Dynamics of glyphosate-induced conformational changes of Mycobacterium tuberculosis 5-enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) determined by hydrogen-deuterium exchange and electrospray mass spectrometry

Biochemistry

Volumn 47, Issue 28, 2008, Pages 7509-7522

  Marques, Maurício R ^a   Vaso, Alessandra ^a   Neto, João Ruggiero ^b   Fossey, Marcelo A ^b   Oliveira, Jaim S ^c   Basso, Luiz A ^c   Dos Santos, Diógenes S ^d   De Azevedo Jr , Walter F ^d   Palma, Mario S ^a  

^a Institute of Biosciences   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^d PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDS; AMINES; AMINO ACIDS; AROMATIC COMPOUNDS; BINDING ENERGY; BINDING SITES; BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; CADMIUM COMPOUNDS; CONFORMATIONS; DEUTERIUM; DICHROISM; ENZYMES; FOOD ADDITIVES; HERBICIDES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEN; MASS SPECTROMETERS; MASS SPECTROMETRY; NONMETALS; OPTICAL PROPERTIES; ORGANIC ACIDS; SOLVENTS; SPECTROMETERS; SPECTROMETRY; SPECTRUM ANALYSIS; SUBSTRATES; WEIGHT CONTROL;

AMERICAN CHEMICAL SOCIETY (ACS); AROMATIC AMINO ACIDS; CIRCULAR DICHROISM (DC); CONFORMATIONAL CHANGES; ELECTROSPRAY IONIZATION MASS SPECTROMETRY (ESI_MS); ELECTROSPRAY MASS SPECTROMETRY (ESI MS); ENZYME CONFORMATIONS; GLYPHOSATE (N PHOSPHONOMETHYL GLYCINE); H/D EXCHANGE; HYDROGEN-DEUTERIUM EXCHANGE (HDX); MYCOBACTERIUM TUBERCULOSIS (MTAHPC); OPEN CONFORMATION; PHOSPHOENOL PYRUVATE (PEP); SECONDARY STRUCTURES; SHIKIMATE; SHIKIMATE PATHWAY; SUBSTRATE BINDING (SBD); SYNERGISTIC EFFECTS (SE); SYNTHASE; THREE-DIMENSIONAL (3D) STRUCTURING; TO MANY;

ENZYME INHIBITION;

3 PHOSPHOSHIKIMATE 1 CARBOXYVINYLTRANSFERASE; AROMATIC AMINO ACID; GLYPHOSATE; PHOSPHOENOLPYRUVATE; SHIKIMIC ACID;

ALPHA HELIX; AMINO ACID SYNTHESIS; ARTICLE; BETA SHEET; BINDING SITE; CATALYSIS; CIRCULAR DICHROISM; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; DEUTERIUM HYDROGEN EXCHANGE; ELECTROSPRAY MASS SPECTROMETRY; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; HYDRATION; HYDROGEN BOND; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE;

3-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE; APOENZYMES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; DEUTERIUM; GLYCINE; HYDROGEN; KINETICS; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; PEPTIDE MAPPING; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

MYCOBACTERIUM TUBERCULOSIS;

EID: 47249154017     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800134y     Document Type: Article

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