Development of nitrendipine controlled release formulations based on SLN and NLC for topical delivery: In vitro and ex vivo characterization

Drug Development and Industrial Pharmacy

Volumn 34, Issue 7, 2008, Pages 719-725

  Bhaskar, Kesavan ^a,b   Krishna Mohan, Chinnala ^a   Lingam, Meka ^a   Prabhakar Reddy, Veerareddy ^a   Venkateswarlu, Vobalaboina ^a   Madhusudan Rao, Yamsani ^a  

^a KAKATIYA UNIVERSITY   (India)

^b VELS INSTITUTE OF SCIENCE   (India)

Author keywords

Drug release; Nanostructure lipid carriers; Nitrendipine; NLC; Skin permeation; SLN; Solid lipid nanoparticles

Indexed keywords

NANOMATERIAL; NITRENDIPINE; SOLID LIPID NANOPARTICLE;

ABDOMEN; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG FORMULATION; DRUG PENETRATION; DRUG RELEASE; DRUG STABILITY; DRUG STORAGE; DRUG SYNTHESIS; EX VIVO STUDY; IN VITRO STUDY; KINETICS; MALE; NONHUMAN; PARTICLE SIZE; PHOTON CORRELATION SPECTROSCOPY; RAT; ROOM TEMPERATURE; SKIN; STEADY STATE; ULTRASOUND; ZETA POTENTIAL;

ADMINISTRATION, CUTANEOUS; ANIMALS; CALCIUM CHANNEL BLOCKERS; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DIFFUSION; DRUG STABILITY; DRUG STORAGE; KINETICS; LIPIDS; MALE; NANOPARTICLES; NITRENDIPINE; PARTICLE SIZE; PERMEABILITY; RATS; RATS, WISTAR; SKIN ABSORPTION; SONICATION;

EID: 46949090798     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.1080/03639040701842485     Document Type: Article

References (22)

1. Abubakr, O., & Jun, S. Z. (2000). Captopril floating and/or bioadhesive tablets: Design and release kinetics. Drug Dev. Ind. Pharm., 26, 965-969.
2. Bunjes, H., & Westesen, K. (1995). Do nanoparticles prepared from lipids solids at room temperature always possess a solid lipid matrix? Int. J. Pharm., 115, 129-131.
3. Costa, P., & Lobo, J. M. S. (2001). Modeling and comparison of dissolution profiles. Eur. J. Pharm. Sci., 13, 123-133.
4. Jenning, V., Hildebrand, G. E., Gysler, A., Muller, R. H., Schafer Korting, M., & Gohla, S. (1999). Solid lipid nanoparticles (SLN) for topical application: Occlusive properties. Proc. Int. Symp. Control. Rel. Bioact. Mater., 26, 405-406.
5. Jenning, V., Thünemann, A. F., & Gohla, S. H. (2000). Characterisation of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids. Int. J. Pharm., 199, 167-177.
6. Jenning, V., Mader, K., & Gohla, S. H. (2000). Solid lipid nanoparticles (SLN) based on binary mixtures of liquid and solid lipids: A 1H NMR study. Int. J. Pharm., 205, 15-21.
7. Kobayashi, D., Matsuzawa, T., Sugibayashi, K., Morimoto, Y., Kobayashi, M., & Kimura, M. (1993). Feasibility of use of several cardiovascular agents in transdermal therapeutic systems with l-menthol-ethanol system on hairless rat and human skin. Biol. Pharm. Bull., 16, 254-258.
8. Komatsu, H., Kitajima, A., & Okada, S., (1995). Pharmaceutical characterization of commercially available intravenous fat emulsions: Estimation of average particle size, size distribution and surface potential using photon correlation spectroscopy. Chem. Pharm. Bull., 43, 1412-1415.
9. Levy, M. Y., Schutze, W., Fuhrer, C., & Benita, S. (1994). Characterization of diazepam submicron emulsion interface: Role of oleic acid. J. Microencapsul., 11, 79-92.
10. Mehnert, W., & Mader, K. (2001). Solid lipid nanoparticles production, characterization and applications. Adv. Drug Deliv. Rev., 47, 165-196.
11. Muller, R. H., & Dingler, A. (1998). The next generation after the liposomes: Solid lipid nanoparticles (SLN, Lipopearls) as dermal carriers in cosmetics. Eurocosmetics, 7/8, 19-26.
12. Muller, R. H., Lippacher, A., & Gohla, S. (2000a). Solid-liquid (semi-solid) lipid particles and method of producing highly concentrated lipid particle dispersions, German Patent Application 199 45 203.
13. Muller, R. H., Mehnert, W., Lucks, J. S., Schwarz, C., Zur Muhlen, A., Weyhers, H., Freitas, C., & Ruhl, D. (1995). Solid lipid nanoparticles (SLN) - An alternative colloidal carrier system for controlled drug delivery. Eur. J. Biopharm., 41, 62-69.
14. Muller, R. H., Ruhl, D., Runge, S., Schulze-Forster, K., & Mehnert, W. (1997). Cytotoxicity of solid lipid nanoparticles as a function of the lipid matrix and the surfactant. Pharm. Res., 14, 458-462.
15. Muller, R. M., Mader, K., Lippacher, A., & Jenning, V. (2000b). Festflüssige (halbfeste) Lipidpartikel und Verfahren zur Herstellung hochkonzentrierter Lipidpartikel-dispersionen, PCT/EP00/04565.
16. Radke, M. (2003). Grundlegende Untersuchungen zur Arzneistoffinkorporation - freisetzung und Struktur von SLN and NLC. PhD thesis, Freie Universität Berlin, Germany.
17. Saravanan, M., Bhaskar, K., Srinivasa Rao, G., & Dhanaraju, M. D. (2003). Ibuprofen loaded ethylcellulose/polystyrene microspheres: An approach to get prolonged drug release with reduced burst effect and low ethylcellulose content. J. Microencapsul., 20, 289-302.
18. Schwarz, C., & Mehnert, W. (1999). Solid lipid nanoparticles (SLN) for the controlled drug delivery. II. Drug incorporation and physicochemical characterization, J. Microencapsul., 16, 205-213.
19. Suwanpiodokkul, N., Thongnopnua, P., & Umprayan, K. (2004). Transdermal delivery of zidovudine (AZT): The effects of vehicles, enhancers and polymer membranes on permeation across cadaver pig skin. AAPS Pharm Sci Tech., 5, 1-7.
20. de Vringer, T. (1992). Topical preparation containing a suspension of solid lipid particles, European Patent. No. 91200664.
21. Westesen, K., Siekmann, B., & Koch, M. H. J. (1993). Investigations on the physical state of the lipid nanoparticles by synchrotron radiation X-ray diffraction. Int. J. Pharm., 93, 189-199.
22. Wissing, S. A., Lippacher, A., & Muller, R. H. (2001). Investigations on the occlusive properties of solid lipid nanoparticles (SLN). J. Cosmet. Sci., 52, 313-323.