Inactivation of soybean sterol 24-C-methyltransferase by elongated sterol side chains at C26

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 21, 2007, Pages 5902-5906

  Song, Zhihong ^a   Nes, W David ^a  

^a TEXAS TECH UNIVERSITY   (United States)

Author keywords

Cycloartenol; Mechanism based inhibitor; Phytosterol; Sterol methylation; Sterol methyltransferase

Indexed keywords

ALKENE DERIVATIVE; CYCLOARTENOL DERIVATIVE; METHYLTRANSFERASE; STEROL 24 C METHYLTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL BINDING; CHROMATOGRAPHY; DOSE TIME EFFECT RELATION; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ENZYME STRUCTURE; INHIBITION KINETICS; METHYLATION; NONHUMAN; REACTION ANALYSIS; SOYBEAN; STRUCTURE ACTIVITY RELATION;

AFFINITY LABELS; CHROMATOGRAPHY, GAS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROPHORESIS, POLYACRYLAMIDE GEL; KINETICS; METHYLTRANSFERASES; SOYBEANS; SUBSTRATE SPECIFICITY;

GLYCINE MAX;

EID: 34548851972     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.07.096     Document Type: Article

References (16)

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12. 1H NMR spectra of the inhibitors CA-8 and CA-14 were consistent with the structure assigned (cf. Refs. 6 and 7).
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14. -1. Using radio-HPLC to monitor for enzyme-generated product formation of assay with CA-8 or CA-14, only one monol C24-methylated product was detected.
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