Similarities and differences between insulin and IGF-I: Structures, receptors, and signalling pathways

Archives of Physiology and Biochemistry

Volumn 114, Issue 1, 2008, Pages 17-22

  Werner, Haim ^a   Weinstein, Doron ^a   Bentov, Itay ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Insulin; Insulin receptor; Insulin like growth factor (IGF); Signalling

Indexed keywords

INSULIN; INSULIN RECEPTOR; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

ANIMAL; CHEMISTRY; COMPARATIVE STUDY; GENETICS; GENOMICS; HUMAN; METABOLISM; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; GENOMICS; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

EID: 47349112424     PISSN: 13813455     EISSN: 17444160     Source Type: Journal    
DOI: 10.1080/13813450801900694     Document Type: Review

References (53)

1. Abbott AM, Bueno R, Pedrini MT, Murray JM, Smith RJ. 1992. Insulin-like growth factor I receptor gene structure. J Biol Chem 267:10759-63.
2. Accili D, Drago J, Lee EJ, Johnson MD, Cool MH, Salvatore P, Asico LD, Jose PA, Taylor SI, Westphal H. 1996. Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nature Genetics 12:106-9.
3. Alarcon C, Morales AV, Pimentel B, Serna J, de Pablo F. 1998. (Pro)insulin and insulin-like growth factor I complementary expression and roles in early development. Comp Biochem Physiol B Biochem Mol Biol 121:13-17.
4. Baker J, Liu J-P, Robertson EJ, Efstratiadis A. 1993. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75:73-82.
5. Baxter RC. 2000. Insulin-like growth factor-binding proteins: interactions with IGFs and intrinsic bioactivities. Am J Physiol 278:967-76.
6. Bayne ML, Applebaum J, Underwood D, Chicchi GG, Green BG, Hayes NS, Cascieri MA. 1989. The C region of the human insulin-like growth factor (IGF) I is required for high affinity binding to the type 1 IGF receptor. J Biol Chem 264:11004-11.
7. Bendall SC, Stewart MH, Menendez P, George D, Vijayaragavan K, Werbowetski-Ogilvie T, Ramos-Mejia V, Rouleau A, Yang J, Bosse M, et al. 2007. IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro. Nature 448:1015-23.
8. Bentov I, Werner H. 2004. IGF, IGF receptor and overgrowth syndromes. Pediatr Endocrinol Rev 1:352-60.
9. Bentov I, Werner H. 2006. Insulin-like growth factor-I. In: Kastin A, editor. Handbook of Biologically Active Peptides. San Diego: Elsevier Press; pp 1385-92.
10. Christofori G, Naik P, Hanahan D. 1994. A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis. Nature 369:414-18.
11. DeChiara TM, Efstratiadis A, Robertson EJ. 1990. A growthdeficiency phenotype in heterozygous mice carrying an insulinlike growth factor II gene disrupted by targeting. Nature 345:78-80.
12. Denley A, Brierley GV, Carroll JM, Lindenberg A, Booker GW, Cosgrove L, Wallace JC, Forbes BE, Roberts Jr CT. 2006. Differential activation of insulin receptor isoforms by insulin-like growth factors is determined by the C domain. Endocrinology 147:1029-36.
13. Dupont J, LeRoith D. 2001. Insulin and insulin-like growth factor-I receptors: similarities and differences in signal transduction. Hormone Research 55(Suppl. 2):22-6.
14. Ebina Y, Ellis L, Jarnagin K, Edery M, Graf L, Clauser E, Qu J, Masiarz F, Kan YW, Goldfine ID, Roth RA, Rutter WJ. 1985. The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling. Cell 40:747-58.
15. Florini JR, Ewton DZ. 1990. Highly specific inhibition of IGF-I-stimulated differentiation by an antisense oligodeoxyribonucleotide to myogenin mRNA. No effects on other actions of IGF-I. J Biol Chem 265:13435-7.
16. Frasca F, Pandini G, Scalia R, Sciacca L, Mineo R, Constantino A, Goldfine ID, Belfiore A, Vigneri R. 1999. Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Mol Cell Biol 19:3278-88.
17. Grill CJ, Cohick WS. 2000. Insulin-like growth factor binding protein-3 mediates IGF-I action in a bovine mammary epithelial cell line independent of an IGF interaction. J Cell Physiol 183:273-83.
18. Guler HP, Zapf J, Froesch ER. 1987. Short-term metabolic effects of recombinant human insulin-like growth factor I in healthy adults. New England J Med 317:137-40.
19. Holly J, Perks C. 2006. The role of insulin-like growth factor binding proteins. Neuroendocrinology 83:154-60.
20. Jacobs S, Kull FC Jr, Cuatrecasas P. 1983. Monensin blocks the maturation of receptors for insulin and somatomedin C: identification of receptor precursors. Proc Natl Acad Sci USA 80:1228-32.
21. Kjeldsen T, Andersen AS, Wiberg FC, Rasmussen JS, Schaffer L, Balschmidt P, Moller KB, Moller NPH. 1991. The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site. Proc Natl Acad Sci USA 88:4404-8.
22. Klammt J, Garten A, Barnikol-Oettler A, Beck-Sickinger AG, Kiess W. 2005. Comparative analysis of the signalling capabilities of the insulin receptor-related receptor. Biochem Biophys Res Comm 327:557-64.
23. Laviola L, Giorgino F, Chow JC, Baquero JA, Hansen H, Ooi J, Zhu J, Riedel H, Smith RJ. 1997. The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts. J Biol Chem 99:830-7.
24. Leboulleux S, Gaston V, Boulle N, Le Bouc Y, Gicquel C. 2001. Loss of heterozygosity at the mannose-6-phosphate/insulin-like growth factor 2 receptor locus: a frequent but late event in adrenocortical tumorigenesis. Eur J Endocrinol 144:163-8.
25. LeRoith D, Bondy C, Yakar S, Liu J-L, Butler A. 2001. The Somatomedin hypothesis: 2001. Endocrine Rev 22:53-74.
26. LeRoith D, Werner H, Beitner-Johnson D, Roberts CT Jr. 1995. Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocrine Rev 16:143-63.
27. Liu J-P, Baker J, Perkins AS, Robertson EJ, Estratiadis A. 1993. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75:59-72.
28. Lu K, Campisi J. 1992. Ras proteins are essential and selective for the action of insulin-like growth factor 1 late in the G1 phase of the cell cycle in BALB/c murine fibroblasts. Proc Natl Acad Sci USA 89:3889-93.
29. Macaulay VM. 1992. Insulin-like growth factors and cancer. Br J Cancer 65:311-20.
30. Mastick CC, Brady MJ, Printen JA, Ribon V, Saltiel AR. 1998. Spatial determinants of specificity in insulin action. Mol Cell Biochem 182:65-71.
31. MorganDO, Edman JC, Standring DN, Fried VA, SmithMC, Roth RA, Rutter WJ. 1987. Insulin-like growth factor II receptor as a multifunctional binding protein. Nature 329:301-7.
32. Morrione A, Valentinis B, Xu S, Yumet G, Louvi A, Efstratiadis A, Baserga R. 1997. Insulin-like growth factor II stimulates cell proliferation through the insulin receptor. Proc Natl Acad Sci USA 94:3777-82.
33. Moschos SJ, Mantzoros CS. 2002. The role of the IGF system in cancer: from basic to clinical studies and clinical applications. Oncology 63:317-32.
34. Najjar SM, Blakesley VA, Li Calzi S, Kato H, LeRoith D, Choice CV. 1997. Differential phosphorylation of pp120 by insulin and insulin-like growth factor I receptors: role for the C-terminal domain of the beta-subunit. Biochemistry 36:6827-34.
35. Nakae J, Kido Y, Accili D. 2001. Distinct and overlapping functions of insulin and IGF-I receptors. Endocrine Rev 22:818-35.
36. Powell-Braxton L, Hollingshead P, Warburton C, Dowd M, Pitts-Meek S, Dalton D, Gillett N, Stewart TA. 1993. IGF-I is required for normal embryonic growth in mice. Genes and Development 7:2609-17.
37. Rechler M, Zapf J, Nissley S, Froesch E, Moses A, Podskalny J, Schilling E, Humbel R. 1980. Interactions of insulin-like growth factors I and II and multiplication-stimulating activity with receptors and serum carrier proteins. Endocrinology 107:1451-8.
38. Resnicoff M, Abraham D, Yutanawiboonchai W, Rotman HL, Kajstura J, Rubin R, Zoltick P, Baserga R. 1995. The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo. Cancer Res 55:2463-9.
39. Rinderknecht E, Humbel RE. 1978. The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin. J Biol Chem 253:2769-76.
40. Rosenfeld RG. 2005. The IGF system: new developments relevant to pediatric practice. Endocr Dev 9:1-10.
41. Rubini M, Hongo A, D'Ambrosio C, Baserga R. 1997. The IGF-I receptor in mitogenesis and transformation of mouse embryo cells: role of receptor number. Exp Cell Res 230:284-92.
42. Salmon WD, Daughaday WH. 1957. A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med 49:825-36.
43. Seino S, Seino M, Nishi S, Bell GI. 1989. Structure of the human insulin receptor gene and characterization of its promoter. Proc Natl Acad Sci USA 86:114-18.
44. Sell C, Baserga R, Rubin R. 1995. Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis. Cancer Res 55:303-6.
45. Shier P, Watt VM. 1989. Primary structure of a putative receptor for a ligand of the insulin family. J Biol Chem 264:14605-8.
46. Tollefsen SE, Thompson K. 1988. The structural basis for insulinlike growth factor I receptor high affinity binding. J Biol Chem 263:16267-73.
47. Ullrich A, Bell JR, Chen EY, Herrera R, Petruzzeli LM, Dull TJ, Gray A, Coussens L, Liao Y-C, Tsubokawa M, et al. 1985. Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature 313:756-61.
48. Ullrich A, Gray A, Tam AW, Yang-Feng T, Tsubowka M, Collins C, Henzel W, Lebon T, Kathuria S, Chen F, et al. 1986. Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests determinants that define functional specificity. EMBO J 5:2503-12.
49. Werner H, LeRoith D. 2000. New concepts in regulation and function of the insulin-like growth factors: implications for understanding normal growth and neoplasia. Cell Mol Life Sci 57:932-42.
50. Werner H, Woloschak M, Stannard B, Shen-Orr Z, Roberts Jr CT, LeRoith D. 1991. Insulin-like growth factor receptor: Molecular biology, heterogeneity, and regulation. In: LeRoith D, editor. Insulin-like Growth Factors: Molecular and Cellular Aspects. Boca Raton, FL: CRC Press; pp 17-47.
51. Yakar S, Liu JL, Stannard B, Butler A, Accili D, Sauer B, LeRoith D. 1999. Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc Natl Acad Sci USA 96:7324-9.
52. Yakar S, Sun H, Zhao H, Pennisi P, Toyoshima Y, Setser J, Stannard B, Scavo L, LeRoith D. 2005. Metabolic effects of IGF-I deficiency: lessons from mouse models. Pediatr Endocrinol Rev 3:11-19.
53. Zapf A, Hsu D, Olefsky JM. 1994. Comparison of the intracellular itineraries of insulin-like growth factor-I and insulin and their receptors in Rat-1 fibroblasts. Endocrinology 134:2445-52.