Recombinant human interleukin-11 restores smooth muscle function in the jejunum and colon of human leukocyte antigen-B27 rats with intestinal inflammation

Journal of Pharmacology and Experimental Therapeutics

Volumn 299, Issue 1, 2001, Pages 58-66

  Greenwood Van Meerveld, Beverley ^a,c   Venkova, Kalina ^a   Keith Jr , James C ^b  

^a Oklahoma Foundation for Digestive Research   (United States)

^b PFIZER INC   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBACHOL; HLA B27 ANTIGEN; MYELOPEROXIDASE; PLACEBO; POTASSIUM CHLORIDE; RECOMBINANT INTERLEUKIN 11;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHRONIC DIARRHEA; COLON; COLON INJURY; CONTROLLED STUDY; ELECTROSTIMULATION; ENTERIC COATED TABLET; ENTERITIS; ENZYME ACTIVITY; HISTOLOGY; INTESTINE MUCOSA; INTESTINE MUSCLE; JEJUNUM; MALE; MUSCLE ISOMETRIC CONTRACTION; MUSCLE TONE; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTILITY; TRANSGENE;

ANIMALS; COLON; DOSE-RESPONSE RELATIONSHIP, DRUG; ENTERITIS; FECES; HLA-B27 ANTIGEN; INTERLEUKIN-11; JEJUNUM; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PARASYMPATHETIC NERVOUS SYSTEM; PEROXIDASE; RATS; RATS, INBRED F344; RECOMBINANT PROTEINS;

EID: 0034807576     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. The effect of anti-inflammatory drugs on eicosanoid formation in a chronic model of inflammatory bowel disease in the rat
2. T cells, but not thymic exposure to HLA-B27, are required for the inflammatory disease of HLA-B27 transgenic rats
3. Transfer of the inflammatory disease of HLA-B27 transgenic rats by bone marrow engraftment
4. IL-11 inhibits Clostridium difficile toxin A enterotoxicity in rat ileum
5. Trichinella spiralis: Peroxidase activity in isolated cells from the rat intestine
6. Impaired acetylcholine release from the myenteric plexus of Trichinella-infected rats
7. Effects of inflammation of enteric nerves. Cytokine-induced changes in neurotransmitter contents and release
8. A bone marrow stromal-derived growth factor, interleukin-11, stimulates recovery of small intestinal mucosal cells after cytoablative therapy
9. Protective effects of interleukin-11 in a murine model of ischemic bowel necrosis
10. Mechanical properties of smooth muscle. I. Length-tension and force-velocity relations
11. Collagen content and types in the intestinal strictures of Crohn's disease
12. Recombinant human interleukin-11 modulates ion transport and mucosal inflammation in the small intestine and colon
13. On the specificity of altered muscle function in experimental colitis in rats
14. Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human β2m: An animal model of HLA-B27-associated human disorders
15. Cytokine messenger RNA profiles in inflammatory bowel disease mucosa detected by polymerase chain reaction amplification
16. IL-11, a pleiotropic cytokine: Exciting new effects of IL-11 on gastrointestinal mucosal biology
17. Interleukin 1 beta induces the expression of interleukin 6 in rat intestinal smooth muscle cells
18. Altered contractility of circular and longitudinal muscle in TNBS-inflamed guinea pigileum
19. Altered smooth muscle function in worm-free gut regions of Trichinella-infected rats
20. Cytokines increase proliferation of human intestinal smooth muscle cells: Possible role in inflammation-induced stricture formation
21. Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine
22. Stromal cell associated hematopoiesis: Immortalization and characterization of a primate bone marrow-derived stromal cell line
23. Interleukin-11 induces intestinal epithelial cell growth arrest through effects on retinoblastoma protein phosphorylation
24. Molecular effects of recombinant human interleukin-11 in the HLA-B27 rat model of inflammatory bowel disease
25. Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta-2 microglobulin transgenic rats
26. Preliminary evaluation of safety and activity of recombinant human interleukin 11 in patients with active Crohn's disease
27. Defect in colonic muscle contraction in patients with ulcerative colitis
28. Increased collagen type III synthesis in fibroblasts isolated from strictures of patients with Crohn's disease
29. Impaired sympathetic nerve function in the inflamed rat intestine
30. Monokine stimulation of interleukin-11 production by human vascular smooth muscle cells in vitro
31. Susceptibility to inflammatory disease in HLA-B27 transgenic rat lines correlates with the level of B27 expression
32. The germ-free state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats
33. Recombinant human IL-11 attenuates the inflammatory response through down-regulation of proinflammatory cytokine release and nitric oxide production
34. IL-11 regulates macrophage effector function through inhibition of nuclear factor-κB
35. In vivo absorption of orally administrated recombinant human interleukin-11
36. Protection by recombinant human interleukin-11 against experimental TNB-induced colitis in rats
37. Neuromuscular dysfunction in the jejunum and colon of HLA-B27 transgenic rats
38. Altered small intestinal smooth muscle function in Crohn's disease