Paper by Invitation: Imaging Idiopathic Generalized Epilepsy

Clinical EEG and Neuroscience

Volumn 35, Issue 4, 2004, Pages 168-172

  Duncan, John S ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Functional MRI (fMRI); Idiopathic generalized epilepsy (IGE); Magnetic resonance imaging (MRI); Magnetic resonance spectroscopy (MRS); Positron emission tomography (PET); Single photon emission computed tomography (SPECT)

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; CHOLINE; CREATINE; DELTA OPIATE RECEPTOR; ENDORPHIN; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; HOMOCARNOSINE; INOSITOL; KAPPA OPIATE RECEPTOR; LIGAND; MU OPIATE RECEPTOR; N ACETYLASPARTIC ACID; OPIATE; TRACER;

4 AMINOBUTYRIC ACID BRAIN LEVEL; ARTICLE; BRAIN BLOOD FLOW; CELL ACTIVATION; CONSENSUS; ELECTROENCEPHALOGRAM; FRONTAL LOBE; FUNCTIONAL ANATOMY; GENERALIZED EPILEPSY; GLUCOSE BRAIN LEVEL; GLUCOSE METABOLISM; HUMAN; IDIOPATHIC DISEASE; NEOCORTEX; NERVE CELL; NERVE CELL LESION; NEUROCHEMISTRY; NEUROIMAGING; NEUROPHYSIOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OCCIPITAL LOBE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; THALAMUS;

CEREBROVASCULAR CIRCULATION; DIAGNOSTIC IMAGING; EPILEPSY, GENERALIZED; HUMANS; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; TOMOGRAPHY, EMISSION-COMPUTED; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 4744368355     PISSN: 15500594     EISSN: None     Source Type: Journal    
DOI: 10.1177/155005940403500405     Document Type: Article

References (36)

1. Gloor P. Generalized epilepsy with spike-and-wave discharge: A reinterpretation of its electrographic and clinical manifestations. The 1977 William G. Lennox Lecture, American Epilepsy Society. Epilepsia 1979; 20: 571-588.
2. Blumenfeld H. From molecules to networks: Cortical/subcortical interactions in the pathophysiology of idiopathic generalized epilepsy. Epilepsia 2003; 44 (suppl 2): 7-15.
3. Savic I Seitz RJ Pauli S. Brain distortions in patients with primarily generalized tonic-clonic seizures. Epilepsia 1998; 39: 364-370.
4. Woermann FG Sisodiya SM Free SL Duncan JS. Quantitative MRI in patients with idiopathic generalized epilepsy: Evidence of widespread cerebral structural changes. Brain 1998; 121 (Pt 9): 1661-1667.
5. Woermann FG Free SL Koepp MJ Ashburner J Duncan JS. Voxel-by-voxel comparison of automatically segmented cerebral gray matter: A rater-independent comparison of structural MRI in patients with epilepsy. Neuroimage. 1999, 10: 373-384.
6. Woermann FG Free SL Koepp MJ Sisodiya SM Duncan JS. Abnormal cerebral structure in juvenile myoclonic epilepsy demonstrated with voxel-based analysis of MRI. Brain 1999: 122 (Pt 11): 2101-2108.
7. Bernasconi A Bernasconi N Natsume J Antel SB Andermann F Arnold DL. Magnetic resonance spectroscopy and imaging of the thalamus in idiopathic generalized epilepsy. Brain 2003; 126: 2447-2454.
8. Natsume J Bernasconi N Andermann F Bernasconi A. MRI volumetry of the thalamus in temporal, extratemporal, and idiopathic generalized epilepsy. Neurology 2003; 60: 1296-1300.
9. Bernasconi N Andermann F Arnold DL Bernasconi A. Entorhinal cortex MRI assessment in temporal, extratemporal, and idiopathic generalized epilepsy. Epilepsia 2003; 44: 1070-1074.
10. Savic I Lekvall A Greitz D Helms G. MR spectroscopy shows reduced frontal lobe concentrations of N-acetyl aspartate in patients with juvenile myoclonic epilepsy. Epilepsia 2000; 41: 290-296.
11. Savic I Osterman Y Helms G. MRS shows syndrome differentiated metabolite changes in human-generalized epilepsies. Neuroimage. 2004; 21: 163-172.
12. Mory SB Li LM Guerreiro CA Cendes F. Thalamic dysfunction in juvenile myoclonic epilepsy: A proton MRS study. Epilepsia 2003; 44: 1402-1405.
13. Simister RJ McLean MA Barker GJ Duncan JS. A proton magnetic resonance spectroscopy study of metabolites in the occipital lobes in epilepsy. Epilepsia 2003; 44: 550-558.
14. Petroff OA Hyder F Rothman DL Mattson RH. Homocarnosine and seizure control in juvenile myoclonic epilepsy and complex partial seizures. Neurology 2001; 56: 709-715.
15. Simister RJ McLean MA Barker GJ Duncan JS. Proton MRS reveals frontal lobe metabolite abnormalities in idiopathic generalized epilepsy. Neurology 2003; 61: 897-902.
16. Prevett MC Duncan JS Jones T Fish DR Brooks DJ. Demonstration of thalamic activation during typical absence seizures using H2(15)O and PET. Neurology 1995; 45: 1396-1402.
17. Yeni SN Kabasakal L Yalcinkaya C Nisli C Dervent A. Ictal and interictal SPECT findings in childhood absence epilepsy. Seizure 2000; 9: 265-269.
18. Sanada S Murakami N Ohtahara S. Changes in blood flow of the middle cerebral artery during absence seizures. Pediatr Neurol 1988; 4: 158-161.
19. Nehlig A Vergnes M Waydelich R Hirsch E Charbonne R Marescaux C, et al. Absence seizures induce a decrease in cerebral blood flow: Human and animal data. J Cereb Blood FlowMetab 1996; 16: 147-155.
20. De Simone R Silvestrini M Marciani MG Curatolo P. Changes in cerebral blood flow velocities during childhood absence seizures. Pediatr Neurol 1998; 18: 132-135.
21. Salek-Haddadi A Lemieux L Merschhemke M Friston KJ Duncan JS Fish DR. Functional magnetic resonance imaging of human absence seizures. Ann Neurol 2003; 53: 663-667.
22. Archer JS Abbott DF Waites AB Jackson GD. fMRI “deactivation” of the posterior cingulate during generalized spike and wave. Neuroimage 2003; 20: 1915-1922.
23. Aghakhani Y Bagshaw AP Benar CG Hawco C Andermann F Dubeau F, et al. fMRI activation during spike and wave discharges in idiopathic generalized epilepsy. Brain 2004 May;127(Pt5): 1127-1144.
24. Tenney JR Duong TQ King JA Ludwig R Ferris CF. Corticothalamic modulation during absence seizures in rats: A functional MRI assessment. Epilepsia 2003; 44: 1133-1140.
25. Nehlig A Vergnes M Marescaux C Boyet S Lannes B. Local cerebral glucose utilization in rats with petit mal-like seizures. Ann Neurol 1991; 29: 72-77.
26. Theodore WH Brooks R Margolin R Patronas N Sato S Porter RJ, et al. Positron emission tomography in generalized seizures. Neurology 1985; 35: 684-690.
27. Engel J Jr Lubens P Kuhl DE Phelps ME. Local cerebral metabolic rate for glucose during petit mal absences. Ann Neurol 1985; 17: 121-128.
28. Ochs RF Gloor P Tyler JL Wolfson T Worsley K Andermann F, et al. Effect of generalized spike-and-wave discharge on glucose metabolism measured by positron emission tomography. Ann Neurol 1987; 21: 458-464.
29. Savic I Widen L Thorell JO Blomqvist G Ericson K Roland P. Cortical benzodiazepine receptor binding in patients with generalized and partial epilepsy. Epilepsia 1990; 31: 724-730.
30. Savic I Pauli S Thorell JO Blomqvist G. In vivo demonstration of altered benzodiazepine receptor density in patients with generalized epilepsy. J Neurol Neurosurg Psychiatry 1994; 57: 797-804.
31. Prevett MC Lammertsma AA Brooks DJ Bartenstein PA Patsalos PN Fish DR, et al. Benzodiazepine-GABAA receptors in idiopathic generalized epilepsy measured with [11C]flumazenil and positron emission tomography. Epilepsia 1995; 36: 113-121.
32. Koepp MJ Richardson MP Brooks DJ Cunningham VJ Duncan JS. Central benzodiazepine/gamma-aminobutyric acid A receptors in idiopathic generalized epilepsy: An [11C]flumazenil positron emission tomography study. Epilepsia 1997; 38: 1089-1097.
33. Meencke HJ Veith G. Migration disturbances in epilepsy. Epilepsy Res Suppl 1992; 9: 31-39.
34. Prevett MC Lammertsma AA Brooks DJ Cunningham VJ Fish DR Duncan JS. Benzodiazepine-GABAA receptor binding during absence seizures. Epilepsia 1995; 36: 592-599.
35. Prevett MC Cunningham VJ Brooks DJ Fish DR Duncan JS. Opiate receptors in idiopathic generalized epilepsy measured with [11C]diprenorphine and positron emission tomography. Epilepsy Res 1994; 19: 71-77.
36. Bartenstein PA Duncan JS Prevett MC Cunningham VJ Fish DR Jones AK, et al. Investigation of the opioid system in absence seizures with positron emission tomography. J Neurol Neurosurg Psychiatry 1993; 56: 1295-1302.