Acute generalised exanthematous pustulosis and toxic epidermal necrolysis induced by carbamazepine

Singapore Medical Journal

Volumn 49, Issue 6, 2008, Pages 507-510

  Goh, T K ^a,c   Pang, S M ^a   Thirumoorthy, T ^a   Goh, S G N ^b  

^a SINGAPORE GENERAL HOSPITAL   (Singapore)

^b Department of Pathology ^*

^c CHANGI GENERAL HOSPITAL   (Singapore)

Author keywords

Acute generalised exanthematous pustulosis; Carbamazepine; Stevens Johnson syndrome toxic epidermal necrolysis overlap

Indexed keywords

CARBAMAZEPINE; DOXYCYCLINE; ERYTHROMYCIN; HYDROCORTISONE; IMMUNOGLOBULIN; VALPROIC ACID;

ADULT; ARTICLE; CASE REPORT; DRUG HYPERSENSITIVITY; DRUG WITHDRAWAL; EPILEPSY; FEMALE; HISTOPATHOLOGY; HUMAN; RASH; STEVENS JOHNSON SYNDROME; TOXIC EPIDERMAL NECROLYSIS;

ADULT; ANTICONVULSANTS; CARBAMAZEPINE; DRUG ERUPTIONS; EPIDERMAL NECROLYSIS, TOXIC; EXANTHEMA; FEMALE; HUMANS; SKIN DISEASES, VESICULOBULLOUS;

EID: 47249141698     PISSN: 00375675     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Chave TA, Mortimer NJ, Sladden MJ, Hall AP, Hutchinson PE. Toxic epidermal necrolysis: current evidence, practical management and future directions. Br J Dermatol 2005; 153:241-53.
2. Paquet P, Piérard GE, Quatresooz P. Novel treatments for drug-induced toxic epidermal necrolysis (Lyell's syndrome). Int Arch Allergy Immunol 2005; 136:205-16.
3. Roujeau JC, Bioulac-Sage P, Bourseau C, et al. Acute generalized exanthematous pustulosis. Analysis of 63 cases. Arch Dermatol 1991;12:1333-8.
4. Sidoroff A, Halevy S, Bavinck JNB, Vaillant L, Roujeau JC. Acute generalized exanthematous pustulosis (AGEP)-a clinical reaction pattern. J Cutan Pathol 2001; 28:113-9.
5. Wolkenstein P, Chosidow O, Fléchet ML, et al. Patch testing in severe cutaneous adverse drug reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis. Contact Dermatitis 1996; 35:234-6.
6. Mashiah J, Brenner S. A systemic reaction to patch testing for the evaluation of acute generalized exanthematous pustulosis. Arch Dermatol 2003; 139:1181-3.
7. Hausermann P, Scherer K, Weber M, Bircher AJ. Ciprofloxacin-induced acute generalized exanthematous pustulosis mimicking bullous drug eruption confirmed by a positive patch test. Dermatology 2005; 211:277-80.
8. Schmid S, Kuechler PC, Britschgi M, et al. Acute generalized exanthematous pustulosis: role of cytotoxic T cells in pustule formation. Am J Pathol 2002; 161: 2079-86.
9. Britschgi M, Steiner UC, Schmid S, et al. T-cell involvement in drug-induced acute generalized exanthematous pustulosis. J Clin Invest 2001; 107:1433-41.
10. Schaerli P, Britschgi M, Keller M, et al. Characterization of human T cells that regulate neutrophilic skin inflammation. J Immunol 2004;173:2151-8.
11. Cohen AD, Cagnano E, Halevy S. Acute generalized exanthematous pustulosis mimicking toxic epidermal necrolysis. Int J Dermatol 2001; 40:458-61.
12. Byerly FL, Nelson KC, Granko RP, Morell DS, Cairns BA. Valdecoxib-associated acute generalized exanthematous pustulosis. Burns 2005; 31:383-7.
13. Lin JH, Sheu HM, Lee JY. Acute generalized exanthematous pustulosis with erythema multiforme-like lesions. Eur J Dermatol 2002; 12:475-8.
14. Sneddon IB. Subcorneal pustules in erythema multiforme. Br J Dermatol 1973; 88:605-7.
15. Commens CA, Fischer GO. Toxic pustuloderma following carbamazepine therapy. Arch Dermatol 1988; 124:178-9.