Experimental hip fracture load can be predicted from plain radiography by combined analysis of trabecular bone structure and bone geometry

Osteoporosis International

Volumn 19, Issue 4, 2008, Pages 547-558

  Pulkkinen, P ^a   Jamsa T ^a,b   Lochmuller E M ^c   Kuhn, V ^c,d   Nieminen, M T ^b   Eckstein, F ^c,e  

^a UNIVERSITY OF OULU   (Finland)

^b OULU UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF MUNICH   (Germany)

^d INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^e PARACELSUS MEDICAL UNIVERSITY   (Austria)

Author keywords

Biomechanics; Bone geometry; Failure load; Osteoporosis; Texture analysis; Trabecular structure

Indexed keywords

AGED; ARTICLE; BIOMECHANICS; BONE DENSITY; BONE STRENGTH; BONE STRUCTURE; CADAVER; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR; FEMUR NECK; FEMUR SHAFT; GEOMETRY; HIP FRACTURE; HIP RADIOGRAPHY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; MALE; PRIORITY JOURNAL; TRABECULAR BONE; COMPUTER ASSISTED TOMOGRAPHY; ECONOMICS; HISTOLOGY; MECHANICAL STRESS; METHODOLOGY; OSTEOPOROSIS; PATHOPHYSIOLOGY; PHYSIOLOGY; STATISTICAL MODEL;

AGED; AGED, 80 AND OVER; BIOMECHANICS; BONE DENSITY; CADAVER; FEMALE; FEMUR; HUMANS; LOGISTIC MODELS; MALE; OSTEOPOROSIS; STRESS, MECHANICAL; TOMOGRAPHY, X-RAY COMPUTED;

EID: 47249102561     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-007-0479-9     Document Type: Article

References (63)

1. Anonymous (1993) Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med 94:646-650
2. Legrand E, Chappard D, Pascaretti C, Duquenne M, Krebs S, Rohmer V, Basle MF, Audran M (2000) Trabecular bone microarchitecture, bone mineral density, and vertebral fractures in male osteoporosis. J Bone Miner Res 15:13-19 (Pubitemid 30026927)
3. Hudelmaier M, Kollstedt A, Lochmüller EM, Kuhn V, Eckstein F, Link TM (2005) Gender differences in trabecular bone architecture of the distal radius assessed with magnetic resonance imaging and implications for mechanical competence. Osteoporos Int 16:1124-1133 (Pubitemid 41225099)
4. Chappard C, Brunet-Imbault B, Lemineur G, Giraudeau B, Basillais A, Harba R, Benhamou CL (2005) Anisotropy changes in post-menopausal osteoporosis: characterization by a new index applied to trabecular bone radiographic images. Osteoporos Int 16:1193-1202 (Pubitemid 41396946)
5. Benhamou CL, Poupon S, Lespessailles E, Loiseau S, Jennane R, Siroux V, Ohley W, Pothuaud L (2001) Fractal analysis of radiographic trabecular bone texture and bone mineral density: two complementary parameters related to osteoporotic fractures. J Bone Miner Res 16:697-704 (Pubitemid 32230598)
6. El-Kaissi S, Pasco JA, Henry MJ, Panahi S, Nicholson JG, Nicholson GC, Kotowicz MA (2005) Femoral neck geometry and hip fracture risk: the Geelong osteoporosis study. Osteoporos Int 16:1299-1303 (Pubitemid 41396960)
7. Partanen J, Jämsä T, Jalovaara P (2001) Influence of the upper femur and pelvic geometry on the risk and type of hip fractures. J Bone Miner Res 16:1540-1546 (Pubitemid 32675206)
8. Pulkkinen P, Partanen J, Jalovaara P, Jämsä T (2004) Combination of bone mineral density and upper femur geometry improves the prediction of hip fracture. Osteoporos Int 15:274-280 (Pubitemid 38543945)
9. Alonso CG, Curiel MD, Carranza FH, Cano RP, Perez AD (2000) Femoral bone mineral density, neck-shaft angle and mean femoral neck width as predictors of hip fracture in men and women. Multicenter Project for Research in Osteoporosis. Osteoporos Int 11:714-720
10. Gnudi S, Ripamonti C, Lisi L, Fini M, Giardino R, Giavaresi G (2002) Proximal femur geometry to detect and distinguish femoral neck fractures from trochanteric fractures in postmenopausal women. Osteoporos Int 13:69-73 (Pubitemid 34157833)
11. Järvinen TL, Sievänen H, Jokihaara J, Einhorn TA (2005) Revival of bone strength: the bottom line. J Bone Miner Res 20:717-720 (Pubitemid 40571627)
12. Anonymous (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. World Health Organ Tech Rep Ser 843:1-129 (Pubitemid 24219162)
13. Schuit SC, van der Klift M, Weel AE, de Laet CE, Burger H, Seeman E, Hofman A, Uitterlinden AG, van Leeuwen JP, Pols HA (2004) Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. Bone 34:195-202 (Pubitemid 38142449)
14. Robbins JA, Schott AM, Garnero P, Delmas PD, Hans D, Meunier PJ (2005) Risk factors for hip fracture in women with high BMD: EPIDOS study. Osteoporos Int 16:149-154 (Pubitemid 40193201)
15. Kanis JA (2002) Diagnosis of osteoporosis and assessment of fracture risk. Lancet 359:1929-1936
16. Marshall D, Johnell O, Wedel H (1996) Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ 312:1254-1259 (Pubitemid 26147662)
17. Nicholson PH, Müller R, Cheng XG, Ruegsegger P, Van Der Perre G, Dequeker J, Boonen S (2001) Quantitative ultrasound and trabecular architecture in the human calcaneus. J Bone Miner Res 16:1886-1892 (Pubitemid 32911496)
18. Njeh CF, Fuerst T, Diessel E, Genant HK (2001) Is quantitative ultrasound dependent on bone structure? A reflection. Osteoporos Int 12:1-15 (Pubitemid 32233653)
19. Bauer JS, Kohlmann S, Eckstein F, Mueller D, Lochmüller EM, Link TM (2006) Structural analysis of trabecular bone of the proximal femur using multislice computed tomography: a comparison with dual X-ray absorptiometry for predicting biomechanical strength in vitro. Calcif Tissue Int 78:78-89
20. Showalter C, Clymer BD, Richmond B, Powell K (2006) Three-dimensional texture analysis of cancellous bone cores evaluated at clinical CT resolutions. Osteoporos Int 17:259-266 (Pubitemid 43053590)
21. Müller R, Van Campenhout H, Van Damme B, Van Der Perre G, Dequeker J, Hildebrand T, Ruegsegger P (1998) Morphometric analysis of human bone biopsies: a quantitative structural comparison of histological sections and micro-computed tomography. Bone 23:59-66 (Pubitemid 28327502)
22. Herlidou S, Grebe R, Grados F, Leuyer N, Fardellone P, Meyer ME (2004) Influence of age and osteoporosis on calcaneus trabecular bone structure: a preliminary in vivo MRI study by quantitative texture analysis. Magn Reson Imaging 22:237-243 (Pubitemid 38326643)
23. Link TM, Majumdar S, Lin JC, Newitt D, Augat P, Ouyang X, Mathur A, Genant HK (1998) A comparative study of trabecular bone properties in the spine and femur using high resolution MRI and CT. J Bone Miner Res 13:122-132 (Pubitemid 28063121)
24. Mueller D, Link TM, Monetti R, Bauer J, Boehm H, Seifert-Klauss V, Rummeny EJ, Morfill GE, Raeth C (2006) The 3D-based scaling index algorithm: a new structure measure to analyze trabecular bone architecture in high-resolution MR images in vivo. Osteoporos Int 17:1483-1493 (Pubitemid 44387483)
25. Lammentausta E, Hakulinen MA, Jurvelin JS, Nieminen MT (2006) Prediction of mechanical properties of trabecular bone using quantitative MRI. Phys Med Biol 51:6187-6198 (Pubitemid 46217658)
26. Vokes TJ, Giger ML, Chinander MR, Karrison TG, Favus MJ, Dixon LB (2006) Radiographic texture analysis of densitometer-generated calcaneus images differentiates postmenopausal women with and without fractures. Osteoporos Int 17:1472-1482
27. Pothuaud L, Lespessailles E, Harba R, Jennane R, Royant V, Eynard E, Benhamou CL (1998) Fractal analysis of trabecular bone texture on radiographs: discriminant value in postmenopausal osteoporosis. Osteoporos Int 8:618-625 (Pubitemid 28566980)
28. Gregory JS, Stewart A, Undrill PE, Reid DM, Aspden RM (2004) Identification of hip fracture patients from radiographs using Fourier analysis of the trabecular structure: a cross-sectional study. BMC Med Imaging 4:4 (Pubitemid 41418168)
29. Lin JC, Grampp S, Link T, Kothari M, Newitt DC, Felsenberg D, Majumdar S (1999) Fractal analysis of proximal femur radiographs: correlation with biomechanical properties and bone mineral density. Osteoporos Int 9:516-524 (Pubitemid 29348567)
30. Chappard D, Chennebault A, Moreau M, Legrand E, Audran M, Basle MF (2001) Texture analysis of X-ray radiographs is a more reliable descriptor of bone loss than mineral content in a rat model of localized disuse induced by the Clostridium botulinum toxin. Bone 28:72-79 (Pubitemid 32112064)
31. Guggenbuhl P, Bodic F, Hamel L, Basle MF, Chappard D (2006) Texture analysis of X-ray radiographs of iliac bone is correlated with bone micro-CT. Osteoporos Int 17:447-454
32. Veenland JF, Grashuis JL, Weinans H, Ding M, Vrooman HA (2002) Suitability of texture features to assess changes in trabecular bone architecture. Pattern Recogn Lett 23:395-403 (Pubitemid 34197119)
33. Singh M, Nagrath AR, Maini PS (1970) Changes in trabecular pattern of the upper end of the femur as an index of osteoporosis. J Bone Joint Surg Am 52:457-467
34. Smyth PP, Adams JE, Whitehouse RW, Taylor CJ (1997) Application of computer texture analysis to the Singh Index. Br J Radiol 70:242-247 (Pubitemid 27129871)
35. Pietka E (1994) Lung segmentation in digital radiographs. J Digit Imaging 7:79-84
36. Petric N, Chan HP, Sahiner B, Helvie MA (1999) Combined adaptive enhancement and region-growing segmentation of breast masses on digital mammograms. Med Phys 26:1642-1654 (Pubitemid 29402275)
37. Paquerault S, Yarusso LM, Papaioannou J, Jiang Y, Nishikawa RM (2004) Radial gradient-based segmentation of mammographic microcalcifications: observer evaluation and effect on CAD performance. Med Phys 31:2648-2657 (Pubitemid 39287882)
38. Chabat F, Desai SR, Hansell DM, Yang GZ (2000) Gradient correction and classification of CT lung images for the automated quantification of mosaic attenuation pattern. J Comput Assist Tomogr 24:437-447 (Pubitemid 32203938)
39. Haris K, Efstratiadis SN, Maglaveras N, Pappas C, Gourassas J, Louridas G (1999) Model-based morphological segmentation and labeling of coronary angiograms. IEEE Trans Med Imaging 18:1003-1015 (Pubitemid 32211115)
40. Santos VT, Schiabel H, Goes CE, Benatti RH (2002) A segmentation technique to detect masses in dense breast digitized mammograms. J Digit Imaging 15(Suppl 1):210-213
41. Veenland JF, Link TM, Konermann W, Meier N, Grashuis JL, Gelsema ES (1997) Unraveling the role of structure and density in determining vertebral bone strength. Calcif Tissue Int 61:474-479 (Pubitemid 27528272)
42. Veenland JF, Grashuis JL, Gelsema ES (1998) Texture analysis in radiographs: the influence of modulation transfer function and noise on the discriminative ability of texture features. Med Phys 25:922-936
43. Lochmüller EM, Krefting N, Burklein D, Eckstein F (2001) Effect of fixation, soft-tissues, and scan projection on bone mineral measurements with dual energy X-ray absorptiometry (DXA). Calcif Tissue Int 68:140-145 (Pubitemid 32374473)
44. Eckstein F, Wunderer C, Boehm H, Kuhn V, Priemel M, Link TM, Lochmüller EM (2004) Reproducibility and side differences of mechanical tests for determining the structural strength of the proximal femur. J Bone Miner Res 19:379-385 (Pubitemid 38787392)
45. Eckstein F, Lochmüller EM, Lill CA, Kuhn V, Schneider E, Delling G, Müller R (2002) Bone strength at clinically relevant sites displays substantial heterogeneity and is best predicted from site-specific bone densitometry. J Bone Miner Res 17:162-171 (Pubitemid 33151008)
46. Lochmüller EM, Groll O, Kuhn V, Eckstein F (2002) Mechanical strength of the proximal femur as predicted from geometric and densitometric bone properties at the lower limb versus the distal radius. Bone 30:207-216 (Pubitemid 34048324)
47. Lochmüller EM, Müller R, Kuhn V, Lill CA, Eckstein F (2003) Can novel clinical densitometric techniques replace or improve DXA in predicting bone strength in osteoporosis at the hip and other skeletal sites? J Bone Miner Res 18:906-912
48. Pulkkinen P, Luomala M, Obregon V, Jämsä T (2005) Gradient-based method for the assessment of trabecular structure from radiographs. IFMBE Proceedings 12
49. Glüer CC, Blake G, Lu Y, Blunt BA, Jergas M, Genant HK (1995) Accurate assessment of precision errors: how to measure the reproducibility of bone densitometry techniques. Osteoporos Int 5:262-270
50. Pulkkinen P, Eckstein F, Lochmuller EM, Kuhn V, Jämsä T (2006) Association of geometric factors and failure load level with the distribution of cervical vs. trochanteric hip fractures. J Bone Miner Res 21:895-901 (Pubitemid 43787996)
51. Duboeuf F, Hans D, Schott AM, Kotzki PO, Favier F, Marcelli C, Meunier PJ, Delmas PD (1997) Different morphometric and densitometric parameters predict cervical and trochanteric hip fracture: the EPIDOS Study. J Bone Miner Res 12:1895-1902 (Pubitemid 27500201)
52. Gnudi S, Malavolta N, Testi D, Viceconti M (2004) Differences in proximal femur geometry distinguish vertebral from femoral neck fractures in osteoporotic women. Br J Radiol 77:219-223 (Pubitemid 38404788)
53. Bergot C, Bousson V, Meunier A, Laval-Jeantet M, Laredo JD (2002) Hip fracture risk and proximal femur geometry from DXA scans. Osteoporos Int 13:542-550 (Pubitemid 34790626)
54. Karlsson KM, Sernbo I, Obrant KJ, Redlund-Johnell I, Johnell O (1996) Femoral neck geometry and radiographic signs of osteoporosis as predictors of hip fracture. Bone 18:327-330 (Pubitemid 26149343)
55. Center JR, Nguyen TV, Pocock NA, Noakes KA, Kelly PJ, Eisman JA, Sambrook PN (1998) Femoral neck axis length, height loss and risk of hip fracture in males and females. Osteoporos Int 8:75-81
56. Portero NR, Arlot ME, Roux JP, Duboeuf F, Chavassieux PM, Meunier PJ (2005) Evaluation and development of automatic two-dimensional measurements of histomorphometric parameters reflecting trabecular bone connectivity: correlations with dual-energy x-ray absorptiometry and quantitative ultrasound in human calcaneum. Calcif Tissue Int 77:195-204 (Pubitemid 41531499)
57. Augat P, Reeb H, Claes LE (1996) Prediction of fracture load at different skeletal sites by geometric properties of the cortical shell. J Bone Miner Res 11:1356-1363 (Pubitemid 26282537)
58. Szulc P, Duboeuf F, Schott AM, Dargent-Molina P, Meunier PJ, Delmas PD (2006) Structural determinants of hip fracture in elderly women: re-analysis of the data from the EPIDOS study. Osteoporos Int 17:231-236 (Pubitemid 43053586)
59. Krug R, Banerjee S, Han ET, Newitt DC, Link TM, Majumdar S (2005) Feasibility of in vivo structural analysis of high-resolution magnetic resonance images of the proximal femur. Osteoporos Int 16:1307-1314 (Pubitemid 41532082)
60. Stauber M, Müller R (2006) Age-related changes in trabecular bone microstructures: global and local morphometry. Osteoporos Int 17:616-626
61. Wigderowitz CA, Abel EW, Rowley DI (1997) Evaluation of cancellous structure in the distal radius using spectral analysis. Clin Orthop Relat Res 335:152-161
62. Veenland JF, Grashius JL, van der Meer F, Beckers AL, Gelsema ES (1996) Estimation of fractal dimension in radiographs. Med Phys 23:585-594
63. Chappard D, Guggenbuhl P, Legrand E, Basle MF, Audran M (2005) Texture analysis of X-ray radiographs is correlated with bone histomorphometry. J Bone Miner Metab 23:24-29