Ibuprofen-loaded ethylcellulose/polystyrene microspheres: An approach to get prolonged drug release with reduced burst effect and low ethylcellulose content

Journal of Microencapsulation

Volumn 20, Issue 3, 2003, Pages 289-302

  Saravanan, M ^a   Bhaskar, K ^a   Srinivasa Rao, G ^a   Dhanaraju, M D ^a  

^a VELS INSTITUTE OF SCIENCE   (India)

Author keywords

Burst effect; Ethylcellulose; Ibuprofen; Microspheres; Polystyrene; Release

Indexed keywords

ETHYL CELLULOSE; IBUPROFEN; MICROSPHERE; POLYSTYRENE;

ARTICLE; CHEMICAL COMPOSITION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG RELEASE; IN VITRO STUDY; INFRARED SPECTROSCOPY; MICROENCAPSULATION; SCANNING ELECTRON MICROSCOPY; THERMOGRAPHY;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CALORIMETRY, DIFFERENTIAL SCANNING; CELLULOSE; DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; HUMANS; IBUPROFEN; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; POLYSTYRENES; SPECTROPHOTOMETRY, INFRARED;

EID: 0038784424     PISSN: 02652048     EISSN: None     Source Type: Journal    
DOI: 10.1080/0265204031000093087     Document Type: Article

References (15)

1. ABUBAKR, O. and JUN, S. Z., 2000, Captopril floating and/or bioadhesive tablets: design and release kinetics. Drug Development and Industrial Pharmacy, 26, 965-969.
2. ARABI, H., HASHEMI, S. A. and FOOLADI, M., 1996, Microencapsulation of allopurinol by solvent evaporation and controlled release investigation of drugs. Journal of Microencapsulation, 13, 527-535.
3. CARTER, S. J., 1986, Tutorial Pharmacy (New Delhi, India: CBS Publishers).
4. COSTA, P. and LOBO, J. M. S., 2001, Modeling and comparison of dissolution profiles. European Journal of Pharmaceutical Sciences, 13, 123-133.
5. DEASY, P. B., 1984, Microencapsulation and related drug processes (New York: Marcel Dekker).
6. DUBERNET, C., BENOIT, J. P., PEPPAS, N. A. and PUISIEUX, F., 1990, Ibuprofen-loaded ethylcellulose microspheres: release studies and analysis of the matrix structure through the Higuchi model. Journal of Microencapsulation, 7, 555-565.
7. KISLALIOGLU, M. S., KHAN, M. A., BLOUNT, C., GOETTSCH, R. W. and BOLTON, S., 1991, Physical characterization and dissolution properties of ibuprofen eudragit coprecipitates. Journal of Pharmaceutical Sciences, 80, 799.
8. LIN, W. J. and WU, T. L., 1999, Modification of the initial release of a highly water-soluble drug from ethylcellulose microspheres. Journal of Microencapsulation, 16, 639-646.
9. MAHMOUD, M. G., HOSSEIN, Z. and LOUIS, A. L., 1990, Preparation of controlled release anticancer agents I: 5-fluorouracil-ethylcellulose microspheres. Journal of Microencapsulation, 7, 447-454.
10. SHOBHA RANI, K. N., GOUNDALKAR, A. G. and PRAKASAM, K., 1994, Preparation and evaluation of microspheres of diclofenac sodium. Indian Journal of Pharmaceutical Sciences, 56, 45-50.
11. SUDIP, K. D., 1991, In vitro dissolution profile of the theophylline loaded ethyl cellulose microspheres prepared by emulsification solvent evaporation. Drug Development and Industrial Pharmacy, 17, 2521-2528.
12. TAMILVANAN, S. and SA, B., 2000, Studies on in vitro release behaviour of indomethacin loaded polystyrene microparticles. International Journal of Pharmaceutics, 201, 187-197.
13. THANOO, B. C., SUNNY, M. C. and JAYAKRISHNAN, A., 1993, Controlled release of oral drugs from cross-linked polyvinylalcohol microspheres. Journal of Pharmacy and Pharmacology, 45, 16-20.
14. WEIB, G., KNOCH, A., LAICHER, A., STANISLAUS, F. and DANIELS, R., 1993, Influence of polymer charge density on the simple coacervation of cellulose acetate phthalate. European Journal of Pharmaceutics and Biopharmaceutics, 39, 239-243.
15. ZINUTTI, C., KEDZIEREWICZ, F., HOFFMAN, M. and MAINCENT, P., 1994, Preparation and characterization of ethylcellulose microspheres containing 5-fluorouracil. Journal of Microencapsulation, 11, 555-563.