Pharmacokinetics and metabolism of diltiazem following multiple doses:Comparing normotensive rat vs. hypertensive rat models In vivo

Drug Metabolism Letters

Volumn 2, Issue 2, 2008, Pages 146-150

  Yeung, Pollen K F ^a   Alcos, Angelita ^a   Tang, Jinglan ^a   Casley, William I ^b  

^a DALHOUSIE UNIVERSITY   (Canada)

^b Health Canada and World Health Organization Collaborating Center for Standardization and Evaluation of Biologicals   (Canada)

Author keywords

Diltiazom; Metabolism; Pharmacokinetics; Rats; SHR

Indexed keywords

DILTIAZEM;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG METABOLISM; DRUG RESEARCH; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPERTENSION; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; PRIORITY JOURNAL; RAT; RODENT; SPONTANEOUSLY HYPERTENSIVE RAT; SPRAGUE DAWLEY RAT; STATISTICAL SIGNIFICANCE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; CALCIUM CHANNEL BLOCKERS; DILTIAZEM; DRUG EVALUATION, PRECLINICAL; INJECTIONS, SUBCUTANEOUS; MALE; MODELS, ANIMAL; RATS; RATS, INBRED SHR; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY;

RATTUS; RODENTIA;

EID: 47249096631     PISSN: 18723128     EISSN: None     Source Type: Journal    
DOI: 10.2174/187231208784040915     Document Type: Article

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