Buccal bioadhesive delivery system of 5-fluorouracil: Optimization and characterization

Drug Development and Industrial Pharmacy

Volumn 34, Issue 7, 2008, Pages 761-770

  Dhiman, Munish Kumar ^a   Yedurkar, Pramod D ^a   Sawant, Krutika K ^a  

^a M S UNIVERSITY OF BARODA   (India)

Author keywords

5 fluorouracil; Bioadhesive tablets; Contour plots; Factorial design; Gantrez; HPMC; Response surface methodology

Indexed keywords

FLUOROURACIL; GANTREZ COPOLYMER; HYDROXYPROPYLMETHYLCELLULOSE;

ARTICLE; COMPUTER PROGRAM; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG RELEASE; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; KINETICS; TABLET FORMULATION;

ADHESIVES; ADMINISTRATION, BUCCAL; ANTIMETABOLITES, ANTINEOPLASTIC; CALORIMETRY, DIFFERENTIAL SCANNING; DRUG INCOMPATIBILITY; DRUG SYNERGISM; EXCIPIENTS; FLUOROURACIL; KINETICS; MALEATES; METHYLCELLULOSE; POLYVINYLS; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TABLETS; TIME FACTORS;

EID: 46949094154     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.1080/03639040801926337     Document Type: Article

References (45)

1. Agrawal, V., & Mishra, B. (1999). Design, development and biopharmaceutical properties of buccoadhesive compacts of pentazocine. Drug Dev. Ind. Pharm., 25, 701-709.
2. Ahuja, A., Khar, R. K., & Ali, J. (1997). Mucoadhesive drug delivery. Drug Dev.Ind. Pharm., 23, 489-515.
3. Alur, H. H., Beal, J. D., Pather, S. I., Mitra, A. K., & Johnston, T. P. (1999). Evaluation of a novel, natural oligosaccharide gum as a sustained-release and mucoadhesive component of calcitonin buccal tablets. J. Pharm. Sci., 88, 1313-1319.
4. Attia, M. A., El Gibaly, I., Shaltout, S. E., & Fetih, G. N. (2004). Transbuccal permeation, anti-inflammatory activity and clinical efficacy of piroxicam formulated in different gels. Int. J. Pharm., 276, 11-28.
5. Benes, L., Claustrat, B., Horriere, F., Geoffriau, M., Konsil, J., Parrott, K. A., DeGrande, G., McQuinn, R. L., & Ayres, J. W. (1997). Transmucosal, oral controlled release, and transdermal drug administration in human subjects: A crossover study with melatonin. J. Pharm. Sci., 86, 1115-1119.
6. Bouckaert, S., Massart, D. L., Massart, B., & Rremon, J. P. (1996). Optimization of a granulation procedure for a hydrophilic matrix tablet design. Drug Dev. Ind. Pharm., 22, 321-327.
7. Chidambaram, N., & Srivastava, A. K. (1995). Buccal drug delivery systems. Drug Dev. Ind. Pharm., 21, 1009-1036.
8. Clas, D. S., Dalton, C. R., & Hancock, B. C. (1999). Differential scanning calorimetry: Applications in drug development. Pharm. Sci. Technol. Today, 2(8), 311-319.
9. Desai, K. G. H., & Kumar, T. M. P. (2004). Preparation and evaluation of a novel buccal adhesive system. AAPS Pharm. Sci. Technol., 5, article 35.
10. Diasio, R. B., & Harris, B. E. (1989). Clinical pharmacology of 5-fluorouracil. Clin. Pharmacokinet., 16, 215-237.
11. Dollery, C. (Ed.) (1999). Therapeutic drugs (2nd ed., Vol. 1, pp. F103-F108). Edinburgh: Churchill Livingstone.
12. Ford, J. L., Rubinstein, M. H., & Hogan, J. E. (1985). Formation of sustained release promethazine hydrochloride tablets using hydroxypropylmethylcellulose matrix. Int. J. Pharm., 24, 327-338.
13. Gantrez Brochure (2005). Wayne, NJ: International Speciality Products Ltd.
14. Hoogstraate, A. J., Verhoef, J. C., Tuk, B., Pijpers, A., Van Leengoed, L. A. M. G, Verheijden, J. H. M., Junginger, H. E., & Bodde, H. (1996). Buccal delivery of fluorescein isothiocyanate-dextran 4400 and the peptide drug buserelin with glycodeoxycholate as an absorption enhancer in pigs. J. Control. Release, 41(1-2), 77-84.
15. Hoogstraate, A. J., & Wertz, P. W. (1998). Drug delivery via the buccal mucosa. Pharm. Sci. Technol. Today, 1, 309-316.
16. Huang, Y. B., Tsai, Y. H., Lee, S. H., Chang, J. S., & Wu, P. C. (2005). Optimization of pH-independent release of nicardipine hydrochloride extended-release matrix tablets using response surface methodology. Int. J. Pharm., 289, (1-2), 87-95.
17. Huang, Y. B., Tsai, Y. H., Yang, W. C., Chang, J. S., & Wu, P. C. (2004). Optimization of sustained-release propranolol dosage form using factorial design and response surface methodology. Biol. Pharm. Bull., 27, 1626-1629.
18. Huang, Y. B., Tsai, Y. H., Yang, W. C., Chang, J. S., Wu, P. C., & Takayama, K. (2004). Once-daily propranolol extended-release tablet dosage form: Formulation design and in vitro/in vivo investigation. Eur. J. Pharm. Biopharm., 58, 607-614.
19. Jay, S., Fountain, W., Cui, Z., & Mumper, R. J. (2002). Transmucosal delivery of testosterone in rabbits using novel bi-layer mucoadhesive wax-film composite disks. J. Pharm. Sci., 91, 2016.
20. Jonnalagadda, S., & Robinson, D. H. (2000). A bioresorbable, polylactide reservoir for diffusional and osmotically controlled drug delivery. AAPS Pharm. Sci. Technol., 1(4), article 29.
21. Korsmeyer, R. W., Gurny, R., Doelker, E., Buri, P., & Peppas N. A. (1983). Mechanisms of solute release from porous hydrophilic polymers. Int. J. Pharm., 15, 25-35.
22. Lahdenpaa, E., Niskanen, M., & Yliruusi, J. (1997). Crushing strength, disintegration time and weight variation of tablets compressed from three avicel pH grades and their mixtures. Eur. J. Pharm. Biopharm., 42, 315-322.
23. Li, C., Bhatt, P. P., and Johnston, T. P. (1997). Transmucosal delivery of oxytocin to rabbits using a mucoadhesive buccal patch. Pharm. Dev. Technol., 2, 265-274.
24. Mehta, A. K., Yadav K. S., and Sawant, K. K. (2007). Nimodipine loaded PLGA nanoparticles: Formulation optimization using factorial design, characterization and in vitro evaluation. Curr. Drug Del., 4, 185-193.
25. Miyazaki, S., Kawasaki, N., Nakamura, T., Iwatsu, M., Hayashi, T., Hou, M., & Attwood, D. (2000). Oral mucosal bioadhesive tablets of pectin and HPMC: In vitro and in vivo evaluation. Int. J. Pharm., 204, 127-132.
26. Nafee, N. A., Ismail, F. A., Boraie, N. A., & Mortada, L. M. (2003). Mucoadhesive buccal patches of miconazole nitrate: In vitro/in vivo performance and effect of ageing. Int. J. Pharm., 264, 1-14.
27. Narendra, C., Srinath, M. S., & Prakash Rao, B. (2005). Development of three layered buccal compact containing metoprolol tartrate by statistical optimization technique. Int. J. Pharm., 304, 102-114.
28. Owens, T. S., Dansereau, R. J., & Sakr, A. (2005). Development and evaluation of extended release bioadhesive sodium fluoride tablets. Int. J. Pharm., 288, 109-122.
29. Patel, V. M., Prajapati, B. G., & Patel M. M. (2007). Effect of hydrophilic polymers on buccoadhesive eudragit patches of propranolol hydrochloride using factorial design. AAPS Pharm. Sci. Technol., 8(2), article 45.
30. Peppas, N. A. (1985). Analysis of Fickian and non-Fickian drug release from polymers. Pharm. Acta. Helv., 60, 110-111.
31. 3 factorial design. AAPS Pharm. Sci. Technol., 4(4), article 71.
32. Sako, K., Sawada, T., Nakashima, H., Yokohama, S., & Sonobe, T. (2002). Influence of water soluble fillers on hydroxypropylmethylcellulose matrix on in vitro and in vivo drug release. J. Control. Release, 81, 165-172.
33. Schechter, N. L., Weisman, S. J., Rosenblum, M., Bernstein, B., & Conard, P. L., (1995). The use of oral transmucosal fentanyl citrate for painful procedures in children. Pediatrics, 95, 335-339.
34. Schwagmeier, R., Alincic, S., & Striebel, H. W. (1998). Midazolam pharmacokinetics following intravenous and buccal administration. Br. J. Clin. Pharmacol., 46, 203-206.
35. Shin, S. C., Bum, J. P., & Choi, J. S. (2000). Enhanced bioavailability by buccal administration of triamcinolone acetonide from the bioadhesive gels in rabbits. Int. J. Pharm., 209, 37-43.
36. Shin, S. C., Cho, C. W., & Yang, K. H. (2004). Development of lidocaine gels for enhanced local anesthetic action. Int. J. Pharm., 287, 73-78.
37. Singh, B., & Ahuja, N. (2002). Development of controlled-release buccoadhesive hydrophilic matrices of diltiazem hydrochloride: Optimization of bioadhesion, dissolution, and diffusion parameters. Drug Dev. Ind. Pharm., 28, 431-442.
38. Singh, B., Chakkal, S. K., & Ahuja, N. (2006). Formulation and optimization of controlled release mucoadhesive tablets of atenolol using response surface methodology. AAPS Pharm. Sci. Tech., 7(1), article 3.
39. Singh, S. K., Dodge, J., Durrani, M. J., & Khan, M. (1995). Factorial design in the feasibility of producing microcel MC-101 pellets by extrusion spheronization. Int. J. Pharm., 115, 53-60.
40. Smart, J. D. (1993). Drug delivery using buccal-adhesive systems, Adv. Drug Del. Rev., 11, 1253-270.
41. Tsutsumi, K., Obata, Y., Nagai, T., Loftsson, T., & Takayama K. (2002). Buccal absorption of ergotamine tartrate using the bioadhesive tablet system in guinea-pigs, Int. J. Pharm., 238, 161-170.
42. Vandervoort, J., & Ludwig, A. (2001). Preparation factors affecting the properties of polylactide nanoparticles: A factorial design study. Pharmazie, 56, 484-488.
43. Varma, M., Singla, A. K., and Dhawan, S. (2004). Release of diltiazem hydrochloride from hydrophilic matrices of polyethylene oxide and carbopol. Drug Dev. Ind. Pharm., 30, 545-553.
44. Voorspoels, J., Remon, J. P., Eechaute, W., & De Sy. W. (1996). Buccal absorption of testosterone and its esters using a bioadhesive tablet in dogs. Pharm. Res., 13, 1228-1232.
45. Zuleger, S., & Lippold, B. C. (2001). Polymer particle erosion controlling drug release: I. Factors influencing drug release and characterization of the release mechanism. Int. J. Pharm., 217, 139-152.