In vitro and in vivo modulation of the equine immune response by parapoxvirus ovis

Equine Veterinary Journal

Volumn 40, Issue 5, 2008, Pages 468-472

  Horohov, D W ^a   Breathnach, C C ^a   Sturgill, T L ^a   Rashid, C ^a   Stiltner, J L ^a   Strong, D ^a   Nieman, N ^b   Holland, R E ^c  

^a UNIVERSITY OF KENTUCKY   (United States)

^b WinStar Farm   (United States)

^c ZOETIS   (United States)

Author keywords

Cytokine; Foal; Horse; Immunomodulator; Real time PCR

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CONCANAVALIN A; GAMMA INTERFERON; INTERLEUKIN 18; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ANIMAL DISEASE; ARTICLE; BIOSYNTHESIS; BLOOD; CELL CULTURE; GENETICS; HORSE; HORSE DISEASE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MONONUCLEAR CELL; PARAPOXVIRUS; POXVIRUS INFECTION; UPREGULATION;

ANIMALS; CELLS, CULTURED; CONCANAVALIN A; HORSE DISEASES; HORSES; INTERFERON TYPE II; INTERFERON-ALPHA; INTERFERON-BETA; INTERLEUKIN-18; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; PARAPOXVIRUS; POXVIRIDAE INFECTIONS; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EQUIDAE; ORF VIRUS; OVIS; OVIS ARIES; PARAPOXVIRUS; POXVIRIDAE;

EID: 47049131735     PISSN: 04251644     EISSN: None     Source Type: Journal    
DOI: 10.2746/042516408X322111     Document Type: Article

References (12)

1. Berenson, L.S., Ota, N. and Murphy, K.M. (2004) Issues in T-helper 1 development - resolved and unresolved. Immunolog. Rev. 202, 157-174.
2. Fachinger, V., Schlapp, T., Strube, W., Schmeer, N. and Saalmuller, A. (2000) Poxvirus-induced immunostimulating effects on porcine leukocytes. J. Virol. 74, 7943-7951.
3. Friebe, A., Siegling, A., Friederichs, S., Volk, H.D. and Weber, O. (2004) Immunomodulatory effects of inactivated parapoxvirus ovis (ORF virus) on human peripheral immune cells: induction of cytokine secretion in monocytes and Th1-like cells. J. Virol. 78, 9400-9411.
4. Giri, J.G., Anderson, D.M., Kumaki, S., Park, L.S., Grabstein, K.H. and Cosman, D. (1995) IL-15, a novel T cell growth factor that shares activities and receptor components with IL-2. J. leukocyte Biol. 57, 763-766.
5. Haig, D.M. and McInnes, C.J. (2002) Immunity and counter-immunity during infection with the parapoxvirus orf virus. Virus Res. 88, 3-16.
6. Hehlgans, T. and Pfeffer, K. (2005) The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games. Immunol. 115, 1-20.
7. Livak, K.J. and Schmittgen, T.D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(Delta Delta C(T)) method. Methods 25, 402-408.
8. Mayr, A. (2003) Development of a non-immunising, paraspecific vaccine from attenuated pox viruses: a new type of vaccine. New Microbiol. 26, 7-12.
9. Ohteki, T. (2002) Critical role for IL-15 in innate immunity. Curr. mol. Med. 2, 371-380.
10. Roach, D.R., Bean, A.G., Demangel, C., France, M.P., Briscoe, H. and Britton, W.J. (2002) TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection. J. Immunol. 168, 4620-4627.
11. Weber, O., Siegling, A., Friebe, A., Limmer, A., Schlapp, T., Knolle, P., Mercer, A., Schaller, H. and Volk, H.D. (2003) Inactivated parapoxvirus ovis (Orf virus) has antiviral activity against hepatitis B virus and herpes simplex virus. J. Gen. Virol. 84, 1843-1852.
12. Ziebell, K.L., Kretzdorn, D., Auer, S., Failing, K. and Schmeer, N. (1997) The use of Baypamun N in crowding-associated infectious respiratory disease: efficacy of Baypamun N (freeze dried product) in 2-week-old veal calves. Zentr. Vet. B 44, 415-424.