Postnatal Sepsis, Necrotizing Entercolitis, and the Critical Role of Systemic Inflammation in White Matter Injury in Premature Infants

Journal of Pediatrics

Volumn 153, Issue 2, 2008, Pages 160-163

  Volpe, Joseph J ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; CYTOKINE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANTIBIOTIC THERAPY; BEHAVIOR DISORDER; BIRTH WEIGHT; BRAIN INJURY; COGNITIVE DEFECT; CYTOKINE RELEASE; DISABILITY; EDITORIAL; ELECTROENCEPHALOGRAPHY; ENCEPHALITIS; ENCEPHALOMALACIA; EXCITOTOXICITY; HUMAN; INCIDENCE; INNATE IMMUNITY; NECROTIZING ENTEROCOLITIS; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PATHOGENESIS; PERINATAL PERIOD; PREMATURITY; PRIORITY JOURNAL; PROTEIN FUNCTION; SEPSIS; WHITE MATTER;

DEVELOPMENTAL DISABILITIES; ENTEROCOLITIS, NECROTIZING; GENE EXPRESSION; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE, DISEASES; INFLAMMATION; LEUKOMALACIA, PERIVENTRICULAR; SEPSIS; TOLL-LIKE RECEPTORS;

EID: 47049096025     PISSN: 00223476     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpeds.2008.04.057     Document Type: Editorial

References (40)

1. Volpe J.J. Neurology of the Newborn. 5th edition (2008), Elsevier, Philadelphia
2. Pierson C.R., Folkerth R.D., Billards S.S., Trachtenberg F.L., Drinkwater M.E., Volpe J.J., et al. Gray matter injury associated with periventricular leukomalacia in the premature infant. Acta Neuropathol 114 (2007) 619-631
3. Shah D.K., Doyle L.W., Anderson P.J., Bear M., Daley A.J., Hunt R.W., et al. Adverse neurodevelopment in preterm infants with postnatal sepsis or necrotizing enterocolitis is mediated by white matter abnormality on magnetic resonance imaging at term. J Pediatr 153 (2008) 170-175
4. Stoll B.J., Hansen N., Fanaroff A.A., Wright L.L., Carlo W.A., Ehrenkranz R.A., et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 110 (2002) 285-291
5. Bizzarro M.J., Raskind C., Baltimore R.S., and Gallagher P.G. Seventy-five years of neonatal sepsis at Yale, 1928-2003. Pediatrics 116 (2005) 595-602
6. Stoll B.J., Hansen N., Fanaroff A.A., Wright L.L., Carlo W.A., Ehrenkranz R.A., et al. Changes in pathogens causing early-onset sepsis in very low birth weight infants. N Engl J Med 347 (2002) 240-247
7. Makhoul I.R., Sujov P., Smolkin T., Lusky A., and Reichman B. Pathogen-specific early mortality in very low birth weight infants with late-onset sepsis: a national survey. Clin Infect Dis 40 (2005) 218-224
8. Adams-Chapman I., and Stoll B.J. Neonatal infection and long-term neurodevelopmental outcome in the preterm infant. Curr Opin Infect Dis 19 (2006) 290-297
9. Hintz S.R., Kendrick D.E., Stoll B.J., Vohr B.R., Fanaroff A.A., Donovan E.F., et al. Neurodevelopmental and growth outcomes of extremely low birth weight infants after necrotizing enterocolitis. Pediatrics 115 (2005) 696-703
10. Salhab W.A., Perlman J.M., Silver L., and Broyles R.S. Necrotizing enterocolitis and neurodevelopmental outcome in extremely low birth weight infants <1000 g. J Perinatol 24 (2004) 534-540
11. Stoll B.J., Hansen N.I., Adams Chapman I., Fanaroff A.A., Hintz S.R., Vohr B., et al. Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection. JAMA 292 (2004) 2357-2365
12. Woodward L.J., Anderson P.J., Austin N.C., Howard K., and Inder T.E. Neonatal MRI to predict neurodevelopmental outcomes in preterm infants. N Eng J Med 355 (2006) 685-694
13. Gilles F.H., Leviton A., and Dooling E.C. The Developing Human Brain: Growth and Epidemiologic Neuropathology (1983), John Wright, Boston
14. Dammann O., and Leviton A. Inflammatory brain damage in preterm newborns: dry numbers, wet lab, and causal inferences. Early Hum Dev 79 (2004) 1-15
15. Edwards A.D., and Tan S. Perinatal infections, prematurity and brain injury. Curr Opin Pediatr 18 (2006) 119-124
16. Khwaja O., and Volpe J.J. Pathogenesis of cerebral white matter injury of prematurity. Arch Dis Child Fetal Neonatal Ed 93 (2008) F153-F161
17. Haynes R.L., Abaud O., Li J., Kinney H.C., Voklpe J.J., and Folkerth R.D. Oxidative and nitrative injury in periventricular leukomalacia: a review. Brain Pathol 15 (2005) 225-233
18. Kadhim H.J., Tabarki B., Verellen G., De Prez C., Rona A.M., and Sebire G. Inflammatory cytokines in the pathogenesis of periventricular leukomalacia. Neurology 56 (2001) 1278-1284
19. Matute C., Alberdi E., Domercq M., Sanchez-Gomez M.V., Perez-Samartin A., Rodriguez-Antiguedad A., et al. Excitotoxic damage to white matter. J Anat 210 (2007) 693-702
20. Billiards S.S., Haynes R.L., Folkerth R.D., Trachtenberg F.L., Liu L.G., Volpe J.J., et al. Development of microglia in the cerebral white matter of the human fetus and infant. J Comp Neurol 497 (2006) 199-208
21. Soul J.S., Hammer P.E., Tsuji M., Saul P., Bassan H., Limperopoulos C., et al. Fluctuating pressure-passivity is common in the cerebral circulation of sick premature infants. Pediatr Res 61 (2007) 467-473
22. Yanowitz T.D., Potter D.M., Bowen A., Baker R.W., and Roberts J.M. Variability in cerebral oxygen delivery is reduced in premature neonates exposed to chorioamnionitis. Pediatr Res 59 (2006) 299-304
23. Sharma R., Tepas III J.J., Hudak M.L., Mollitt D.L., Wludyka P.S., Teng R.J., et al. Neonatal gut barrier and multiple organ failure: role of endotoxin and proinflammatory cytokines in sepsis and necrotizing enterocolitis. J Pediatr Surg 42 (2007) 454-461
24. Eklind S., Mallard C., Leverin A.L., Gilland E., Blomgren K., Mattsby-Baltzer I., et al. Bacterial endotoxin sensitizes the immature brain to hypoxic-ischaemic injury. Eur J Neurosci 13 (2001) 1101-1106
25. Lehnardt S., Massillon L., Follet P., Jensen F.E., Ratan R.R., Rosenberg P.A., et al. Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway. Proc Natl Acad Sci U S A (2003) 8514-8519
26. Ikeda T., Mishima K., Aoo N., Egashira N., Iwasaki K., Fujiwara M., et al. Combination treatment of neonatal rats with hypoxia-ischemia and endotoxin induces long-lasting memory and learning impairment that is associated with extended cerebral damage. Am J Obstet Gynecol 191 (2004) 2132-2141
27. Larouche A., Roy M., Kadhim H., Tsanaclis A.M., Fortin D., and Sebire G. Neuronal injuries induced by perinatal hypoxic-ischemic insults are potentiated by prenatal exposure to lipopolysaccharide: animal model for perinatally acquired encephalopathy. Dev Neurosci 27 (2005) 134-142
28. Wang X., Hagberg H., Nie C., Zhu C., Ikeda T., and Mallard C. Dual role of intrauterine immune challenge on neonatal and adult brain vulnerability to hypoxia-ischemia. J Neuropathol Exp Neurol 66 (2007) 552-561
29. Eklind S., Hagberg H., Wang X., Savman K., Leverin A.L., Hedtjarn M., et al. Effect of lipopolysaccharide on global gene expression in the immature rat brain. Pediatr Res 60 (2006) 161-168
30. Hagberg H., and Mallard C. Effect of inflammation on central nervous system development and vulnerability. Curr Opin Neurol 18 (2005) 117-123
31. Fleer A., and Krediet T.G. Innate immunity: Toll-like receptors and some more. A brief history, basic organization and relevance for the human newborn. Neonatology 92 (2007) 145-157
32. Lehnardt S., Lachance C., Patrizi S., Lefebvre S., Follett P.L., Jensen F.E., et al. The Toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS. J Neurosci 22 (2002) 2478-2486
33. Lehnardt S., Henneke P., Lien E., Kasper D.L., Volpe J.J., Bechmann I., et al. A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia. J Immunol 177 (2006) 583-592
34. Hoffmann O., Braun J.S., Becker D., Halle A., Freyer D., Dagand E., et al. TLR2 mediates neuroinflammation and neuronal damage. J Immunol 178 (2007) 6476-6481
35. Pachter J.S., De Vries H.E., and Fabry Z. The blood-brain barrier and its role in immune privilege in the central nervous system. J Neuropath Exp Neurol 62 (2003) 593-604
36. Chakravarty S., and Herkenham M. Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines. J Neurosci 25 (2005) 1788-1796
37. Stolp H.B., Ek C.J., Johansson P.A., Dziegielewska K.M., Potter A.M., Habgood M.D., et al. Effect of minocycline on inflammation-induced damage to the blood-brain barrier and white matter during development. Eur J Neurosci 26 (2007) 3465-3474
38. Miyake K. Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors. Semin Immunol 19 (2007) 3-10
39. Tang S.C., Arumugam T.V., Xu X., Cheng A., Mughal M.R., Jo D.G., et al. Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc Natl Acad Sci U S A 104 (2007) 13798-13803
40. Lehnardt S., Lehmann S., Kaul D., Tschimmel K., Hoffmann O., Cho S., et al. Toll-like receptor 2 mediates CNS injury in focal cerebral ischemia. J Neuroimmunol 190 (2007) 28-33