Acidic preparations of platelet concentrates release bone morphogenetic protein-2

Acta Orthopaedica

Volumn 79, Issue 3, 2008, Pages 433-437

  Wahlström, Ola ^a   Linder, Cecilia ^b   Kalén, Anders ^a   Magnusson, Per ^a,b  

^a LINKÖPING UNIVERSITY   (Sweden)

^b LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; BUFFER; GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR; THROMBOCYTE CONCENTRATE; TRANSFORMING GROWTH FACTOR; VASCULOTROPIN; BONE MORPHOGENETIC PROTEIN; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN A;

ACIDITY; ARTICLE; CONTROLLED STUDY; CYTOLYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FRACTURE FIXATION; FRACTURE HEALING; HUMAN; LEUKOCYTE; PH; PROTEIN SECRETION; QUANTITATIVE ANALYSIS; THROMBOCYTE; THROMBOCYTE RELEASE REACTION; PHYSIOLOGY; SECRETION;

BLOOD PLATELETS; BONE MORPHOGENETIC PROTEINS; FRACTURE HEALING; HUMANS; HYDROGEN-ION CONCENTRATION; PLATELET-DERIVED GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 47249097537     PISSN: 17453674     EISSN: 17453682     Source Type: Journal    
DOI: 10.1080/17453670710015364     Document Type: Article

References (19)

1. Carreon L Y, Glassman S D, Anekstein Y, Puno R M. Platelet gel (AGF) fails to increase fusion rates in instrumented posterolateral fusions. Spine 2005; 30: E243-6.
2. Dallari D, Fini M, Stagni C, Torricelli P, Nicoli Aldini N, Giavaresi G, Cenni E, Baldini N, Cenacchi A, Bassi A, Giardino R, Fornasari P M, Giunti A. In vivo study on the healing of bone defects treated with bone marrow stromal cells, platelet-rich plasma, and freeze-dried bone allografts, alone and in combination. J Orthop Res 2006; 24: 877-88.
3. Govender S, Csimma C, Genant H K, et al. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg (Am) 2002; 84: 2123-34.
4. Gruber R, Karreth F, Kandler B, Fuerst G, Rot A, Fischer M B, Watzek G. Platelet-released supernatants increase migration and proliferation, and decrease osteogenic differentiation of bone marrow-derived mesenchymal progenitor cells under in vitro conditions. Platelets 2004; 15: 29-35.
5. Gruber R, Kandler B, Fischer M B, Watzek G. Osteogenic differentiation induced by bone morphogenetic proteins can be suppressed by platelet-released supernatant in vitro. Clin Oral Implants Res 2006; 17: 188-93.
6. Hollinger J, Wong M E K. The integrated process of hard tissue regeneration with special emphasis on fracture healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996; 82: 594-606.
7. Jäger M, Fischer J, Schultheis A, Lensing-Höhn S, Krauspe R. Extensive H+ release by bone substitutes affects biocompatibility in vitro testing. J Biomed Mater Res A 2006; 76: 310-22.
8. Liu Y, Kalén A, Risto O, Wahlström O. Fibroblast proliferation due to exposure to a platelet concentrate in vitro is pH dependent. Wound Rep Reg 2002; 10: 336-40.
9. Liu Y, Kalén A, Risto O, Wahlström O. Time- and pH-dependent release of PDGF and TGF-beta from platelets in vitro. Platelets 2003; 14: 233-7.
10. Marx R E. Platelet-rich plasma: Evidence to support its use. J Oral Maxillofac Surg 2004; 62: 489-96.
11. Marx R E, Carlson E R, Eichstaedt R M, Schimmele S R, Strauss J E, Georgeff K R. Platelet-rich plasma. Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998; 85: 638-46.
12. Nikolidakis D, van den Dolder J, Wolke J G, Stoelinga P J, Jansen J A. The effect of platelet-rich plasma on the bone healing around calcium phosphate-coated and non-coated oral implants in trabecular bone. Tissue Eng 2006; 12: 2555-63.
13. Roldán J C, Jepsen S, Miller J, Freitag S, Rueger D C, Açil Y, Terheyden H. Bone formation in the presence of platelet-rich plasma vs. bone morphogenetic protein-7. Bone 2004; 34: 80-90.
14. Sipe J B, Zhang J, Waits C, Skikne B, Garimella R, Anderson H C. Localization of bone morphogenetic proteins (BMPs)-2, -4, and -6 within megakaryocytes and platelets. Bone 2004; 35: 1316-22.
15. Slater M, Patava J, Kingham K, Mason R S. Involvement of platelets in stimulating osteogenic activity. J Orthop Res 1995; 13: 655-63.
16. Steed D L, Goslen J B, Holloway G A, Malone J M, Bunt T J, Webster M W. Randomized prospective double-blind trial in healing chronic diabetic foot ulcers. CT-102 activated platelet supernatant, topical versus placebo. Diabetes Care 1992; 15: 1598-604.
17. Tsuji K, Bandyopadhyay A, Harfe B D, Cox K, Kakar S, Gerstenfeld L, Einhorn T, Tabin C J, Rosen V. BMP2 activity, although dispensable for bone formation, is required for initiation of fracture healing. Nat Genet 2006; 38: 1424-9.
18. Vogel J P, Szalay K, Geiger F, Kramer M, Richter W, Kasten P. Platelet-rich plasma improves expansion of human mesenchymal stem cells and retains differentiation capacity and in vivo bone formation in calcium phosphate ceramics. Platelets 2006; 17: 462-9.
19. Wahlström O, Linder C, Kalén A, Magnusson P. Variation of pH in lysed platelet concentrates influence proliferation and alkaline phosphatase activity in human osteoblast-like cells. Platelets 2007; 18: 113-8.