Acute generalized exanthematous pustulosis: Role of cytotoxic T cells in pustule formation

American Journal of Pathology

Volumn 161, Issue 6, 2002, Pages 2079-2086

  Schmid, Simone ^a   Kuechler, Petra C ^a   Britschgi, Markus ^a   Steiner, Urs C ^a   Yawalkar, Nikhil ^a   Limat, Alain ^c   Baltensperger, Kurt ^b   Braathen, Lasse ^a   Pichler, Werner J ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c Modex Therapeutiques   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; CD4 ANTIGEN; CD8 ANTIGEN; CELECOXIB; CLAVULANIC ACID; FAS ANTIGEN; FAS LIGAND; GRANZYME B; INTERLEUKIN 8; PERFORIN; SULFAMETHOXAZOLE;

ADULT; ARTICLE; CELL ASSAY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE ACTIVATION; MALE; PATCH TEST; PATHOGENESIS; PRIORITY JOURNAL; PUNCH BIOPSY; PUSTULE; PUSTULOSIS;

EID: 0036899105     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64486-0     Document Type: Article

References (25)

1. Britschgi M, Steiner UC, Schmid S, Depta JP, Sentl G, Bircher A, Burkhart C, Yawalkar N, Pichler WJ: T-cell involvement in drug-induced acute generalized exanthematous pustulosis. J Clin Invest 2001, 107:1433-1441
2. Roujeau JC: Neutrophilic drug eruptions. Clin Dermatol 2000, 18:331-337
3. Roujeau J, Bioulac-Sage P, Bourseau C: Acute generalized exanthematous pustulosis: Analysis of 63 cases. Arch Dermatol 1991, 127:1333-1338
4. Schnyder B, Frutig K, Mauri-Hellweg D, Limat A, Yawalkar N, Pichler WJ: T-cell-mediated cytotoxicity against keratinocytes in sulfamethoxazol-induced skin reaction. Clin Exp Allergy 1998, 28:1412-1417
5. Zlotnik A, Yoshie O: Chemokines: A new classification system and their role in immunity. Immunity 2000, 12:121-127
6. Hari Y, Frutig-Schnyder K, Hurni M, Yawalkar N, Zanni MP, Schnyder B, Kappeler A, Von Greyerz S, Braathen LR, Pichler WJ: T cell involvement in cutaneous drug eruptions. Clin Exp Allergy 2001, 31:1398-1408
7. Le Cleach L, Delaire S, Boumsell L, Bagot M, Bourgault-Villada I, Bensussan A, Roujeau JC: Blister fluid T lymphocytes during toxic epidermal necrolysis are functional cytotoxic cells which express human natural killer (NK) inhibitory receptors. Clin Exp Immunol 2000, 119:225-230
8. Sidoroff A, Halevy S, Bavinck JN, Vaillant L, Roujeau JC: Acute generalized exanthematous pustulosis (AGEP) - A clinical reaction pattern. J Cutan Pathol 2001, 28:113-119
9. Wilkinson DS, Fregert S, Magnusson B, Bandmann HJ, Calnan CD, Cronin E, Hjorth N, Maibach HJ, Malalten KE, Meneghini CL, Pirila V: Terminology of contact dermatitis. Acta Derm Venereol 1970, 50:287-292
10. Wyss-Coray T, Gallati H, Pracht I, Limat A, Mauri D, Frutig K, Pichler WJ: Antigen-presenting human T cells and antigen-presenting B cells induce a similar cytokine profile in specific T cell clones. Eur J Immunol 1993, 23:3350-3357
11. Zanni MP, Mauri-Hellweg D, Brander C, Wendland T, Schnyder B, Frei E, von Greyerz S, Bircher A, Pichler WJ: Characterization of lidocaine-specific T cells. J Immunol 1997, 158:1139-1148
12. Wolkenstein P, Chosidow O, Fléchet ML, Robbiola O, Paul M, Dumé L, Revuz J, Roujeau JC: Patch-testing in severe cutaneous adverse drug reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis. Contact Dermatitis 1996, 35:234-236
13. Jan V, Machet L, Gironet N, Martin L, Machet MC, Lorette G, Vaillant L: Acute generalized exanthematous pustulosis induced by dilitiazem: Value of patch testing. Dermatology 1998, 197:274-275
14. Pichler WJ, Yawalkar N, Britschgi M, Depta J, Strasser I, Schmid S, Kuechler P, Naisbitt D: Cellular and molecular pathophysiology of cutaneous drug reactions. Am J Clin Dermatol 2002, 3:229-238
15. Shiohara T, Kokaji T: Polysensitivity in fixed drug eruption. J Am Acad Dermatol 1997, 37:1017-1018
16. Shiohara T, Mizukawa Y, Teraki Y: Pethophysiology of fixed drug eruption: The role of skin-resident T cells. Curr Opin Allergy Clin Immunol 2002, 2:317-323
17. Yawalkar N, Pichler WJ: Pathogenesis of drug-induced exanthema. Int Arch Allergy Immunol 2001, 124:336-338
18. Yawalkar N, Egli F, Hari Y, Nievergelt H, Braathen LR, Pichler WJ: Infiltration of cytotoxic T cells in drug-induced cutaneous eruptions. Clin Exp Allergy 2000, 30:847-855
19. + cytotoxic T lymphocytes in humans. Blood 2000, 95: 2352-2355
20. Posadas SJ, Padial A, Torres MJ, Mayorga C, Leyva L, Sanchez E, Alvarez J, Romano A, Juarez C, Blanca M: Delayed reactions to drugs show levels of perforin, granzyme B, and Fas-L to be related to disease severity. J Allergy Clin Immunol 2002, 109:155-161
21. Robert C, Kupper TS: Inflammatory skin diseases, T cells, and immune surveillance. N Engl J Med 1999, 341:1817-1828
22. Mochizuki M, Morita E, Yamamoto S, Yamana S: Characteristics of T cell lines established from skin lesions of Behcet's disease. J Dermatol Sci 1997, 15:9-13
23. Terui T, Ozawa M, Tagami H: Role of neutrophils in induction of acute inflammation in T-cell-mediated immune dermatosis, psoriasis: A neutrophil-associated inflammation-boosting loop. Exp Dermatol 2000, 9:1-10
24. Mantas C, Direskeneli H, Oz D, Yavuz S, Akoglu T: IL-8 producing cells in patients with Behcet's disease. Clin Exp Rheumatol 2000, 18:249-251
25. Direskeneli H: Behcet's disease: Infectious aetiology, new autoantigens, and HLA-B51. Ann Rheum Dis 2001, 60:996-1002