Steady-state plasma concentrations of diltiazem and its metabolites in patients and healthy volunteers

Therapeutic Drug Monitoring

Volumn 18, Issue 1, 1996, Pages 40-45

  Yeung, Pollen K F ^a   Buckley, Susan J ^a   Hung, Orlando R ^a   Pollak, P Timothy ^a   Barclay, Katherine D ^a   Feng, Joe D Z ^a   Farmer, Patrick S ^a   Klassen, Gerald A ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Diltiazem; Diltiazem metabolites

Indexed keywords

ACETONITRILE; AMMONIUM ACETATE; CALCIUM ANTAGONIST; DILTIAZEM; DRUG METABOLITE; METHANOL; N,O DINORDILTIAZEM; O NORDILTIAZEM; TRIETHYLAMINE; UNCLASSIFIED DRUG; VERAPAMIL;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG METABOLISM; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; ISCHEMIC HEART DISEASE; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; STEADY STATE;

AGED; BIOTRANSFORMATION; CALCIUM CHANNEL BLOCKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DILTIAZEM; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA; PILOT PROJECTS; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0030053219     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-199602000-00007     Document Type: Article

References (21)

1. Bourassa MG. Haemodynamic and electrophysiologic effects of diltiazem. Acta Pharmacol Toxicol 1985;57(suppl II):21-30.
2. Burgess J, Gray J. When and how to use calcium channel blockers. Patient Care 1992;May:22-32.
3. Medical Letter. Drugs for hypertension. Med Lett 1993;35: 55-60.
4. Sugihara J, Sugawara Y, Ando H, Harigaya S, Etoh A, Kohno K. Studies on the metabolism of diltiazem in man. J Pharmacobiodyn 1984;7:24-32.
5. Yabana H, Nagao T, Sato M. Cardiovascular effects of the metabolites of diltiazem in dogs. J Cardiovasc Pharmacol 1985;7:152-7.
6. Sugawara Y, Nakamura S, Usuki S, et al. Metabolism of diltiazem II. Metabolic profile in rat, dog and man. J Pharmacobiodyn 1988;11:224-33.
7. Yeung PKF, Mosher SJ, MacRae DA, Klassen GA. Effect of diltiazem and its metabolites on the uptake of adenosine in blood: an in-vitro investigation. J Pharm Pharmacol 1991; 43:685-9.
8. Yeung P, Mosher S, Li R, et al. Erythrocyte adenosine transport: a rapid screening test for cardiovascular drugs. J Pharmacol Methods 1993;30:163-7.
9. Tawashi M, Marc-Aurele J, Bichet D, et al. Pharmacokinetics of oral diltiazem and five of its metabolites in patients with chronic renal failure. Biopharm Drug Dispos 1991;12: 95-104.
10. Hussain M, Tam Y, Finegan B, Coutts R. Simple and sensitive high-performance liquid chromatographic method for the determination of diltiazem and six of its metabolites in human plasma. J Chromatogr 1992;582:203-9.
11. Yeung P, Prescott C, Haddad C, et al. Pharmacokinetics and metabolism of diltiazem in healthy males and females following a single oral dose. Eur J Drug Metab Pharmacokinet 1993;18:199-206.
12. Yeung PKF, Mosher SJ, Klassen GA, McGilveray IJ. Stability of diltiazem and its metabolites in plasma during storage. Ther Drug Monit 1991;13:369-74.
13. Kiyomoto A, Sasaki Y, Odawara A, Morita T. Inhibition of platelet aggregation by diltiazem. Circ Res 1983;52(suppl I): 115-9.
14. Schwartz JB, Abernethy DR. Responses to intravenous and oral diltiazem in elderly and younger patients with systemic hypertension. Am J Cardiol 1987;59:1111-7.
15. Argenti D, Huang M-Y, Heald D, Ziemniak J. Comparative pharmacokinetics of diltiazem SR in elderly vs young hypertensive patients. Pharmacol Res 1993;10(suppl):312.
16. Montamat SC, Abernethy DR. N-monodesmethyldiltiazem is the predominant metabolite of diltiazem in the plasma of young and elderly hypertensives. Br J Clin Pharmacol 1987; 24:185-9.
17. Li R, Farmer PS, Xie M, et al. Synthesis, characterization and calcium antagonistic activity of diltiazem metabolites. J Med Chem 1992;35:3246-53.
18. Yeung PKF, Montague TJ, Tsui B, McGregor C. High performance liquid chromatographic assay of diltiazem and six of its metabolites in plasma: application to a pharmacokinetic study in healthy volunteers. J Pharm Sci 1989;78:592-7.
19. Gibaldi M, Perrier D, eds. Pharmacokinetics. New York: Marcel Dekker, 1982.
20. Caille G, Boucher S, Spenard J, et al. Diltiazem pharmacokinetics in elderly volunteers after single and multiple doses. Eur J Drug Metab Pharmacokinet 1991;16:75-80.
21. Klassen G, Yeung P, Barclay K, Hung O, Pollak P, Buckley S. Gender differences in diltiazem's action to lower blood pressure. Circulation 1994;90(Pt 2):I-505.