nobile M, Appay V, Rizzardi GP, Fleury S, Lipp M, Forster R, Rowland-Jones S, Sekaly RP, McMichael AJ, Pantaleo G. Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature 2001;410:106-111.
27. Pittet MJ, Speiser DE, Valmori D, Cerottini JC, Romero R Cutting edge: Cytolytic effector function in human circulating CD8+ T cells closely correlates with CD56 surface expression. J Immunol 2000;164:1148-1152.
28. Fry TJ, Mackall CL. Interleukin-7: From bench to clinic. Blood 2002;99:3892-3904.
29. Ruiz-Mateos E, de la Rosa R, Franco JM, Martinez-Moya M, Rubio A, Soriano N, Sanchez-Quijano A, Lissen E, Leal M. Endogenous IL-7 is associated with increase thymic volume in adult HIV-infected patients under highly active antiretroviral therapy. AIDS 2003;17:947-954.
30. Connor EM, Sperling RS, Gelber R, Kiselev P, Scott G, O'Sullivan MJ, VanDyke R, Bey M, Shearer W, Jacobson RL, Jimenez E, O'Neill E, Bazin B, Delfraissy JF, Culnane M, Coombs R, Elkins M, Moye J, Stratton P, Baisley J; for the Pediatric AIDS Clinical Trials Group. Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. New Engl J Med 1994;331:1173-1180.
31. Rodríguez B, Sethi AK, Cheruvu VK, Boswell SL, Mathews WC, Bangsberg DR, Martin J, Whalen CC, Sieg S, Yadavalli S, Deeks SG, Lederman MM. Predictive value of plasma HIV RNA level on rate of CD4 T-cell decline in untreated HIV infection. JAMA 2006;296:1498-1506.