Renin/prorenin receptor, (P)RR, in end-organ damage: current issues in 2007

Journal of the American Society of Hypertension

Volumn 2, Issue 4, 2008, Pages 205-209

  Inagami, Tadashi ^a   Nakagawa, Tsutomu ^a   Ichihara, Atsuhiro ^b   Suzuki, Fumiaki ^c   Itoh, Hiroshi ^b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KEIO UNIVERSITY   (Japan)

^c GIFU UNIVERSITY   (Japan)

Author keywords

hypertension; Receptor blocker; streptozotocin diabetes mellitus

Indexed keywords

ANGIOTENSIN II; GLUCOSE; PRORENIN; RENIN; RENIN INHIBITOR;

AGING; BLOOD PRESSURE MEASUREMENT; CARDIOMYOPATHY; CONCENTRATION (PARAMETERS); DIABETES MELLITUS; DIABETIC NEPHROPATHY; GENE OVEREXPRESSION; GLUCOSE BLOOD LEVEL; HUMAN; HYPERTENSION; IN VIVO STUDY; KIDNEY DISEASE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEGRADATION; RECEPTOR UPREGULATION; REVIEW; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; TRANSGENIC RAT; TREATMENT OUTCOME;

EID: 47049102213     PISSN: 19331711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jash.2007.12.006     Document Type: Review

References (18)

1. Nguyen G., Delarue F., Berrou J., Rondeau E., and Sraer J.D. Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen. Kidney Int 50 (1996) 1897-1903
2. Nguyen G., Delarue F., Burckle C., Bouzhir L., Giller T., and Sraer J.D. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 109 (2002) 1417-1427
3. Suzuki F., Hayakawa M., Nakagawa T., Nasir U.M., Ebihara A., Iwasawa A., et al. Human prorenin has "gate and handle" regions for its non-proteolytic activation. J Biol Chem 278 (2003) 22217-22222
4. Nabi A.H., Uddin M., Nakagawa T., Iwata H., Ichihara A., Inagami T., et al. Role of "handle" region of prorenin prosegment in the non-proteolytic activation of prorenin by binding to membrane anchored (pro)renin receptor. Front Biosci 12 (2007) 4810-4817
5. Ichihara A., Hayashi M., Kaneshiro Y., Suzuki F., Nakagawa T., Tada Y., et al. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for non-proteolytic activation of prorenin. J Clin Invest 114 (2004) 1128-1135
6. Danser A.H.J., and Denium J. Renin, prorenin and putative (Pro)renin receptor. Hypertension 46 (2005) 1069-1076
7. Kaneshiro Y., Ichihara A., Takemitsu T., Sakoda M., Suzuki F., Nakagawa T., et al. Increased expression of cyclooxygenase-2 in renal cortex of human-prorenin-receptor-gene transgenic rats. Kidney Int 70 (2006) 641-646
8. Saris J.J., 'tHoen P.A., Garrelds I.M., Dekkers D.H., den Dunnen J.T., Lamers J.M., et al. Prorenin induces intracellular signaling in cardiomyocytes independently of angiotensin II. Hypertension 48 (2006) 564-571
9. Huang Y., Wongamorntham S., Kasting J., McQuillan D., Owens R.T., Yu L., et al. Renin increases mesangial cell transforming growth factor-β1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms. Kidney Int 69 (2006) 105-113
10. Huang Y., Noble N., Zhang J., Xu C., and Border W.A. Renin-stimulated TGF-beta1 expression is regulated by a mitogen-activated protein kinase in mesangial cells. Kidney Int 72 (2007) 45-52
11. Ichihara A., Suzuki F., Nakagawa T., Kaneshiro Y., Takemitsu T., Sakoda M., et al. Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor deficient mice. J Am Soc Nephrol 17 (2006) 1950-1961
12. Ichihara A., Kaneshiro Y., Takemitsu T., Sakoda M., Nakagawa T., Nishiyama A., et al. Contribution of non-proteolytically activated prorenin in glomeruli to hypertensive renal damage. J Am Soc Nephrol 17 (2006) 2495-2503
13. Susic D., Lippton H., Knight M., and Frolich E. Cardiovascular effects of nonproteolytic activation of prorenin. Hypertension 48 (2006) e113
14. Ichihara A., Kaneshiro Y., Takemitsu T., Sakoda M., Suzuki F., Nakagawa T., et al. Non-proteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension. Hypertension 47 (2006) 894-900
15. Kaneshiro Y., Ichihara A., Sakoda M., Takemitsu T., Nabi A.H., Uddin M.N., et al. Slowly progressive, angiotensin II-independent glomerulosclerosis in human-renin/prorenin-receptor-transgenic rats. J Am Soc Nephrol 18 (2007) 1789-1795
16. Burckle C.A., Danser J.A.H., Muller D.N., Garrelds I.M., Gasc J.M., Popova E., et al. Elevated blood pressure and heart rate in human renin receptor transgenic rats. Hypertension 47 (2006) 552-556
17. Veniant M., Menard J., Bruneval P., Morley S., Gonzales M.F., and Mullins J. Vascular damage without hypertension in transgenic rats expressing prorenin exclusively in the liver. J Clin Invest 98 (1996) 1966-1970
18. Nabi A.H.M.N., Kageshima A., Uddin M., Nakagawa T., Park E.Y., and Suzuki F. Binding properties of rat prorenin and renin to the recombinant rat renin/prorenin receptor prepared by a baculovirus expression system. Int J Mol Med 18 (2006) 483-488