Endothelin receptor blockers protect against ischemia/reperfusion impairment of gastrointestinal motility in rats

Pharmacological Research

Volumn 57, Issue 6, 2008, Pages 413-418

  Lugowska Umer H ^a   Umer, A ^a   Sein Anand, J ^a   Sokolowska Wojdylo M ^a   Wlodarkiewicz A ^a   Korolkiewicz, R P ^a  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

Endothelins; Gastrointestinal motility rats; Ischemia reperfusion

Indexed keywords

CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; EVANS BLUE; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; TEZOSENTAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG DOSE COMPARISON; DRUG EFFECT; GASTROINTESTINAL MOTILITY DISORDER; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ISCHEMIA; INTESTINE MOTILITY; INTESTINE MUSCLE; JEJUNUM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SKIN INCISION; SUPERIOR MESENTERIC ARTERY;

ANESTHESIA, INHALATION; ANESTHETICS, INHALATION; ANIMALS; CARBACHOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIN-1; ETHER, ETHYL; EVANS BLUE; GASTROINTESTINAL MOTILITY; MALE; MUSCARINIC AGONISTS; OLIGOPEPTIDES; PEPTIDES, CYCLIC; PIPERIDINES; PYRIDINES; RATS; RATS, WISTAR; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; RECEPTORS, ENDOTHELIN; REPERFUSION INJURY; SURGICAL PROCEDURES, OPERATIVE; TETRAZOLES;

EID: 47249093638     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2008.04.003     Document Type: Article

References (31)

1. Yasuhara H. Acute mesenteric ischemia: the challenge of gastroenterology. Surg Today 35 (2005) 185-195
2. Collard C.D., and Gelman S. Pathophysiology, clinical manifestations, and prevention of ischemia-reperfusion injury. Anesthesiology 94 (2001) 1133-1138
3. Mallick I.H., Yang W., Winslet M.C., and Seifalian A.M. Ischemia-reperfusion injury of the intestine and protective strategies against injury. Dig Dis Sci 49 (2004) 1359-1377
4. Goyal R.K., and Hirano I. The enteric nervous system. N Engl J Med 334 (1996) 1106-1115
5. Lázár Z., Benkó R., Bölcskei K., Rumbus Z., Wolf M., Holzer P., et al. Actions of endothelin and corticotropin releasing factor in the guinea-pig ileum: no evidence for an interaction with capsaicin-sensitive neurons. Neuropeptides 37 (2003) 220-232
6. Masaki T. Historical review: endothelin. Trends Pharmacol Sci 25 (2004) 219-224
7. Huang S.C. Endothelin receptors in gastrointestinal smooth muscle. Curr Protein Pept Sci 6 (2005) 547-557
8. Chen C.Y., Lu C.L., Chang F.Y., Lu R.H., Ng W.W., and Lee S.D. Endothelin-1 is a candidate mediating intestinal dysmotility in patients with acute pancreatitis. Dig Dis Sci 44 (1999) 922-926
9. B receptors. J Pharmacol Exp Ther 276 (1996) 647-651
10. Alican I., Yegen C., Olcay A., Kurtel H., and Yegen B. Ischemia-reperfusion-induced delay in intestinal transit. Role of endothelins. Digestion 59 (1998) 343-348
11. Unlüer E.E., Alican I., Yegen C., and Yegen B.C. The delays in intestinal motility and neutrophil infiltration following burn injury in rats involve endogenous endothelins. Burns 26 (2000) 335-340
12. Greenwood-Van Meerveld B., Venkova K., and Keith Jr. J.C. Recombinant human interleukin-11 restores smooth muscle function in the jejunum and colon of human leukocyte antigen-B27 rats with intestinal inflammation. J Pharmacol Exp Ther 299 (2001) 58-66
13. Tallarida R.J., and Murray R.B. Manual of pharmacologic calculations with computer programs. 2nd ed. (1986), Springer Verlag, New York
14. Kuwahara K., Kitsukawa Y., Suzuki Y., and Saito Y. Effects of several endothelin receptor antagonists on gastrointestinal transit of guinea pigs. Dig Dis Sci 45 (2000) 960-966
15. A receptor blockade potentiates morphine analgesia but does not affect gastrointestinal transit in mice. Eur J Pharmacol 543 (2006) 48-53
16. Al-Jiffry B.O., Toouli J., and Saccone G.T. Endothelin-3 induces both human and opossum gallbladder contraction mediated mainly by endothelin-B receptor subtype in vitro. J Gastroenterol Hepatol 17 (2002) 324-331
17. Hassoun H.T., Weisbrodt N.W., Mercer D.W., Kozar R.A., Moody F.G., and Moore F.A. Inducible nitric oxide synthase mediates gut ischemia/reperfusion-induced ileus only after severe insults. J Surg Res 97 (2001) 150-154
18. Udassin R., Eimerl D., Schiffman J., and Haskel Y. Postischemic intestinal motility in rat is inversely correlated to length of ischemia. An in vivo animal model. Dig Dis Sci 40 (1995) 1035-1038
19. Sunose Y., Ohwada S., Takeyoshi I., Matsumoto K., Tsutsumi H., Tomizawa N., et al. Effects of endothelin receptor antagonist TAK-044 on small bowel autograft from a controlled non-heart-beating donor model. Surgery 130 (2001) 819-825
20. Oktar B.K., Coskun T., Bozkurt A., Yegen B.C., Yuksel M., Haklar G., et al. Endothelin-1-induced PMN infiltration and mucosal dysfunction in the rat small intestine. Am J Physiol Gastrointest Liver Physiol 279 (2000) G483-G491
21. Anthoni C., Mennigen R.B., Rijcken E.J., Laukötter M.G., Spiegel H.U., Senninger N., et al. Bosentan, an endothelin receptor antagonist, reduces leucocyte adhesion and inflammation in a murine model of inflammatory bowel disease. Int J Colorectal Dis 21 (2006) 409-418
22. B receptors in rats. J Pharmacol Exp Ther 315 (2005) 609-615
23. B receptor function in pancreatitis-associated microcirculatory failure, inflammation, and parenchymal injury. Am J Physiol Gastrointest Liver Physiol 285 (2003) G145-153
24. Yamanaka N., Takaya Y., Oriyama T., Furukawa K., Tanaka T., Tanaka W., et al. Hepatoprotective effect of a nonselective endothelin receptor antagonist (TAK-044) in the transplanted liver. J Surg Res 70 (1997) 156-160
25. Löffler B.M., Breu V., and Clozel M. Effect of different endothelin receptor antagonists and of the novel non-peptide antagonist Ro 46-2005 on endothelin levels in rat plasma. FEBS Lett 333 (1993) 108-110
26. Clozel M., Ramuz H., Clozel J.P., Breu V., Hess P., Löffler B.M., et al. Pharmacology of tezosentan, new endothelin receptor antagonist designed for parenteral use. J Pharmacol Exp Ther 290 (1999) 840-846
27. Hiramoto Y., Shioyama W., Kuroda T., Masaki M., Sugiyama S., Okamoto K., et al. Effect of bosentan on plasma endothelin-1 concentration in patients with pulmonary arterial hypertension. Circ J 71 (2007) 367-369
28. Rukebusch M., and Fioramonti J. Electrical spiking activity and propulsion in small intestine in fed and fasted rats. Gastroenterology 68 (1975) 1500-1508
29. Ruwart M.J., Klepper M.S., and Rush B.D. Adrenergic and cholinergic contributions to decreased gastric emptying, small intestinal transit, and colonic transit in the postoperative ileus rat. J Surg Res 29 (1980) 126-134
30. Kelley M.C., Hocking M.P., Marchand S.D., and Sninsky C.A. Ketorolac prevents postoperative small intestinal ileus in rats. Am J Surg 165 (1993) 107-111
31. Person B., and Wexner S.D. The management of postoperative ileus. Curr Probl Surg 43 (2006) 6-65