메뉴 건너뛰기




Volumn 4, Issue 3, 2008, Pages 333-340

Ixabepilone for the treatment of taxane-refractory breast cancer

Author keywords

BMS 247550; Breast cancer; Chemotherapy; Ixabepilone; Metastatic

Indexed keywords

ANTHRACYCLINE DERIVATIVE; BETA TUBULIN; CAPECITABINE; CREMOPHOR; EPOTHILONE B; EPOTHILONE D; EPOTHILONE DERIVATIVE; IXABEPILONE; IXEMPRA; TAXANE DERIVATIVE; TRASTUZUMAB; ZK EPO;

EID: 47249087285     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/14796694.4.3.333     Document Type: Review
Times cited : (3)

References (39)
  • 1
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 365(9472), 1687-1717 (2005).
    • (2005) Lancet , vol.365 , Issue.9472 , pp. 1687-1717
  • 2
    • 0037301972 scopus 로고    scopus 로고
    • Survival of patients with metastatic breast carcinoma: Importance of prognostic markers of the primary tumor
    • Chang J, Clark GM, Allred DC, Mohsin S, Chamness G, Elledge RM: Survival of patients with metastatic breast carcinoma: importance of prognostic markers of the primary tumor. Cancer 97(3), 545-553 (2003).
    • (2003) Cancer , vol.97 , Issue.3 , pp. 545-553
    • Chang, J.1    Clark, G.M.2    Allred, D.C.3    Mohsin, S.4    Chamness, G.5    Elledge, R.M.6
  • 3
    • 0023145358 scopus 로고
    • Survival from first recurrence: Relative importance of prognostic factors in 1,015 breast cancer patients
    • Clark GM, Sledge GW Jr, Osborne CK, McGuire WL: Survival from first recurrence: relative importance of prognostic factors in 1,015 breast cancer patients. J. Clin. Oncol. 5(1), 55-61 (1987).
    • (1987) J. Clin. Oncol , vol.5 , Issue.1 , pp. 55-61
    • Clark, G.M.1    Sledge Jr, G.W.2    Osborne, C.K.3    McGuire, W.L.4
  • 4
    • 0032949449 scopus 로고    scopus 로고
    • Prospective randomized trial of docetaxel versus mitomycin plus vinblastine in patients with metastatic breast cancer progressing despite previous andiracycline-containing chemotherapy. 304 Study Group
    • Nabholtz JM, Senn HJ, Bewoda WR et al.: Prospective randomized trial of docetaxel versus mitomycin plus vinblastine in patients with metastatic breast cancer progressing despite previous andiracycline-containing chemotherapy. 304 Study Group. J. Clin. Oncol. 17(5), 1413-1424 (1999).
    • (1999) J. Clin. Oncol , vol.17 , Issue.5 , pp. 1413-1424
    • Nabholtz, J.M.1    Senn, H.J.2    Bewoda, W.R.3
  • 5
    • 0032809977 scopus 로고    scopus 로고
    • Initial paclitaxel improves outcome compared with CMFP combination chemotherapy as frontline therapy in untreated metastatic breast cancer
    • Bishop JF, Dewar J, Toner GC et al.: Initial paclitaxel improves outcome compared with CMFP combination chemotherapy as frontline therapy in untreated metastatic breast cancer. J. Clin. Oncol. 17 (8), 2355-2364 (1999).
    • (1999) J. Clin. Oncol , vol.17 , Issue.8 , pp. 2355-2364
    • Bishop, J.F.1    Dewar, J.2    Toner, G.C.3
  • 6
    • 0037441856 scopus 로고    scopus 로고
    • Phase III trial of doxorubicin, paclitaxel, and the combination of doxorubicin and paclitaxel as front-line chemotherapy for metastatic breast cancer: An intergroup trial (EI 193)
    • Sledge GW, Neuberg D, Bernardo P et al.: Phase III trial of doxorubicin, paclitaxel, and the combination of doxorubicin and paclitaxel as front-line chemotherapy for metastatic breast cancer: an intergroup trial (EI 193). J. Clin. Oncol. 21(4), 588-592 (2003).
    • (2003) J. Clin. Oncol , vol.21 , Issue.4 , pp. 588-592
    • Sledge, G.W.1    Neuberg, D.2    Bernardo, P.3
  • 7
    • 0032787785 scopus 로고    scopus 로고
    • Prospective randomized trial of docetaxel versus doxorubicin in patients with metastatic breast cancer
    • Chan S, Friedrichs K, Noel D et al.: Prospective randomized trial of docetaxel versus doxorubicin in patients with metastatic breast cancer. J. Clin. Oncol. 17(8), 2341-2354 (1999).
    • (1999) J. Clin. Oncol , vol.17 , Issue.8 , pp. 2341-2354
    • Chan, S.1    Friedrichs, K.2    Noel, D.3
  • 8
    • 24944507764 scopus 로고    scopus 로고
    • Randomized Phase III study of docetaxel compared with paclitaxel in metastatic breast cancer
    • Jones SE, Erban J, Overmoyer B et al.: Randomized Phase III study of docetaxel compared with paclitaxel in metastatic breast cancer. J. Clin. Oncol. 23(24), 5542-5551 (2005).
    • (2005) J. Clin. Oncol , vol.23 , Issue.24 , pp. 5542-5551
    • Jones, S.E.1    Erban, J.2    Overmoyer, B.3
  • 9
    • 32944482677 scopus 로고    scopus 로고
    • Superior efficacy of albumin-bound paclitaxel, ABI-007, compared with polyethylated castor oil-based paclitaxel in women with metastatic breast cancer: Results of a Phase III trial
    • Gradishar WJ, Tjulandin S, Davidson N et al.: Superior efficacy of albumin-bound paclitaxel, ABI-007, compared with polyethylated castor oil-based paclitaxel in women with metastatic breast cancer: results of a Phase III trial. J. Clin. Oncol. 23 (31), 7794-7803 (2005).
    • (2005) J. Clin. Oncol , vol.23 , Issue.31 , pp. 7794-7803
    • Gradishar, W.J.1    Tjulandin, S.2    Davidson, N.3
  • 10
    • 47249118093 scopus 로고    scopus 로고
    • O'Shaughnessy J, Nag S, Calderill-Ruiz G et al.: Gemcitabine plus paclitaxel (GT) versus paclitaxel (T) as first-line treatment for anthracycline pre-treated metastatic breast cancer (MBC), interim results of a global Phase III study. Proc. Am. Soc. Clin. Oncol. 22(7) (2003) (Abstract 25).
    • O'Shaughnessy J, Nag S, Calderill-Ruiz G et al.: Gemcitabine plus paclitaxel (GT) versus paclitaxel (T) as first-line treatment for anthracycline pre-treated metastatic breast cancer (MBC), interim results of a global Phase III study. Proc. Am. Soc. Clin. Oncol. 22(7) (2003) (Abstract 25).
  • 11
    • 17344390083 scopus 로고    scopus 로고
    • Docetaxel compared with sequential methotrexate and 5-fluorouracil in patients with advanced breast cancer after anthracycline failure: A randomised Phase III study wito crossover on progression by the Scandinavian Breast Group
    • Sjostrom J, Blomqvist C, Mouridsen H et al.: Docetaxel compared with sequential methotrexate and 5-fluorouracil in patients with advanced breast cancer after anthracycline failure: a randomised Phase III study wito crossover on progression by the Scandinavian Breast Group. Eur. J. Cancer 35(8), 1194-1201 (1999).
    • (1999) Eur. J. Cancer , vol.35 , Issue.8 , pp. 1194-1201
    • Sjostrom, J.1    Blomqvist, C.2    Mouridsen, H.3
  • 12
    • 0037096755 scopus 로고    scopus 로고
    • Superior survival with capecitabine plus docetaxel combination therapy in anthracycline-pretreated patients with advanced breast cancer: Phase III trial results
    • O'Shaughnessy J, Miles D, Vukelja S et al.: Superior survival with capecitabine plus docetaxel combination therapy in anthracycline-pretreated patients with advanced breast cancer: Phase III trial results. J. Clin. Oncol. 20(12), 2812-2823 (2002).
    • (2002) J. Clin. Oncol , vol.20 , Issue.12 , pp. 2812-2823
    • O'Shaughnessy, J.1    Miles, D.2    Vukelja, S.3
  • 13
    • 0037132372 scopus 로고    scopus 로고
    • Docetaxel vs 5-fluorouracil plus vinorelbine in metastatic breast cancer after anthracycline therapy failure
    • Bonneterre J, Roche H, Monnier A et al.: Docetaxel vs 5-fluorouracil plus vinorelbine in metastatic breast cancer after anthracycline therapy failure. Br. J. Cancer 87(11), 1210-1215 (2002).
    • (2002) Br. J. Cancer , vol.87 , Issue.11 , pp. 1210-1215
    • Bonneterre, J.1    Roche, H.2    Monnier, A.3
  • 14
    • 0036909220 scopus 로고    scopus 로고
    • Single-agent capecitabine: A reference treatment for taxane-pretreated metastatic breast cancer?
    • Seidman AD, O'Shaughnessy J, Misset JL: Single-agent capecitabine: a reference treatment for taxane-pretreated metastatic breast cancer? Oncologist 7 (Suppl. 6), 20-28 (2002).
    • (2002) Oncologist , vol.7 , Issue.SUPPL. 6 , pp. 20-28
    • Seidman, A.D.1    O'Shaughnessy, J.2    Misset, J.L.3
  • 15
    • 18444417397 scopus 로고    scopus 로고
    • Randomised, Phase II trial comparing oral capecitabine (Xeloda) with paclitaxel in patients with metastatic/advanced breast cancer pretreated with anthracyclines
    • Talbot DC, Moiseyenko V, van Belle S et al.: Randomised, Phase II trial comparing oral capecitabine (Xeloda) with paclitaxel in patients with metastatic/advanced breast cancer pretreated with anthracyclines. Br. J. Cancer 86(9), 1367-1372 (2002).
    • (2002) Br. J. Cancer , vol.86 , Issue.9 , pp. 1367-1372
    • Talbot, D.C.1    Moiseyenko, V.2    van Belle, S.3
  • 17
    • 33745262072 scopus 로고    scopus 로고
    • Epothilones in the treatment of cancer
    • Larkin JM, Kaye SB: Epothilones in the treatment of cancer. Expert Opin. Invest. Drugs 15(6), 691-702 (2006).
    • (2006) Expert Opin. Invest. Drugs , vol.15 , Issue.6 , pp. 691-702
    • Larkin, J.M.1    Kaye, S.B.2
  • 18
    • 0029802685 scopus 로고    scopus 로고
    • The microtubule-affecting drug paclitaxel has antiangiogenic activity
    • Belotti D, Vergani V, Drudis T et al.: The microtubule-affecting drug paclitaxel has antiangiogenic activity. Clin. Cancer Res. 2(11), 1843-1849 (1996).
    • (1996) Clin. Cancer Res , vol.2 , Issue.11 , pp. 1843-1849
    • Belotti, D.1    Vergani, V.2    Drudis, T.3
  • 19
    • 0035756986 scopus 로고    scopus 로고
    • Chemistry and chemical biology of taxane anticancer agents
    • Miller ML, Ojima I: Chemistry and chemical biology of taxane anticancer agents. Chem. Rec. 1(3), 195-211 (2001).
    • (2001) Chem. Rec , vol.1 , Issue.3 , pp. 195-211
    • Miller, M.L.1    Ojima, I.2
  • 20
    • 33644977169 scopus 로고    scopus 로고
    • Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of β-tubulin (Asp26Glu) and less stable microtubules
    • Had M, Loganzo F, Annable T et al.: Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of β-tubulin (Asp26Glu) and less stable microtubules. Mol. Cancer Ther. 5(2), 270-278 (2006).
    • (2006) Mol. Cancer Ther , vol.5 , Issue.2 , pp. 270-278
    • Had, M.1    Loganzo, F.2    Annable, T.3
  • 21
    • 3843053396 scopus 로고    scopus 로고
    • The binding mode of epothilone A on α, β-tubulin by electron crystallography
    • Nettles JH, Li H, Cornett B, Krahn JM, Snyder JP, Downing KH: The binding mode of epothilone A on α, β-tubulin by electron crystallography. Science 305(5685), 866-869 (2004).
    • (2004) Science , vol.305 , Issue.5685 , pp. 866-869
    • Nettles, J.H.1    Li, H.2    Cornett, B.3    Krahn, J.M.4    Snyder, J.P.5    Downing, K.H.6
  • 22
    • 0034895987 scopus 로고    scopus 로고
    • BMS-247550: A novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy
    • Lee FY, Borzilleri R, Fairchild CR et al.: BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy. Clin. Cancer Res. 7(5), 1429-1437 (2001).
    • (2001) Clin. Cancer Res , vol.7 , Issue.5 , pp. 1429-1437
    • Lee, F.Y.1    Borzilleri, R.2    Fairchild, C.R.3
  • 23
    • 0029049468 scopus 로고
    • Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action
    • Bollag DM, McQueney PA, Zhu J et al.: Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Res. 55(11), 2325-2333 (1995).
    • (1995) Cancer Res , vol.55 , Issue.11 , pp. 2325-2333
    • Bollag, D.M.1    McQueney, P.A.2    Zhu, J.3
  • 24
    • 34047212584 scopus 로고    scopus 로고
    • Phase I study of the novel epothilone analog ixabepilone (BMS-247550) in patients with advanced solid tumors and lymphomas
    • Aghajanian C, Burris HA 3rd, Jones S et al.: Phase I study of the novel epothilone analog ixabepilone (BMS-247550) in patients with advanced solid tumors and lymphomas. J. Clin. Oncol. 25(9), 1082-1088 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.9 , pp. 1082-1088
    • Aghajanian, C.1    Burris 3rd, H.A.2    Jones, S.3
  • 25
    • 12144285977 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of BMS-247550, a novel derivative of epothilone B, in solid tumors
    • Mani S, McDaid H, Hamilton A et al.: Phase I clinical and pharmacokinetic study of BMS-247550, a novel derivative of epothilone B, in solid tumors. Clin. Cancer Res. 10(4), 1289-1298 (2004).
    • (2004) Clin. Cancer Res , vol.10 , Issue.4 , pp. 1289-1298
    • Mani, S.1    McDaid, H.2    Hamilton, A.3
  • 26
    • 24344450233 scopus 로고    scopus 로고
    • Phase I clinical trial of BMS-247550, a derivative of epothilone B, using accelerated titration 2B design
    • Gadgeel SM, Wozniak A, Boinpally RR et al.: Phase I clinical trial of BMS-247550, a derivative of epothilone B, using accelerated titration 2B design. Clin. Cancer Res. 11(17), 6233-6239 (2005).
    • (2005) Clin. Cancer Res , vol.11 , Issue.17 , pp. 6233-6239
    • Gadgeel, S.M.1    Wozniak, A.2    Boinpally, R.R.3
  • 27
    • 20244376916 scopus 로고    scopus 로고
    • A Phase I clinical trial of ixabepilone (BMS-247550), an epothilone B analog, administered intravenously on a daily schedule for 3 days
    • Zhuang SH, Agrawal M, Edgerly M et al.: A Phase I clinical trial of ixabepilone (BMS-247550), an epothilone B analog, administered intravenously on a daily schedule for 3 days. Cancer 103(9), 1932-1938 (2005).
    • (2005) Cancer , vol.103 , Issue.9 , pp. 1932-1938
    • Zhuang, S.H.1    Agrawal, M.2    Edgerly, M.3
  • 28
    • 0038811741 scopus 로고    scopus 로고
    • Phase I trial and pharmacokinetic study of BMS-247550, an epothilone B analog, administered intravenously on a daily schedule for five days
    • Abraham J, Agrawai M, Bakke S et al.: Phase I trial and pharmacokinetic study of BMS-247550, an epothilone B analog, administered intravenously on a daily schedule for five days. J. Clin. Oncol. 21(9), 1866-1873 (2003).
    • (2003) J. Clin. Oncol , vol.21 , Issue.9 , pp. 1866-1873
    • Abraham, J.1    Agrawai, M.2    Bakke, S.3
  • 29
    • 34248183039 scopus 로고    scopus 로고
    • Ixabepilone given weekly in patients with advanced malignancies: Final efficacy and safety results of a Phase I trial
    • Abstract 2040
    • Dickson N, Peck R, Wu C, Burris H: Ixabepilone given weekly in patients with advanced malignancies: final efficacy and safety results of a Phase I trial. J. Clin. Oncol. 24(S18) (2006) (Abstract 2040).
    • (2006) J. Clin. Oncol , Issue.S18 , pp. 24
    • Dickson, N.1    Peck, R.2    Wu, C.3    Burris, H.4
  • 30
    • 47249094258 scopus 로고    scopus 로고
    • A Phase I pharmacokinetic (PK) study of the epothilone B analogue, ixabepilone (BMS-247550) in patients (pts) with advanced malignancies and varying degrees of hepatic impairment. A SWOG Early Therapeutics Commitee and NCI Organ Dysfunction Working Group Trial
    • Abstract
    • Takimoto CH, Liu PY, Lenz H et al.: A Phase I pharmacokinetic (PK) study of the epothilone B analogue, ixabepilone (BMS-247550) in patients (pts) with advanced malignancies and varying degrees of hepatic impairment. A SWOG Early Therapeutics Commitee and NCI Organ Dysfunction Working Group Trial. J. Clin. Oncol. 24(S18) (2006) (Abstract 2004).
    • (2004) J. Clin. Oncol , Issue.S18 , pp. 24
    • Takimoto, C.H.1    Liu, P.Y.2    Lenz, H.3
  • 31
    • 34548157209 scopus 로고    scopus 로고
    • Efficacy and safety of ixabepilone (BMS-247550) in a Phase II study of patients with advanced breast cancer resistant to an anthracycline, a taxane, and capecitabine
    • Perez EA, Lerzo G, Pivot X et al.: Efficacy and safety of ixabepilone (BMS-247550) in a Phase II study of patients with advanced breast cancer resistant to an anthracycline, a taxane, and capecitabine. J. Clin. Oncol. 25(23), 3407-3414 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.23 , pp. 3407-3414
    • Perez, E.A.1    Lerzo, G.2    Pivot, X.3
  • 32
    • 34548187738 scopus 로고    scopus 로고
    • Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in patients with taxane-resistant metastatic breast cancer
    • Thomas E, Tabernero J, Fornier M et al.: Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in patients with taxane-resistant metastatic breast cancer. J. Clin. Oncol. 25(23), 3399-3406 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.23 , pp. 3399-3406
    • Thomas, E.1    Tabernero, J.2    Fornier, M.3
  • 33
    • 21044441003 scopus 로고    scopus 로고
    • Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in metastatic and locally advanced breast cancer
    • Low JA, Wedam SB, Lee JJ et al.: Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in metastatic and locally advanced breast cancer. J. Clin. Oncol. 23(12), 2726-2734 (2005).
    • (2005) J. Clin. Oncol , vol.23 , Issue.12 , pp. 2726-2734
    • Low, J.A.1    Wedam, S.B.2    Lee, J.J.3
  • 34
    • 34548179878 scopus 로고    scopus 로고
    • Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, as first-line therapy in patients with metastatic breast cancer previously treated with anthracycline chemotherapy
    • Roche H, Yelle L, Cognetti F et al.: Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, as first-line therapy in patients with metastatic breast cancer previously treated with anthracycline chemotherapy. J. Clin. Oncol. 25(23), 3415-3420 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.23 , pp. 3415-3420
    • Roche, H.1    Yelle, L.2    Cognetti, F.3
  • 35
    • 34548169630 scopus 로고    scopus 로고
    • Phase II trial of ixabepilone, an epothilone B analog, in patients with metastatic breast cancer previously untreated with taxanes
    • Denduluri N, Low JA, Lee JJ et al.: Phase II trial of ixabepilone, an epothilone B analog, in patients with metastatic breast cancer previously untreated with taxanes. J. Clin. Oncol. 25(23), 3421-3427 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.23 , pp. 3421-3427
    • Denduluri, N.1    Low, J.A.2    Lee, J.J.3
  • 36
    • 34247161458 scopus 로고    scopus 로고
    • Predicting response to ixabepilone: Genomics study in patients receiving single agent ixabepilone as neoadjuvant treatment for breast cancer (BC)
    • Presented at:, San Antonio, TX, USA, 8-11 December, Abstract 305
    • Baselga J, Gianni L, Llombart A et al.: Predicting response to ixabepilone: genomics study in patients receiving single agent ixabepilone as neoadjuvant treatment for breast cancer (BC). Presented at: San Antonio Breast Cancer Symposium. San Antonio, TX, USA, 8-11 December 2005 (Abstract 305).
    • (2005) San Antonio Breast Cancer Symposium
    • Baselga, J.1    Gianni, L.2    Llombart, A.3
  • 37
    • 34247848547 scopus 로고    scopus 로고
    • Final efficacy results of a Phase I/II trial of ixabepilone in combination with capecitabine in patients with metastatic breast cancer (MBC) previously treated with a taxane and anthracycline
    • Abstract 10511
    • Bunnell C, Klimovsky J, Thomas E: Final efficacy results of a Phase I/II trial of ixabepilone in combination with capecitabine in patients with metastatic breast cancer (MBC) previously treated with a taxane and anthracycline. J. Clin. Oncol. 24(S18) (2006) (Abstract 10511).
    • (2006) J. Clin. Oncol , Issue.S18 , pp. 24
    • Bunnell, C.1    Klimovsky, J.2    Thomas, E.3
  • 38
    • 36849071808 scopus 로고    scopus 로고
    • Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment
    • Thomas ES, Gomez HL, Li RK et al.: Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment. J. Clin. Oncol. 25(33), 5210-5217 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.33 , pp. 5210-5217
    • Thomas, E.S.1    Gomez, H.L.2    Li, R.K.3
  • 39
    • 84928590219 scopus 로고    scopus 로고
    • +) metastatic breast cancer (MBC). A trial coordinated by the Eastern Cooperative Oncology Group (E2103)
    • Atlanta, GA, USA, 2-6 June, Abstract 152
    • +) metastatic breast cancer (MBC). A trial coordinated by the Eastern Cooperative Oncology Group (E2103). 42nd ASCO Annual Meeting. Atlanta, GA, USA, 2-6 June, 2006 (Abstract 152).
    • (2006) 42nd ASCO Annual Meeting
    • Moulder, S.L.1    Wang, M.2    Gradishar3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.