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Volumn 129, Issue 1-2, 2004, Pages 163-170

Regulation of microtubule-associated proteins, protein kinases and protein phosphatases during differentiation of SY5Y cells

Author keywords

Cell differentiation and migration; Cytoskeletal proteins; Development and regeneration; Differentiation; Microtubule associated proteins; Protein kinases; Protein phosphatases; Tau phosphorylation

Indexed keywords

CREATINE KINASE BB; CYCLIN DEPENDENT KINASE 5; MICROTUBULE ASSOCIATED PROTEIN 2; MICROTUBULE ASSOCIATED PROTEIN 5; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE; PROTEIN KINASE C; SERINE; TAU PROTEIN;

EID: 4744345863     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbrainres.2004.07.001     Document Type: Article
Times cited : (12)

References (52)
  • 1
    • 0028227962 scopus 로고
    • Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease
    • A. d-C. Alonso, T. Zaidi, and I. Grundke-Iqbal Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease Proc. Natl. Acad. Sci. U. S. A. 91 1994 5562 5566
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 5562-5566
    • Alonso-del, A.C.1    Zaidi, T.2    Grundke-Iqbal, I.3
  • 2
    • 0029999787 scopus 로고    scopus 로고
    • Alzheimer disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules
    • A.d-C. Alonso, I. Grundke-Iqbal, and K. Iqbal Alzheimer disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules Nat. Med. 2 1996 783 787
    • (1996) Nat. Med. , vol.2 , pp. 783-787
    • Alonso, A.d-C.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 3
    • 0029037696 scopus 로고
    • Bovine and human tau, highly homologous but less crossreactive: Implications for Alzheimer disease
    • A. d-C. Alonso, I. Grundke-Iqbal, and K. Iqbal Bovine and human tau, highly homologous but less crossreactive: implications for Alzheimer disease Brain Res. 31 1995 194 200
    • (1995) Brain Res. , vol.31 , pp. 194-200
    • A, D.-C.A.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 4
    • 0031012497 scopus 로고    scopus 로고
    • Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: Sequestration of MAP1 and MAP2 and the disassembly of microtubules by the abnormal tau
    • A.d-C. Alonso, I. Grundke-Iqbal, H.S. Barra, and K. Iqbal Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of MAP1 and MAP2 and the disassembly of microtubules by the abnormal tau Proc. Natl. Acad. Sci. U. S. A. 94 1997 298 303
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 298-303
    • Alonso, A.d-C.1    Grundke-Iqbal, I.2    Barra, H.S.3    Iqbal, K.4
  • 5
    • 0035830740 scopus 로고    scopus 로고
    • Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356
    • M. Bennecib, C.-X. Gong, I. Grundke-Iqbal, and K. Iqbal Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356 FEBS Lett. 490 2001 15 22
    • (2001) FEBS Lett. , vol.490 , pp. 15-22
    • Bennecib, M.1    Gong, C.-X.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 6
    • 0027338266 scopus 로고
    • 262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding
    • 262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding Neuron 11 1993 153 163
    • (1993) Neuron , vol.11 , pp. 153-163
    • Biernat, J.1    Gustke, N.2    Drewes, G.3    Mandelkow, E.-M.4    Mandelkow, E.5
  • 7
    • 0027453116 scopus 로고
    • Attenuation of MAP1B (MAP5) expression by antisense oligodeoxynuclestides inhibits initiation neurite outgrowth
    • B. Brugg, D. Reddy, and A. Matus Attenuation of MAP1B (MAP5) expression by antisense oligodeoxynuclestides inhibits initiation neurite outgrowth Neuroscience 52 1993 489 496
    • (1993) Neuroscience , vol.52 , pp. 489-496
    • Brugg, B.1    Reddy, D.2    Matus, A.3
  • 8
    • 0015912123 scopus 로고
    • The subunit structure of rabbit-skeletal-muscle phosphorylase kinase, and the molecular basis of its activation reactions
    • P. Cohen the subunit structure of rabbit-skeletal-muscle phosphorylase kinase, and the molecular basis of its activation reactions Eur. J. Biochem. 34 1973 1 14
    • (1973) Eur. J. Biochem. , vol.34 , pp. 1-14
    • Cohen, P.1
  • 10
    • 0028937631 scopus 로고
    • Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). a novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262
    • G. Drewes, B. Trinczek, S. Illenberger, J. Biernat, G. Schmitt-Ulms, H.E. Meyer, E.M. Mandelkow, and E. Mandelkow Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262 J. Biol. Chem. 31 1995 7679 7688
    • (1995) J. Biol. Chem. , vol.31 , pp. 7679-7688
    • Drewes, G.1    Trinczek, B.2    Illenberger, S.3    Biernat, J.4    Schmitt-Ulms, G.5    Meyer, H.E.6    Mandelkow, E.M.7    Mandelkow, E.8
  • 11
    • 0030217953 scopus 로고    scopus 로고
    • Human microtubule-associated protein 1a (MAP1A) gene: Genomic organization, cDNA sequence, and developmental- and tissue-specific expression
    • J.K. Fink, S.M. Jones, C. Esposito, and J. Wilkowski Human microtubule-associated protein 1a (MAP1A) gene: genomic organization, cDNA sequence, and developmental- and tissue-specific expression Genomics 35 1996 577 585
    • (1996) Genomics , vol.35 , pp. 577-585
    • Fink, J.K.1    Jones, S.M.2    Esposito, C.3    Wilkowski, J.4
  • 12
    • 0025310594 scopus 로고
    • Molecular cloning of microtubule-associated protein 1 (MAP1A) and microtubule-associated protein 5 (MAP1B): Identification of distinct genes and their differential expression in developing brain
    • C.C. Garner, A. Garner, G. Huber, C. Kozak, and A. Matus Molecular cloning of microtubule-associated protein 1 (MAP1A) and microtubule-associated protein 5 (MAP1B): identification of distinct genes and their differential expression in developing brain J. Neurochem. 55 1990 146 154
    • (1990) J. Neurochem. , vol.55 , pp. 146-154
    • Garner, C.C.1    Garner, A.2    Huber, G.3    Kozak, C.4    Matus, A.5
  • 13
    • 0028064431 scopus 로고
    • Dephosphorylation of Alzheimer disease abnormally phosphorylated tau by protein phosphatase-2A
    • C.-X. Gong, I. Grundke-Iqbal, and K. Iqbal Dephosphorylation of Alzheimer disease abnormally phosphorylated tau by protein phosphatase-2A Neuroscience 61 1994 765 772
    • (1994) Neuroscience , vol.61 , pp. 765-772
    • Gong, C.-X.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 14
    • 0028350740 scopus 로고
    • Dephosphorylation of microtubule-associated protein tau by protein phosphatase-1 and -2C and its implication in Alzheimer disease
    • C.-X. Gong, I. Grundke-Iqbal, Z. Damuni, and K. Iqbal Dephosphorylation of microtubule-associated protein tau by protein phosphatase-1 and -2C and its implication in Alzheimer disease FEBS Lett. 341 1994 94 98
    • (1994) FEBS Lett. , vol.341 , pp. 94-98
    • Gong, C.-X.1    Grundke-Iqbal, I.2    Damuni, Z.3    Iqbal, K.4
  • 15
    • 0030602070 scopus 로고    scopus 로고
    • Inhibition of protein phosphatase-2B (calcineurin) activity towards Alzheimer abnormally phosphorylated tau by neuroleptics
    • C.-X. Gong, S. Shaikh, I. Grundke-Iqbal, and K. Iqbal Inhibition of protein phosphatase-2B (calcineurin) activity towards Alzheimer abnormally phosphorylated tau by neuroleptics Brain Res. 741 1996 95 102
    • (1996) Brain Res. , vol.741 , pp. 95-102
    • Gong, C.-X.1    Shaikh, S.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 16
    • 0034088846 scopus 로고    scopus 로고
    • Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain: Implications for neurofibrillary degeneration in Alzheimer disease
    • C.-X. Gong, T. Lidsky, J. Wegiel, L. Zuck, I. Grundke-Iqbal, and K. Iqbal Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain: implications for neurofibrillary degeneration in Alzheimer disease J. Biol. Chem. 275 2000 5535 5544
    • (2000) J. Biol. Chem. , vol.275 , pp. 5535-5544
    • Gong, C.-X.1    Lidsky, T.2    Wegiel, J.3    Zuck, L.4    Grundke-Iqbal, I.5    Iqbal, K.6
  • 17
    • 0033986391 scopus 로고    scopus 로고
    • Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain
    • G.-X. Gong, J. Wegiel, T. Lidsky, L. Zuck, J. Avila, H.M. Wisniewski, I. Grundke-Iqbal, and K. Iqbal Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain Brain Res. 853 2000 299 309
    • (2000) Brain Res. , vol.853 , pp. 299-309
    • Gong, G.-X.1    Wegiel, J.2    Lidsky, T.3    Zuck, L.4    Avila, J.5    Wisniewski, H.M.6    Grundke-Iqbal, I.7    Iqbal, K.8
  • 18
    • 0032748099 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3β phosphorylation of microtubule- associated protein 1B regulates the stability of microtubules in growth cones
    • R.G. Goold, R. Owen, and P.R. Gordon-Weeks Glycogen synthase kinase 3β phosphorylation of microtubule-associated protein 1B regulates the stability of microtubules in growth cones J. Cell Sci. 112 1999 3373 3384
    • (1999) J. Cell Sci. , vol.112 , pp. 3373-3384
    • Goold, R.G.1    Owen, R.2    Gordon-Weeks, P.R.3
  • 22
    • 0033554182 scopus 로고    scopus 로고
    • Regulation of expression, phosphorylation and biological activity of tau during differentiation in SY5Y cells
    • N. Haque, T. Tanaka, K. Iqbal, and I. Grundke-Iqbal Regulation of expression, phosphorylation and biological activity of tau during differentiation in SY5Y cells Brain Res. 838 1999 69 77
    • (1999) Brain Res. , vol.838 , pp. 69-77
    • Haque, N.1    Tanaka, T.2    Iqbal, K.3    Grundke-Iqbal, I.4
  • 23
    • 0022724941 scopus 로고
    • Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease
    • Y. Ihara, N. Nukina, R. Miura, and M. Ogawara Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease J. Biochem. (Tokyo) 99 1986 1807 1810
    • (1986) J. Biochem. (Tokyo) , vol.99 , pp. 1807-1810
    • Ihara, Y.1    Nukina, N.2    Miura, R.3    Ogawara, M.4
  • 24
    • 0025856776 scopus 로고
    • A serine/threonine proline kinase activity is included in the tau protein kinase fraction forming a paired helical filament epitope
    • K. Ishiguro, A. Omori, K. Sato, K. Tomizawa, K. Imahori, and T. Uchida A serine/threonine proline kinase activity is included in the tau protein kinase fraction forming a paired helical filament epitope Neurosci. Lett. 128 1991 195 198
    • (1991) Neurosci. Lett. , vol.128 , pp. 195-198
    • Ishiguro, K.1    Omori, A.2    Sato, K.3    Tomizawa, K.4    Imahori, K.5    Uchida, T.6
  • 25
    • 0009623452 scopus 로고
    • Modification to microtubule steady state dynamics by phosphorylation of the microtubule-associated proteins
    • L. Jameson, and M. Caplow Modification to microtubule steady state dynamics by phosphorylation of the microtubule-associated proteins Proc. Natl. Acad. Sci. U. S. A. 78 1981 3413 3417
    • (1981) Proc. Natl. Acad. Sci. U. S. A. , vol.78 , pp. 3413-3417
    • Jameson, L.1    Caplow, M.2
  • 26
    • 0033302735 scopus 로고    scopus 로고
    • Tau protein in normal and Alzheimer disease brain: An update
    • G.V.W. Johnson, and J.A. Hartigan Tau protein in normal and Alzheimer disease brain: an update J. Alzheimer's Dis. 1 1999 329 351
    • (1999) J. Alzheimer's Dis. , vol.1 , pp. 329-351
    • Johnson, G.V.W.1    Hartigan, J.A.2
  • 27
    • 0026694783 scopus 로고
    • Brain levels of microtubule associated protein tau are elevated in Alzheimer's disease brain: A radio-immuno-slot-blot assay for nanograms of the protein
    • S. Khatoon, I. Grundke-Iqbal, and K. Iqbal Brain levels of microtubule associated protein tau are elevated in Alzheimer's disease brain: a radio-immuno-slot-blot assay for nanograms of the protein J. Neurochem. 59 1992 750 753
    • (1992) J. Neurochem. , vol.59 , pp. 750-753
    • Khatoon, S.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 28
    • 0028095224 scopus 로고
    • Levels of normal and abnormally phosphorylated tau in different cellular and regional components of Alzheimer disease and control brains
    • S. Khatoon, I. Grundke-Iqbal, and K. Iqbal Levels of normal and abnormally phosphorylated tau in different cellular and regional components of Alzheimer disease and control brains FEBS Lett. 351 1994 80 84
    • (1994) FEBS Lett. , vol.351 , pp. 80-84
    • Khatoon, S.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 29
    • 0030723127 scopus 로고    scopus 로고
    • Casein kinase 1 is tightly associated with paired-helical filaments isolated from Alzheimer disease brain
    • J. Kuret, G.S. Johnson, D. Cha, E.R. Christenson, A.J. DeMaggio, and M.F. Hoekstra Casein kinase 1 is tightly associated with paired-helical filaments isolated from Alzheimer disease brain J. Neurochem. 69 1997 2506 2515
    • (1997) J. Neurochem. , vol.69 , pp. 2506-2515
    • Kuret, J.1    Johnson, G.S.2    Cha, D.3    Christenson, E.R.4    Demaggio, A.J.5    Hoekstra, M.F.6
  • 30
    • 0026737638 scopus 로고
    • Microtubule-associated protein 1A and LC2: Two proteins encoded in one messenger RNA
    • A. Langkopf, J.A. Hammerback, R. Mutter, R.B. Vallee, and C.G. Garner Microtubule-associated protein 1A and LC2: two proteins encoded in one messenger RNA J. Biol. Chem. 267 1992 16561 16565
    • (1992) J. Biol. Chem. , vol.267 , pp. 16561-16565
    • Langkopf, A.1    Hammerback, J.A.2    Mutter, R.3    Vallee, R.B.4    Garner, C.G.5
  • 31
    • 0021338217 scopus 로고
    • Phosphorylation affects the ability of tau protein to promote microtubule assembly
    • G. Lindwall, and R.D. Cole Phosphorylation affects the ability of tau protein to promote microtubule assembly J. Biol. Chem. 259 1984 5301 5305
    • (1984) J. Biol. Chem. , vol.259 , pp. 5301-5305
    • Lindwall, G.1    Cole, R.D.2
  • 32
    • 0037049240 scopus 로고    scopus 로고
    • Aberrant glycosylation modulates phosphorylation of tau by protein kinase a and dephosphorylation by protein phosphatase 2A and 5
    • F. Liu, T. Zaidi, K. Iqbal, I. Grundke-Iqbal, and C.-X. Gong Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation by protein phosphatase 2A and 5 Neuroscience 115 2002 829 837
    • (2002) Neuroscience , vol.115 , pp. 829-837
    • Liu, F.1    Zaidi, T.2    Iqbal, K.3    Grundke-Iqbal, I.4    Gong, C.-X.5
  • 33
    • 0037163879 scopus 로고    scopus 로고
    • Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3β
    • F. Liu, K. Iqbal, I. Grundke-Iqbal, and C.-X. Gong Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3β FEBS Lett. 530 2002 209 214
    • (2002) FEBS Lett. , vol.530 , pp. 209-214
    • Liu, F.1    Iqbal, K.2    Grundke-Iqbal, I.3    Gong, C.-X.4
  • 34
    • 0028140113 scopus 로고
    • Coordinate regulation of tubulin and microtubule associated protein genes during development of hamster brain
    • M.O. Oblinger, and S.A. Kost Coordinate regulation of tubulin and microtubule associated protein genes during development of hamster brain Dev. Brain Res. 77 1994 45 54
    • (1994) Dev. Brain Res. , vol.77 , pp. 45-54
    • Oblinger, M.O.1    Kost, S.A.2
  • 35
    • 0027421625 scopus 로고
    • Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer paired helical filaments
    • H.K. Paudel, J. Lew, Z. Ali, and J.H. Wang Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer paired helical filaments J. Biol. Chem. 268 1993 23512 23518
    • (1993) J. Biol. Chem. , vol.268 , pp. 23512-23518
    • Paudel, H.K.1    Lew, J.2    Ali, Z.3    Wang, J.H.4
  • 36
    • 0029869272 scopus 로고    scopus 로고
    • Characterization of microtubule-associated protein MAP1B: Phosphorylation state, light chain, and binding to microtubules
    • B. Pedrotti, L. Ulloa, J. Avila, and K. Islam Characterization of microtubule-associated protein MAP1B: phosphorylation state, light chain, and binding to microtubules Biochemistry 35 1996 3016 3023
    • (1996) Biochemistry , vol.35 , pp. 3016-3023
    • Pedrotti, B.1    Ulloa, L.2    Avila, J.3    Islam, K.4
  • 37
    • 0032578024 scopus 로고    scopus 로고
    • Accumulation of cyclin-dependent kinase 5 (cdk6) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration
    • J.-J. Pei, I. Grundke-Iqbal, K. Iqbal, N. Bogdanovic, B. Winblad, and R.F. Cowburn Accumulation of cyclin-dependent kinase 5 (cdk6) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration Brain Res. 797 1998 267 277
    • (1998) Brain Res. , vol.797 , pp. 267-277
    • Pei, J.-J.1    Grundke-Iqbal, I.2    Iqbal, K.3    Bogdanovic, N.4    Winblad, B.5    Cowburn, R.F.6
  • 38
    • 12244279939 scopus 로고    scopus 로고
    • Up-regulation of mitogen activated protein kinase kinase and mitogen activated protein kinase is associated with the progression of Alzheimer's disease neurofibrillary degeneration
    • J.-J. Pei, H. Braak, W.-L. An, I. Grundke-Iqbal, K. Iqbal, B. Winblad, and R.F. Cowburn Up-regulation of mitogen activated protein kinase kinase and mitogen activated protein kinase is associated with the progression of Alzheimer's disease neurofibrillary degeneration Mol. Brain Res. 109 2002 45 53
    • (2002) Mol. Brain Res. , vol.109 , pp. 45-53
    • Pei, J.-J.1    Braak, H.2    An, W.-L.3    Grundke-Iqbal, I.4    Iqbal, K.5    Winblad, B.6    Cowburn, R.F.7
  • 39
    • 0042679509 scopus 로고    scopus 로고
    • Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease
    • J.J. Pei, C.-X. Gong, W.-L. An, B. Winblad, R.F. Cowburn, I. Grundke-Iqbal, and K. Iqbal Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease Am. J. Pathol. 163 2003 845 858
    • (2003) Am. J. Pathol. , vol.163 , pp. 845-858
    • Pei, J.J.1    Gong, C.-X.2    An, W.-L.3    Winblad, B.4    Cowburn, R.F.5    Grundke-Iqbal, I.6    Iqbal, K.7
  • 40
    • 0022972987 scopus 로고
    • MAP5: A novel brain microtubule-associated protein under strong developmental regulation
    • B. Riederer, R. Cohen, and A. Matus MAP5: a novel brain microtubule-associated protein under strong developmental regulation J. Neurocytol. 15 1986 763 775
    • (1986) J. Neurocytol. , vol.15 , pp. 763-775
    • Riederer, B.1    Cohen, R.2    Matus, A.3
  • 41
    • 0034622242 scopus 로고    scopus 로고
    • Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases
    • M. Schwab, A.J. DeMaggio, N. Ghloshal, L.I. Binder, J. Kuret, and I. McGeer Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases Neurobiol. Aging 4 2000 503 510
    • (2000) Neurobiol. Aging , vol.4 , pp. 503-510
    • Schwab, M.1    Demaggio, A.J.2    Ghloshal, N.3    Binder, L.I.4    Kuret, J.5    McGeer, I.6
  • 42
    • 0032530145 scopus 로고    scopus 로고
    • Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules
    • A. Sengupta, J. Kabat, M. Novak, Q. Wu, I. Grundke-Iqbal, and K. Iqbal Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules Arch. Biochem. Biophys. 357 1998 299 309
    • (1998) Arch. Biochem. Biophys. , vol.357 , pp. 299-309
    • Sengupta, A.1    Kabat, J.2    Novak, M.3    Wu, Q.4    Grundke-Iqbal, I.5    Iqbal, K.6
  • 44
    • 0029870602 scopus 로고    scopus 로고
    • Differential phosphorylation of human tau isoforms containing three repeats by several protein kinases
    • T.J. Singh, I. Grundke-Iqbal, and K. Iqbal Differential phosphorylation of human tau isoforms containing three repeats by several protein kinases Arch. Biochem. Biophys. 328 1996 43 50
    • (1996) Arch. Biochem. Biophys. , vol.328 , pp. 43-50
    • Singh, T.J.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 45
    • 0031727983 scopus 로고    scopus 로고
    • Ser262 in human recombinant tau protein is a markedly more favorable site for phosphorylation by CaMKII than PKA or PhK
    • J.J Sironi, S.H. Yen, J.A. Gondal, Q. Wu, I. Grundke-Iqbal, and K. Iqbal Ser262 in human recombinant tau protein is a markedly more favorable site for phosphorylation by CaMKII than PKA or PhK FEBS Lett. 436 1998 471 475
    • (1998) FEBS Lett. , vol.436 , pp. 471-475
    • Sironi, J.J.1    Yen, S.H.2    Gondal, J.A.3    Wu, Q.4    Grundke-Iqbal, I.5    Iqbal, K.6
  • 46
    • 0018380690 scopus 로고
    • Decoration and stabilization of intact, smooth-walled microtubules with microtubule-associate proteins
    • R.D. Sloboda, and J.L. Rosenbaum Decoration and stabilization of intact, smooth-walled microtubules with microtubule-associate proteins Biochemistry 18 1979 48 55
    • (1979) Biochemistry , vol.18 , pp. 48-55
    • Sloboda, R.D.1    Rosenbaum, J.L.2
  • 48
    • 0032540459 scopus 로고    scopus 로고
    • The regulation of phosphorylation of Ï., in SY5Y neuroblastoma cells: The role of protein phosphatases
    • T. Tanaka, J. Zhong, K. Iqbal, E. Trenkner, and I. Grundke-Iqbal The regulation of phosphorylation of Ï., in SY5Y neuroblastoma cells: the role of protein phosphatases FEBS Lett. 426 1998 248 254
    • (1998) FEBS Lett. , vol.426 , pp. 248-254
    • Tanaka, T.1    Zhong, J.2    Iqbal, K.3    Trenkner, E.4    Grundke-Iqbal, I.5
  • 49
    • 0033169066 scopus 로고    scopus 로고
    • Dynamic regulation of expression and phosphorylation of tau by fibroblast growth factor-2 in neural progenitor cells from adult rat hippocampus
    • Y. Tatebayashi, K. Iqbal, and I. Grundke-Iqbal Dynamic regulation of expression and phosphorylation of tau by fibroblast growth factor-2 in neural progenitor cells from adult rat hippocampus J. Neurosci. 19 1999 5245 5254
    • (1999) J. Neurosci. , vol.19 , pp. 5245-5254
    • Tatebayashi, Y.1    Iqbal, K.2    Grundke-Iqbal, I.3
  • 50
    • 0025201210 scopus 로고
    • The role of microtubule-associated proteins in brain morphogenesis: A review
    • R.A. Tucker The role of microtubule-associated proteins in brain morphogenesis: a review Brain Res. Rev. 15 1990 101 120
    • (1990) Brain Res. Rev. , vol.15 , pp. 101-120
    • Tucker, R.A.1
  • 51
    • 0032566623 scopus 로고    scopus 로고
    • Ï., is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase
    • J.Z. Wang, Q. Wu, A. Smith, I. Grundke-Iqbal, and K. Iqbal Ï., is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase FEBS Lett. 436 1998 28 34
    • (1998) FEBS Lett. , vol.436 , pp. 28-34
    • Wang, J.Z.1    Wu, Q.2    Smith, A.3    Grundke-Iqbal, I.4    Iqbal, K.5
  • 52
    • 0032782439 scopus 로고    scopus 로고
    • Hyperphosphorylated tau in SY5Y cells similarities and dissimilarities to abnormally hyperphosphorylated tau from Alzheimer disease brain
    • J. Zhong, K. Iqbal, and I. Grundke-Iqbal Hyperphosphorylated tau in SY5Y cells similarities and dissimilarities to abnormally hyperphosphorylated tau from Alzheimer disease brain FEBS Lett. 453 1999 224 228
    • (1999) FEBS Lett. , vol.453 , pp. 224-228
    • Zhong, J.1    Iqbal, K.2    Grundke-Iqbal, I.3


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