Mapping a locus for alcohol physical dependence and associated withdrawal to a 1.1 Mb interval of mouse chromosome 1 syntenic with human chromosome 1q23.2-23.3

Genes, Brain and Behavior

Volumn 7, Issue 5, 2008, Pages 560-567

  Kozell, L ^a   Belknap, J K ^a   Hofstetter, J R ^b,c   Mayeda, A ^b,c   Buck, K J ^a,d  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

C57BL 6J (B6); Convulsion; DBA 2J (D2); Ethanol; Interval specific congenic strain; Quantitative trait locus

Indexed keywords

ALCOHOL;

ALCOHOL CONSUMPTION; ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMOSOME 1; CONGENIC STRAIN; FEMALE; GENE LOCUS; GENE MAPPING; GENETIC ANALYSIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ACUTE DISEASE; ALCOHOL WITHDRAWAL SEIZURES; ALCOHOLISM; ANIMALS; CHROMOSOME MAPPING; CHROMOSOMES, MAMMALIAN; GABA MODULATORS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MICE; MICE, CONGENIC; MICE, INBRED C57BL; MICE, INBRED DBA; PENTOBARBITAL; PHENOTYPE; QUANTITATIVE TRAIT LOCI; SUBSTANCE WITHDRAWAL SYNDROME;

ANIMALIA; MUS;

EID: 47249098328     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2008.00391.x     Document Type: Article

References (45)

1. Aragaki, C., Quiaoit, F., Hsu, L. Zhao, L.P. (1999) Mapping alcoholism genes using linkage/linkage disequilibrium analysis. Genet Epidemiol 17 (Suppl. 1 S43 S48.
2. Belknap, J.K., Laursen, S.E. Crabbe, J.C. (1987) Ethanol and nitrous oxide produce withdrawal-induced convulsions by similar mechanisms in mice. Life Sci 41, 2033 2040.
3. Buck, K.J., Metten, P., Belknap, J.K. Crabbe, J.C. (1997) QTL involved in genetic predisposition to acute alcohol withdrawal in mice. J Neurosci 17, 3946 3955.
4. Buck, K.J., Metten, P., Belknap, J.K. Crabbe, J.C. (1999) QTL affecting risk for pentobarbital withdrawal map near alcohol withdrawal loci on mouse chromosomes 1, 4, and 11. Mamm Genome 10, 431 437.
5. Buck, K.J., Rademacher, B.S., Metten, P. Crabbe, J.C. (2002) Mapping murine loci for physical dependence on ethanol. Psychopharmacology (Berl) 160, 398 407.
6. Cicila, G.T., Garrett, M.R., Lee, S.J., Liu, J., Dene, H. Rapp, J.P. (2001) High-resolution mapping of the blood pressure QTL on chromosome 7 using Dahl rat congenic strains. Genomics 72, 51 60.
7. Crabbe, J.C. (1983) Sensitivity to ethanol in inbred mice: genotypic correlations among several behavioral responses. Behav Neurosci 97, 280 289.
8. Crabbe, J.C., Merrill, C. Belknap, J.K. (1991) Acute dependence on depressant drugs is determined by common genes in mice. J Pharmacol Exp Ther 257, 663 667.
9. Crabbe, J.C., Belknap, J.K., Mitchell, S.R. Crawshaw, L.I. (1994) Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice. J Pharmacol Exp Ther 269, 184 192.
10. Darvasi, A. (1997) Interval-specific congenic strains (ISCS): an experimental design for mapping a QTL into a 1-centimorgan interval. Mamm Genome 8, 163 167.
11. Darvasi, A. (1998) Strategies for the dissection of complex traits in animal models. Nat Genet 18, 19 24.
12. Demarest, K., McCaughran, J. Jr., Mahjubi, E., Cipp, L. Hitzemann, R. (1999) Identification of an acute ethanol response quantitative trait locus on mouse chromosome 2. J Neurosci 19, 549 561.
13. Denmark, D. Buck, K. (2008) Molecular analyses and identification of promising candidate genes for loci on mouse chromosome 1 affecting alcohol physical dependence and associated withdrawal. Genes Brain Behav doi: 10.1111/j.1601-183x.2008.00396.
14. Dick, D.M., Nurnberger, J. Jr., Edenberg, H.J., Goate, A., Crowe, R., Rice, J., Bucholz, K.K., Kramer, J., Schuckit, M.A., Smith, T.L., Porjesz, B., Begleiter, H., Hesselbrock, V. Foroud, T. (2002) Suggestive linkage on chromosome 1 for a quantitative alcohol-related phenotype. Alcohol Clin Exp Res 26, 1453 1460.
15. Fehr, C., Shirley, R.L., Belknap, J.K., Crabbe, J.C. Buck, K.J. (2002) Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 cM interval of murine chromosome 4: identification of Mpdz as a candidate gene. J Neurosci 22, 3730 3738.
16. Ferraro, T.N., Golden, G.T., Smith, G.G., Schork, N.J., St Jean, P., Ballas, C., Choi, H. Berrettini, W.H. (1997) Mapping murine loci for seizure response to kainic acid. Mamm Genome 8, 200 208.
17. Ferraro, T.N., Golden, G.T., Smith, G.G., Martin, J.F., Lohoff, F.W., Gieringer, T.A., Zamboni, D., Schwebel, C.L., Press, D.M., Kratzer, S.O., Zhao, H., Berrettini, W.H. Buono, R.J. (2004) Fine mapping of a seizure susceptibility locus on mouse chromosome 1: nomination of Kcnj10 as a causative gene. Mamm Genome 15, 239 251.
18. Ferraro, T.N., Golden, G.T., Dahl, J.P., Smith, G.G., Schwebel, C.L., Macdonald, R., Lohoff, F.W., Berrettini, W.H. Buono, R.J. (2007) Analysis of a quantitative trait locus for seizure susceptibility in mice using bacterial artificial chromosome-mediated gene transfer. Epilepsia 48, 1667 1677.
19. Frankel, W.N., Taylor, B.A., Noebels, J.L. Lutz, C.M. (1994) Genetic epilepsy model derived from common inbred mouse strains. Genetics 138, 481 489.
20. Frankel, W.N., Johnson, E.W. Lutz, C.M. (1995) Congenic strains reveal effects of the epilepsy quantitative trait locus, El2, separate from other El loci. Mamm Genome 6, 839 843.
21. Goldman, D., Oroszi, G., O'Malley, S. Anton, R. (2005) COMBINE genetics study: the pharmacogenetics of alcoholism treatment response: genes and mechanisms. J Stud Alcohol Suppl 15, 56 64 discussion 33.
22. Goldstein, D.B. (1973) Alcohol withdrawal reactions in mice: effects of drugs that modify neurotransmission. J Pharmacol Exp Ther 186, 1 9.
23. Goldstein, D.B. Pal, N. (1971) Alcohol dependence produced in mice by inhalation of ethanol: grading the withdrawal reaction. Science 172, 288 290.
24. Guerrini, I., Cook, C.C., Kest, W., Devitgh, A., McQuillin, A., Curtis, D. Gurling, H.M. (2005) Genetic linkage analysis supports the presence of two susceptibility loci for alcoholism and heavy drinking on chromosome 1p22.1-11.2 and 1q21.3-24.2. BMC Genet 6, 11.
25. Hasin, D.S., Stinson, F.S., Ogburn, E. Grant, B.F. (2007) Prevalence, correlates, disability, and comorbidity of DSMIV alcohol abuse and dependence in the United States. Arch Gen Psychiatry 64, 830 842.
26. Hesselbrock, V., Dick, D., Hesselbrock, M., Foroud, T., Schuckit, M., Edenberg, H., Bucholz, K., Kramer, J., Reich, T., Goate, A., Bierut, L., Rice, J.P. Nurnberger, J.I. Jr. 2004) The search for genetic risk factors associated with suicidal behavior. Alcohol Clin Exp Res 28, 70S 76S.
27. Kakihana, R. (1979) Alcohol intoxication and withdrawal in inbred strains of mice: behavioral and endocrine studies. Behav Neural Biol 26, 97 105.
28. Kosobud, A. Crabbe, J.C. (1986) Ethanol withdrawal in mice bred to be genetically prone or resistant to ethanol withdrawal seizures. J Pharmacol Exp Ther 238, 170 177.
29. Lander, E. Kruglyak, L. (1995) Genetic dissection of complex traits. Nat Genet 11, 241 247.
30. Levental, M. Tabakoff, B. (1980) Sodium-potassium-activated adenosine triphosphatase activity as a measure of neuronal membrane characteristics in ethanol-tolerant mice. J Pharmacol Exp Ther 212, 315 319.
31. Lutz, U.C., Batra, A., Kolb, W., Machiaco, F., Maurer, S. Kohnke, M.D. (2006) Methylenetetrahydrofolate reductase C677T-polymorphism and its association with alcohol withdrawal seizure. Alcohol Clin Exp Res 30, 1966 1971.
32. Lyons, P.A., Armitage, N., Argentina, F., Denny, P., Hill, N.J., Lord, C.J., Wilusz, M.B., Peterson, L.B., Wicker, L.S. Todd, J.A. (2000) Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping. Genome Res 10, 446 453.
33. Martin, B., Clement, Y., Venault, P. Chapouthier, G. (1995) Mouse chromosomes 4 and 13 are involved in beta-carboline-induced seizures. J Hered 86, 274 279.
34. McQuarrie, D.G. Fingl, E. (1958) Effects of single doses and chronic administration of ethanol on experimental seizures in mice. J Pharmacol Exp Ther 124, 264 271.
35. Metten, P. Crabbe, J.C. (1994) Common genetic determinants of severity of acute withdrawal from ethanol, pentobarbital and diazepam in inbred mice. Behav Pharmacol 5, 533 547.
36. Metten, P., Belknap, J.K. Crabbe, J.C. (1998) Drug withdrawal convulsions and susceptibility to convulsants after short-term selective breeding for acute ethanol withdrawal. Behav Brain Res 95, 113 122.
37. van Munster, B.C., Korevaar, J.C., de Rooij, S.E., Levi, M. Zwinderman, A.H. (2007) Genetic polymorphisms related to delirium tremens: a systematic review. Alcohol Clin Exp Res 31, 177 184.
38. Neumann, P.E. Collins, R.L. (1991) Genetic dissection of susceptibility to audiogenic seizures in inbred mice. Proc Natl Acad Sci U S A 88, 5408 5412.
39. Risinger, F.O. Cunningham, C.L. (1998) Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice. Alcohol Clin Exp Res 22, 1234 1244.
40. Schaumann, B.A., Annegers, J.F., Johnson, S.B., Moore, K.J., Lubozynski, M.F. Salinsky, M.C. (1994) Family history of seizures in posttraumatic and alcohol-associated seizure disorders. Epilepsia 35, 48 52.
41. Shirley, R.L., Walter, N.A., Reilly, M.T., Fehr, C. Buck, K.J. (2004) Mpdz is a quantitative trait gene for drug withdrawal seizures. Nat Neurosci 7, 699 700.
42. Tarantino, L.M., McClearn, G.E., Rodriguez, L.A. Plomin, R. (1998) Confirmation of quantitative trait loci for alcohol preference in mice. Alcohol Clin Exp Res 22, 1099 1105.
43. Taylor, B.A. Frankel, W.N. (1993) A new strain congenic for the Mtv-7/Mls-1 locus of mouse chromosome 1. Immunogenetics 38, 235 237.
44. Terdal, E.S. Crabbe, J.C. (1994) Indexing withdrawal in mice: matching genotypes for exposure in studies using ethanol vapor inhalation. Alcohol Clin Exp Res 18, 542 547.
45. Turecki, G., Rouleau, G.A. Alda, M. (1999) Family density of alcoholism and linkage information in the analysis of the COGA data. Genet Epidemiol 17, S361 366.