Cyclobranol: A substrate for C25-methyl sterol side chains and potent mechanism-based inactivator of plant sterol methyltransferase

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 14, 2008, Pages 3878-3881

  Wang, Junqing ^a   Nes, W David ^a  

^a TEXAS TECH UNIVERSITY   (United States)

Author keywords

Cycloartenol; Cyclobranol; Mechanism based inhibitor; Phytosterol; Sterol C methylation; Sterol C24 methyltransferase

Indexed keywords

CYCLOBRANOL; METHYLTRANSFERASE INHIBITOR; PHYTOSTEROL;

ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME SUBSTRATE; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE;

BINDING SITES; CATALYSIS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENZYMES; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; METHYLATION; METHYLTRANSFERASES; MODELS, CHEMICAL; PHYTOSTEROLS; SOYBEANS; STEROLS; SUBSTRATE SPECIFICITY; TRITERPENES;

GLYCINE MAX;

EID: 47149100858     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.06.044     Document Type: Article

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19. 1H NMR signals for this compound in agreement with that shown in
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21. The standard assays for generating kinetic constants and for product determination were as described in Ref. 2.
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