Ovarian function and morphology after deletion of the DARPP-32 gene in mice

Experimental and Clinical Endocrinology and Diabetes

Volumn 112, Issue 8, 2004, Pages 451-457

  Mayerhofer, Artur ^a   Fritz, S ^a   Mani, S ^b   Kumar, T Rajendra ^b   Thalhammer, A ^a   Ingrassia, P ^c   Fienberg, A A ^c   Greengard, P ^c  

^a UNIVERSITY OF MUNICH   (Germany)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Corpus luteum; Follicle; Hormone; Neurotransmitter; Signal transduction

Indexed keywords

PHOSPHOPROTEIN DARPP 32; PHOSPHOPROTEIN PHOSPHATASE 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; CORPUS LUTEUM; DARPP 32 GENE; FEMALE; GENE; GENE DELETION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OVARY FOLLICLE DEVELOPMENT; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALS; DOPAMINE AND CAMP-REGULATED PHOSPHOPROTEIN 32; FEMALE; FOLLICULAR ATRESIA; GENE DELETION; HYPERTROPHY; MICE; NERVE TISSUE PROTEINS; OVARIAN CYSTS; OVARY; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEINS; PROGESTERONE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 4744340831     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-821205     Document Type: Conference Paper

References (41)

1. Bulling A, Berg FD, Berg U, Duffy DM, Stouffer RL, Ojeda SR, Gratzl M, Mayerhofer A. Identification of an ovarian voltage-activated Na+ channel type: Hints to involvement in luteolysis. Mol Endo 2000; 14: 1064-1074
2. Cho BN, McMullen ML, Pei L, Yates CJ, Mayo KE. Reproductive deficiencies in transgenic mice expressing the rat inhibin alpha-subunit gene. Endocrinology 2000; 142: 4994-5004
3. Conneely OM, Mulac-Jericevic B, Lydon JP, De Mayo FJ. Reproductive functions of the progesterone receptor isoforms: lessons from knock-out mice. Mol Cell Endocrinol 2001; 179: 97-103
4. Dissen GA, Romero C, Hirshfield AN, Ojeda SR. Nerve growth factor is required for early follicular development in the mammalian ovary. Endocrinology 2001; 142: 2078-2086
5. Dong J, Albertini DF, Nishimori K, Kumar TR, Lu N, Matzuk MM. Growth differentiation factor-9 is required during early ovarian folliculogenesis. Nature 1996; 383: 531-535
6. Duleba AJ, Pehlivan T, Carbone R, Spaczynski RZ. Activin stimulates proliferation of rat ovarian thecal-interstitial cells. Biol Reprod 2001; 65: 704-709
7. El-Hefnawy T, Zeleznik AJ. Synergism between FSH and activin in the regulation of proliferating cell nuclear antigen (PCNA) and cyclin D2 expression in rat granulosa cells. Endocrinology 2001; 142: 4357-4362
8. Eppig JJ, Wigglesworth K, Pendola FL. The mammalian oocyte orchestrates the rate of ovarian follicular development. Proc Natl Acad Sci (USA) 2002; 99: 2890-2894
9. Fienberg AA, Hiroi N, Mermelstein PG, Song W, Snyder GL, Nishi A, Cheramy A, O'Callaghan JP, Miller DB, Cole DG, Corbett R, Haile CN, Cooper DC, Onn SP, Grace AA, Ouimet CC, White FJ, Hyman SE, Surmeier DJ, Girault J, Nestler EJ, Greengard P. DARPP-32: regulator of the efficacy of dopaminergic neurotransmission. Science 1998; 281: 838-842
10. Findlay JK, Drummond AE, Dyson M, Baillie AJ, Robertson DM, Ethier J. Production and actions of inhibin and activin during folliculogenesis in the rat. Mol Cell Endocrinol 2001; 180: 139-144
11. Flores-Hernandez J, Hernandez S, Snyder GL, Yan Z, Fienberg AA, Moss SJ, Greengard P, Surmeier DJ. D(1) dopamine receptor activation reduces GABA(A) receptor currents in neostriatal neurons through a PKA/DARPP-32/PP1 signaling cascade. J Neurophysiol 2000; 83: 2996-3004
12. Fritz S, Kunz L, Grünert R, Heiss C, Dimitrijevic N, Mayerhofer A. Muscarinic receptors in human luteinized granulosa cells: Activation blocks gap junctions and induces the transcription factor egr-1. J Clin Endocrinol Metab 2002; 87: 1362-1367
13. Greengard P, Allen PB, Nairn AC. Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade. Neuron 1999; 23: 435-447
14. Greengard P. The neurobiology of slow synaptic transmission. Science 2001; 294: 1024-1030
15. Heyser CJ, Fienberg AA, Greengard P, Gold LH. DARPP-32 knockout mice exhibit impaired reversal learning in a discriminated operant task. Brain Res 2000; 867: 122-130
16. Hiroi N, Fienberg AA, Haile CN, Alburges M, Hanson GR, Greengard P, Nestler EJ. Neuronal and behavioural abnormalities in striatal function in DARPP-32-mutant mice. Eur J Neurosci 1999; 11: 1114-1118
17. Kumar TR, Wang Y, Lu N, Matzuk, MM. Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility. Nat Genet 1997; 115: 201-204
18. Lara HE, Porcile A, Espinoza J, Romero C, Luza SM, Fuhrer J, Miranda C, Roblero L. Release of norepinephrine from human ovary: coupling to steroidogenic response. Endocrine 2001; 15: 187-192
19. Lydon JP, DeMayo FJ, Funk CR, Mani SK, Hughes AR, Montgomery CA Jr, Shyamala G, Conneely OM, O'Malley BW. Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev 1995; 9: 2266-2278
20. Mani SK, Allen JM, Clark JH, Blaustein JD, O'Malley BW. Convergent pathways for steroid hormone- and neurotransmitter-induced rat sexual behavior. Science 1994; 265: 1246-1249
21. Mani SK, Fienberg AA, O'Callaghan JP, Snyder GL, Allen PB, Dash PK, Moore AN, Mitchell AJ, Bibb J, Greengard P, O'Malley BW. Requirement for DARPP-32 in progesterone-facilitated sexual receptivity in female rats and mice. Science 2000; 287: 1053-1056
22. Mayerhofer A, Dissen GA, Parrott JA, Hill DF, Mayerhofer D, Garfield RE, Costa ME, Skinner MK, Ojeda SR. Involvement of nerve growth factor in the ovulatory cascade: trkA receptor activation inhibits gap junctional communication between thecal cells. Endocrinology 1996; 137: 5662-5670
23. Mayerhofer A, Dissen GA, Costa ME, Ojeda SR. A role for neurotransmitters in early follicular development: induction of functional follicle-stimulating hormone receptors in newly formed follicles of the rat ovary. Endocrinology 1997; 138: 3320-3329
24. Mayerhofer A, Smith GD, Danilchik M, Levine JE, Wolf, DP, Dissen GA, Ojeda SR. Oocytes are a source of catecholamines in the primate ovary: Evidence for a novel cell-cell regulatory loop in the ovary. Proc Natl Acad Sci (USA) 1998; 95: 10990-10995
25. Mayerhofer A, Frungieri MB, Bulling A, Fritz S. Sources and function of neuronal signalling molecules in the gonads. Medicina (B Aires) 1999a; 59 (5 Pt 2): 542-545
26. Mayerhofer A, Hemmings HC Jr, Greengard P, Boddien S, Berg U, Brucker C. Functional dopamine-1 receptor (D1-R) and DARPP-32 are expressed in human ovary and granulosa luteal cells in vitro. J Clin Endo Metab 1999b; 84: 257-264
27. Mayerhofer A, Fritz S, Grünert R, Sanders SL, Duffy DM, Ojeda SR, Stouffer RL. D1-Receptor, DARPP-32, and PP-1 in the primate corpus luteum and luteinized granulosa cells: Evidence for phosphorylation of DARPP-32 by dopamine and human chorionic gonadotropin. J Clin Endocrinol Metab 2000; 85: 4750-4757
28. Ojeda SR, Mayerhofer A, Dissen GA, Hill DF, Smith GD, Wolf DP, Dees WL, Skinner MK. Ovarian development is influenced by a neuroendocrinotrophic regulatory complex. In: Filicori M, Flamigni C (Eds). The Ovary: Regulation, Dysfunction, and Treatment. Amsterdam: Elsevier, 1996: 589-608
29. Park JI, Kim WJ, Wang L, Park HJ, Lee J, Park JH, Kwon HB, Tsafriri A, Chun Y. Involvement of progesterone in gonadotrophin-induced pituitary adenylate cyclase-activating polypeptide gene expression in pre-ovulatory follicles of rat ovary. Mol Hum Reprod 2000; 6: 238-245
30. Park J-Y, Su Y-Q, Ariga M, Law E, Jin S-L, Conti M. EGF-like growth factors as mediators of LH action in the ovulatory follicle. Science 2004; 303: 682-684 Epub 2004 Jan 15
31. Power RF, Mani SK, Codina J, Conneely OM, O'Malley BW. Dopaminergic and ligand-independent activation of steroid hormone receptors. Science 1991; 25: 1636-1639
32. Richards JS. Hormonal control of gene expression in the ovary. Endocr Rev 1994; 15: 725-751
33. Richards JS. Perspective: The ovarian follicle - a perspective in 2001. Endocrinology 2001a; 142: 2184-2193
34. Richards JS. New signaling pathways for hormones and cyclic adenosine 3′,5′-monophosphate action in endocrine cells. Mol Endo 2001b; 15: 209-218
35. Risinger FO, Freeman PA, Greengard P, Fienberg AA. Motivational effects of ethanol in DARPP-32 knock-out mice. J Neurosci 2001; 21: 340-348
36. Robker RL, Russell DL, Espey LL, Lydon JP, O'Malley BW, Richards JS. Progesterone-regulated genes in the ovulation process: ADAMTS-1 and cathepsin L proteases. Proc Natl Acad Sci (USA) 2000; 97: 4689-4694
37. Rose UM, Hanssen RG, Kloosterboer HJ. Development and characterization of an in vitro ovulation model using mouse ovarian follicles. Biol Reprod 1999; 61: 503-511
38. Snyder GL, Fienberg AA, Huganir RL, Greengard P. A dopamine/D1 receptor/protein kinase A/dopamine- and cAMP-regulated phosphoprotein (Mr 32 kDa)/protein phosphatase-1 pathway regulates dephosphorylation of the NMDA receptor. J Neurosci 1998; 18: 10 297-10 303
39. Sommersberg B, Bulling A, Salzer U, Fröhlich U, Garfield RE, Amsterdam A, Mayerhofer A. Gap junction communication and connexin 43 gene expression in a rat granulosa cell line: regulation by follicle-stimulating hormone. Biol Reprod 2000; 63: 1661-1668
40. Svenningsson P, Fienberg AA, Allen PB, Moine CL, Lindskog M, Fisone G, Greengard P, Fredholm BB. Dopamine D(1) receptor-induced gene transcription is modulated by DARPP-32. J Neurochem 2000; 75: 248-257
41. Ying Y, Liu X-M, Marble A, Lawson KA, Zhao G-Q. Requirement of Bmp8 b for the generation of primordial germ cells in the mouse. Mol Endo 2000; 14: 1053-1063