Oligodendrocyte-specific protein is encephalitogenic in rhesus macaques and induces specific demyelination of the optic nerve

European Journal of Immunology

Volumn 38, Issue 5, 2008, Pages 1452-1464

  Bajramovic, Jeffrey J ^a   Brok, Herbert P M ^a   Ouwerling, Boudewijn ^a   Jagesar, S Anwar ^a   van Straalen, Linda ^a   Kondova, Ivanela ^a   Bauer, Jan ^b   Amor, Sandra ^a   t'Hart, Bert A ^a   Ben Nun, Avraham ^c  

^a BIOMEDICAL PRIMATE RESEARCH CENTRE   (Netherlands)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Animal models; Autoimmunity; Immunopathology; Neuroimmunology

Indexed keywords

CLAUDIN 11; CLDN11 PROTEIN, HUMAN; CYTOKINE; EPITOPE; NERVE PROTEIN; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; AUTOIMMUNITY; CELL PROLIFERATION; CONTROLLED STUDY; DEMYELINATION; DISEASE ASSOCIATION; FEMALE; HISTOPATHOLOGY; IMMUNIZATION; IMMUNOREACTIVITY; MULTIPLE SCLEROSIS; NEUROPATHOLOGY; NEUTROPHIL; NONHUMAN; NUCLEOTIDE SEQUENCE; OPTIC NEURITIS; PRIORITY JOURNAL; RHESUS MONKEY; RISK FACTOR; AMINO ACID SEQUENCE; ANIMAL; ANTIBODY PRODUCTION; BLINDNESS; CENTRAL NERVOUS SYSTEM; CYTOLOGY; DEMYELINATING DISEASE; GENETICS; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MACACA; METABOLISM; MOLECULAR GENETICS; MONONUCLEAR CELL; OPTIC NERVE; PATHOLOGY; SEQUENCE HOMOLOGY; SPLEEN; T LYMPHOCYTE; VACCINATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODY FORMATION; BLINDNESS; CENTRAL NERVOUS SYSTEM; CYTOKINES; DEMYELINATING DISEASES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; EPITOPES, B-LYMPHOCYTE; EPITOPES, T-LYMPHOCYTE; FEMALE; HUMANS; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MACACA MULATTA; MOLECULAR SEQUENCE DATA; MULTIPLE SCLEROSIS; NERVE TISSUE PROTEINS; OPTIC NERVE; PEPTIDE FRAGMENTS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SPLEEN; T-LYMPHOCYTES; VACCINATION;

EID: 47049119967     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200737164     Document Type: Article

References (34)

1. Bruck, W., The pathology of multiple sclerosis is the result of focal inflammatory demyelination with axonal damage. J. Neurol. 2005. 252 Suppl 5: V3-9.
2. Sospedra, M. and Martin, R., Immunology of multiple sclerosis. Annu. Rev. Immunol. 2005. 23: 60-747.
3. Ota, K., Matsui, M., Milford, E. L., Mackin, G. A., Weiner, H. L. and Hafler, D. A., T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature 1990. 346: 183-187.
4. Zhang, J., Weiner, H. L. and Hafler, D. A., Autoreactive T cells in multiple sclerosis. Int. Rev. Immunol. 1992. 9: 181-201.
5. Markovic-Plese, S., Fukaura, H., Zhang, J., al-Sabbagh, A., Southwood, S., Sette, A., Kuchroo, V. K. and Hafler, D. A., T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans. J. Immunol. 1995. 155: 982-992.
6. Sun, J. B., Olsson, T., Wang, W. Z., Xiao, B. G., Kostulas, V., Fredrikson, S., Ekre, H. P. and Link, H., Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls. Eur. J. Immunol. 1991. 21: 1461-1468.
7. Amor, S., Baker, D., Groome, N. and Turk J. L., Identification of a major encephalitogenic epitope of proteolipid protein (residues 56-70) for the induction of experimental allergic encephalomyelitis in Biozzi AB/H and nonobese diabetic mice. J. Immunol. 1993. 150: 5666-5672.
8. Sun, J., Link, H., Olsson, T., Xiao, B. G., Andersson, G., Ekre, H. P., Linington, C. and Diener, P., T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis. J. Immunol. 1991. 146: 1490-1495.
9. Johnson, D., Hafler, D. A., Fallis, R. J., Lees, M. B., Brady, R. O., Quarles, R. H. and Weiner, H. L., Cell-mediated immunity to myelin-associated glycoprotein, proteolipid protein, and myelin basic protein in multiple sclerosis. J. Neuroimmunol. 1986. 13: 99-108.
10. Zhang, Y., Burger, D., Saruhan, G., Jeannet, M. and Steck, A. J., The T-lymphocyte response against myelin-associated glycoprotein and myelin basic protein in patients with multiple sclerosis. Neurology 1993. 43: 403-407.
11. Bronstein, J. M., Lallone, R. L., Seitz, R. S., Ellison, G. W. and Myers, L W., A humoral response to oligodendrocyte-specific protein in MS: A potential molecular mimic. Neurology 1999. 53: 154-161.
12. Vu, T., Myers, L. W., Ellison, G. W., Mendoza, F. and Bronstein, J. M., T-cell responses to oligodendrocyte-specific protein in multiple sclerosis. J. Neurosci. Res. 2001. 66: 506-509.
13. van Noort, J. M., van Sechel, A. C., Bajramovic, J. J., el Ouaginiri, M., Polman, C. H., Lassmann, H. and Ravid, R., The small heat-shock protein alpha B-crystallin as candidate autoantingen in multiple sclerosis. Nature 1995. 375: 798-801.
14. Ousman, S. S., Tomooka, B. H., van Noort, J. M., Wawrousek, E. F., O'Conner, K., Hafler, D. A., Sobel, R. A. et al., Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination. Nature 2007. 448: 474-479.
15. Bronstein, J. M., Micevych, P. E. and Chen, K., Oligodendrocyte-specific protein (OSP) is a major component of CNS myelin. J. Neurosci Res. 1997. 50: 713-720.
16. Bronstein, J. M., Popper, P., Micevych, P. E. and Farber, D. B., Isolation and characterization of a novel oligodendrocyte-specific protein. Neurology 1996. 47: 772-778.
17. Bronstein, J. M., Tiwari-Woodruff, S., Buznikov, A. G. and Stevens, D. B., Involvement of OSP/claudin-11 in oligodendrocyte membrane interactions: Role in biology and disease. J. Neurosci. Res. 2000. 59: 706-711.
18. Bronstein, J. M., Function of tetraspan proteins in the myelin sheath. Curr. Opin. Neurobiol. 2000. 10: 552-557.
19. Bronstein, J. M., Chen, K., Tiwari-Woodruff, S. and Kornblum, H. I., Developmental expression of OSP/claudin-11. J. Neurosci. Res. 2000. 60: 284-290.
20. Tiwari-Woodruff, S. K., Buznikov, A. G., Vu, T. Q., Micevych, P. E., Chen, K., Kornblum, H. I. and Bronstein, J. M., OSP/claudin-11 forms a complex with a novel member of the tetraspanin super family and beta1 integrin and regulates proliferation and migration of oligodendrocytes. J. Cell Biol. 2001. 153: 295-305.
21. Tiwari-Woodruff, S. K., Kaplan, R., Kornblum, H. I. and Bronstein, J. M., Developmental expression of OAP-1/Tspan-3, a member of the tetraspanin superfamily. J. Neurosci. Res. 2004. 77: 166-173.
22. Kaushansky, N., Zhong, M. C., Kerlero de Rosbo, N., Hoeftberger, R., Lassmann, H. and Ben-Nun, A., Epitope specificity of autoreactive T and B cells associated with experimental autoimmune encephalomyelitis and optic neuritis induced by oligodendrocyte-specific protein in SJL,/J mice. J. Immunol. 2006. 177: 7364-7376.
23. Morris-Downes, M. M., McCormack, K., Baker, D., Sivaprasad, D., Natkunarajah, J. and Amor, S., Encephalitogenic and immunogenic potential of myelin-associated glycoprotein (MAG), oligodendrocyte-specific glycoprotein (OSP) and 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) in ABH and SJL mice. J. Neuroimmunol. 2002. 122: 20-33.
24. Stevens, D. B., Chen, K., Seitz, R. S., Sercarz, E. E. and Bronstein, J. M., Oligodendrocyte-specific protein peptides induce experimental autoimmune encephalomyelitis in SJL/J mice. J. Immunol. 1999. 162: 7501-7509.
25. Zhong, M. C., Cohen, L., Meshorer, A., Xerlero de Rosbo, N. and Ben-Nun, A., T-cells specific for soluble recombinant oligodendrocyte-specific protein induce severe clinical experimental autoimmune encephalomyelitis in H-2(b) and H-2(s) mice. J. Neuroimmunol. 2000. b 105: 39-45.
26. Kaushansky, N., Hemo, R., Eisenstein, M. and Ben-Nun, A., OSP/ claudin 11-induced EAE in mice is mediated by pathogenic T cells primarily governed by OSP192Y residue of major encephalitogenic region OSP179-207. Eur. J. Immunol. 2007. 37: 2018-2031.
27. Brok, H. P., Bauer, J., Jonker, M., Blezer, E., Amor, S., Bontrop, R. E., Laman, J. D. and t Hart, B. A., Non-human primate models of multiple sclerosis. Immunol. Rev. 2001. 183: 173-185.
28. Giavedoni, L. D., Simultaneous detection of multiple cytokines and chemokines from nonhuman primates using luminex technology. J. Immunol. Methods 2005. 301: 89-101.
29. Morita, K., Sasaki, H., Fujimoto, K., Furuse, M. and Tsukka, S., Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis. J. Cell Biol. 1999. 145: 579-588.
30. Gow, A., Southwood, C. M., Li, J. S., Pariali, M., Riordan, G. P., Brodie, S. E., Danias, J. et al., CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice. Cell 1999. 99: 649-659.
31. Bettelli, E., Pagany, M., Weiner, H. L., Linington, C., Sobel, R. A. and Kuchroo, V. K., Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J. Exp. Med. 2003. 197: 1073-1081.
32. Shao, H., Huang, Z., Sun, S. L., Kaplan, H. J. and Sun, D., Myelin/oligodendrocyte glycoprotein-specific T-cells induce severe optic neuritis in the CS7BL/6 mouse. Invest. Ophthalmol. Vis. Sci. 2004. 45: 4060-4065.
33. Frohman, E. M., Frohman, T. C., Zee, D. S., McColl, R. and Galetta, S., The neuro-ophthalmology of multiple sclerosis. Lancet Neurol. 2005. 4: 111-121.
34. Miller, D., Barkhof, F., Montalban, X., Thompson, A. and Filippi, M., Clinically isolated syndromes suggestive of multiple sclerosis, part I: Natural history, pathogenesis, diagnosis, and prognosis. Lancet Neurol. 2005. 4: 281-288.