(d)-2-tert-Butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid: Synthesis and incorporation into the growth hormone secretagogues

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 14, 2008, Pages 4072-4074

  Li, Jun ^a   Chen, Stephanie Y ^a   Murphy, Brian J ^a   Flynn, Neil ^a   Seethala, Ramakrishna ^a   Slusarchyk, Dorothy ^a   Yan, Mujing ^a   Sleph, Paul ^a   Zhang, Hongjian ^a   Humphreys, William G ^a   Ewing, William R ^a   Robl, Jeffrey A ^a   Gordon, David ^a   Tino, Joseph A ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Growth hormone secretagogue

Indexed keywords

2 TERT BUTOXYCARBONYLAMINO 5,5 DIFLUORO 5 PHENYLPENTANOIC ACID DERIVATIVE; GROWTH HORMONE; GROWTH HORMONE SECRETAGOGUE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH HORMONE RELEASE; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CARBAMATES; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; GROWTH HORMONE; INDOLES; MODELS, CHEMICAL; PENTANOIC ACIDS; PEPTIDE HORMONES; RATS; SPIRO COMPOUNDS; STEREOISOMERISM; TETRAZOLES;

RATTUS;

EID: 47349115764     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.05.100     Document Type: Article

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