The serine protease motif of Pic mediates a dose-dependent mucolytic activity after binding to sugar constituents of the mucin substrate

Microbial Pathogenesis

Volumn 45, Issue 2, 2008, Pages 115-123

  Gutiérrez Jiménez, Javier ^a   Arciniega, Ivonne ^a   Navarro García, Fernando ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

Autotransporter protein; Lectin activity; Mucin; Mucinase; Pic; Proteolytic activity

Indexed keywords

BACTERIAL ENZYME; ENZYME VARIANT; FODRIN; HEMAGGLUTININ; HYALURONIDASE; IMMUNOGLOBULIN A; LACTOFERRIN; LECTIN; LYSOZYME; MONOSACCHARIDE; MUCIN; OLIGOSACCHARIDE; PROTEIN PIC; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; SUGAR;

ARTICLE; BACTERIAL COLONIZATION; BINDING COMPETITION; CELL DAMAGE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME RELEASE; ENZYME SUBSTRATE COMPLEX; HOST RESISTANCE; HUMAN; HUMAN CELL; INTESTINE; INTESTINE EPITHELIUM CELL; INTESTINE MUCOSA; MUCOLYSIS; MUCUS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MOTIF; SOLID;

BACTERIAL PROTEINS; BACTERIAL TOXINS; CARBOHYDRATES; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; MUCINS; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SUBSTRATE SPECIFICITY;

ESCHERICHIA COLI; SHIGELLA FLEXNERI;

EID: 47049125726     PISSN: 08824010     EISSN: 10961208     Source Type: Journal    
DOI: 10.1016/j.micpath.2008.04.006     Document Type: Article

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