Quantitative MRI in patients with idiopathic generalized epilepsy. Evidence of widespread cerebral structural changes

Brain

Volumn 121, Issue 9, 1998, Pages 1661-1667

  Woermann, F G ^a   Sisodiya, S M ^a,b   Free, S L ^a   Duncan, J S ^a,c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b RADCLIFFE INFIRMARY   (United Kingdom)

^c NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

Author keywords

Idiopathic generalized epilepsy; Morphometry; MRI

Indexed keywords

ABSENCE; ADOLESCENT; ADULT; ARTICLE; AUTOPSY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENERALIZED EPILEPSY; GRAY MATTER; HUMAN; IDIOPATHIC DISEASE; MALE; MYOCLONUS EPILEPSY; NEUROPATHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; TONIC CLONIC SEIZURE; WHITE MATTER;

EID: 0031661116     PISSN: 00068950     EISSN: None     Source Type: Journal    
DOI: 10.1093/brain/121.9.1661     Document Type: Article

References (26)

1. Berkovic SF, Howell RA, Hay DA, Hopper JL. Epilepsies in twins. In: Wolf P, editor. Epileptic seizures and syndromes. London: John Libbey; 1994. p. 157-64.
2. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986; 327: 307-10.
3. Caviness VS, Kennedy DN, Bates JE, Makris N. The developing human brain: a morphometric profile. In: Thatcher RW, Reid-Lyon G, Rumsey J, Krasnegov N, editors Developmental neuroimaging. Mapping the development of brain and behavior. San Diego: Academic Press; 1996. p. 3-14.
4. Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for classification of epilepsies and epileptic syndromes. Epilepsia 1985; 26: 268-78.
5. Elmslie FV, Rees M, Williamson MP, Kerr M, Kjeldsen MJ, Pang KA, et al. Genetic mapping of a major susceptibility locus for juvenile myoclonic epilepsy on chromosome 15q. Hum Mol Genet 1997;6: 1329-34.
6. Ferrer I, Pineda M, Tallada M, Oliver B, Russi A, Oller L, et al. Abnormal local-circuit neurons in epilepsia partialis continua associated with focal cortical dysplasia. Acta Neuropathol (Berl) 1992; 83: 647-52.
7. Gloor P. Feline generalised penicillin epilepsy: extrapolations to neurophysiological mechanisms in humans. In: Duncan JS, Panayiotopoulos CP, editors. Typical absences and related epileptic syndromes. London; Churchill Communications Europe; 1995. p. 74-82.
8. Huttenlocher PR. Dendritic development in neocortex of children with mental defect and infantile spasms. Neurology 1974; 24: 203-10.
9. Janz D, Neimanis G. Clinico-anatomical study of a case of idiopathic epilepsy with impulsive petit mal ('Impulsiv-Petit mal') and Grand Mal on awakening ('Aufwach-Grand mal'). Epilepsia 1961; 2: 251-69.
10. 11C]flumazenil positron emission tomography study. Epilepsia 1997: 38: 1089-97.
11. Lyon G, Gastaut H. Considerations on the significance attributed to unusual cerebral histological findings recently described in eight patients with primary generalized epilepsy. Epilepsia 1985; 26: 365-7.
12. Meencke HJ. Neuron density in the molecular layer of the frontal cortex in primary generalized epilepsy. Epilepsia 1985; 26: 450-4.
13. Meencke HJ, Janz D. Neuropathological findings in primary generalized epilepsy: a study of eight cases. Epilepsia 1984; 25: 8-21.
14. Mitchison G. Neuronal branching patterns and the economy of cortical wiring. Proc R Soc Lond B Biol Sci 1991; 245: 151-8.
15. Niedermeyer E. Primary (idiopathic) generalized epilepsy and underlying mechanisms. Clin Electroencephalogr 1996; 27: 1-21.
16. Palmini A, Gambardella A, Andermann F, Dubeau F, Dacosta JC, Olivier A, et al. Intrinsic epileptogenicity of human dysplastic cortex as suggested by corticography and surgical results. Ann Neurol 1995; 37: 476-87.
17. 15O and PET. Neurology 1995; 45: 1396-402.
18. Savic I, Pauli S, Thorell JO, Blomqvist G. In vivo demonstration of altered benzodiazepine receptor density in patients with generalised epilepsy. J Neurol Neurosurg Psychiatry 1994; 57: 797-804.
19. Serratosa JM, Delgado-Escueta AV, Medina MT, Zhang Q, Iranmanesh R, Sparkes RS. Clinical and genetic analysis of a large pedigree with juvenile myoclonic epilepsy. Ann Neurol 1996; 39: 187-95.
20. Sisodiya SM, Free SL. Disproportion of cerebral surface areas and volumes in cerebral dysgenesis. MRI-based evidence for connectional abnormalities. Brain 1997; 120: 271-81.
21. Sisodiya SM, Free SL, Stevens JM, Fish DR, Shorvon SD. Widespread cerebral structural changes in patients with cortical dysgenesis and epilepsy. Brain 1995; 118: 1039-50.
22. Sisodiya SM, Moran N, Free SL, Kitchen ND, Stevens JM, Harkness WF, et al. Correlation of widespread preoperative magnetic resonance imaging changes with unsuccessful surgery for hippocampal sclerosis. Ann Neurol 1997; 41: 490-6.
23. 18FDG PET study. Neurology 1996; 47: 1203-12.
24. Takada K, Becker LE, Chan F. Aberrant dendritic development in the human agyric cortex: a quantitative and qualitative Golgi study of two cases. Clin Neuropathol 1988; 7: 111-9.
25. Velasco M, Velasco F, Velasco AL, Luján M, Vasquez del Mercado J. Epileptiform EEG activities of the centromedian thalamic nuclei in patients with intractable partial motor, complex partial, and generalized seizures. Epilepsia 1989; 30: 295-306.
26. Williams D. A study of thalamic and cortical rhythms in petit mal. Brain 1953; 76: 50-69.