A transcription factor regulatory cascade controls secreted aspartic protease expression in Candida albicans

Molecular Microbiology

Volumn 69, Issue 3, 2008, Pages 586-602

  Dabas, Neelam ^a   Morschhäuser, Joachim ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC PROTEINASE; BOVINE SERUM ALBUMIN; NITROGEN; TRANSCRIPTION FACTOR GATA;

ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; DOWN REGULATION; FUNGAL GENE; FUNGAL VIRULENCE; FUNGUS GROWTH; FUNGUS MUTANT; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; SAP2 GENE;

ASPARTIC ENDOPEPTIDASES; CANDIDA ALBICANS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; MUTATION; NITROGEN; OLIGOPEPTIDES; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

BOVINAE; CANDIDA ALBICANS; FUNGI;

EID: 46949084992     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2008.06297.x     Document Type: Article

References (33)

1. Banerjee, A., Ganesan, K. Datta, A. (1991) Induction of secretory acid proteinase in Candida albicans. J Gen Microbiol 137 : 2455 2461.
2. Biswas, K. Morschhäuser, J. (2005) The Mep2p ammonium permease controls nitrogen starvation-induced filamentous growth in Candida albicans. Mol Microbiol 56 : 649 669.
3. Colina, A.R., Aumont, F., Deslauriers, N., Belhumeur, P. de Repentigny, L. (1996) Evidence for degradation of gastrointestinal mucin by Candida albicans secretory aspartyl proteinase. Infect Immun 64 : 4514 4519.
4. Dabas, N. Morschhäuser, J. (2007) Control of ammonium permease expression and filamentous growth by the GATA transcription factors GLN3 and GAT1. Candida albicans. Eukaryot Cell 6 : 875 888.
5. De Bernardis, F., Arancia, S., Morelli, L., Hube, B., Sanglard, D., Schafer, W. Cassone, A. (1999) Evidence that members of the secretory aspartyl proteinase gene family, in particular SAP2, are virulence factors for Candida vaginitis. J Infect Dis 179 : 201 208.
6. Gillum, A.M., Tsay, E.Y. Kirsch, D.R. (1984) Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations. Mol Gen Genet 198 : 179 182.
7. Hube, B., Monod, M., Schofield, D.A., Brown, A.J. Gow, N.A. (1994) Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans. Mol Microbiol 14 : 87 99.
8. Hube, B., Sanglard, D., Odds, F.C., Hess, D., Monod, M., Schafer, W., et al. (1997) Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence. Infect Immun 65 : 3529 3538.
9. Kaminishi, H., Miyaguchi, H., Tamaki, T., Suenaga, N., Hisamatsu, M., Mihashi, I., et al. (1995) Degradation of humoral host defense by Candida albicans proteinase. Infect Immun 63 : 984 988.
10. Köhler, G.A., White, T.C. Agabian, N. (1997) Overexpression of a cloned IMP dehydrogenase gene of Candida albicans confers resistance to the specific inhibitor mycophenolic acid. J Bacteriol 179 : 2331 2338.
11. Lerner, C.G. Goldman, R.C. (1993) Stimuli that induce production of Candida albicans extracellular aspartyl proteinase. J Gen Microbiol 139 : 1643 1651.
12. Liao, W.L., Ramon, A.M. Fonzi, W.A. (2008) GLN3 encodes a global regulator of nitrogen metabolism and virulence of C. albicans. Fungal Genet Biol 45 : 514 526.
13. Limjindaporn, T., Khalaf, R.A. Fonzi, W.A. (2003) Nitrogen metabolism and virulence of Candida albicans require the GATA-type transcriptional activator encoded by. Gat1 Mol Microbiol 50 : 993 1004.
14. Magasanik, B. Kaiser, C.A. (2002) Nitrogen regulation in Saccharomyces cerevisiae. Gene 290 : 1 18.
15. Martinez, P. Ljungdahl, P.O. (2005) Divergence of Stp1 and Stp2 transcription factors in Candida albicans places virulence factors required for proper nutrient acquisition under amino acid control. Mol Cell Biol 25 : 9435 9446.
16. Marzluf, G.A. (1997) Genetic regulation of nitrogen metabolism in the fungi. Microbiol Mol Biol Rev 61 : 17 32.
17. Millon, L., Manteaux, A., Reboux, G., Drobacheff, C., Monod, M., Barale, T. Michel-Briand, Y. (1994) Fluconazole-resistant recurrent oral candidiasis in human immunodeficiency virus-positive patients: persistence of Candida albicans strains with the same genotype. J Clin Microbiol 32 : 1115 1118.
18. Morschhäuser, J., Virkola, R., Korhonen, T.K. Hacker, J. (1997) Degradation of human subendothelial extracellular matrix by proteinase-secreting Candida albicans. FEMS Microbiol Lett 153 : 349 355.
19. Naglik, J.R., Challacombe, S.J. Hube, B. (2003) Candida albicans secreted aspartyl proteinases in virulence and pathogenesis. Microbiol Mol Biol Rev 67 : 400 428.
20. Odds, F.C. (1988) Candida and Candidosis: A Review and Bibliography. London : Bailliere Tindallm.
21. Park, Y.N. Morschhäuser, J. (2005) Tetracycline-inducible gene expression and gene deletion in Candida albicans. Eukaryot Cell 4 : 1328 1342.
22. Remold, H., Fasold, H. Staib, F. (1968) Purification and characterization of a proteolytic enzyme from Candida albicans. Biochim Biophys Acta 167 : 399 406.
23. Reuß, O. Morschhäuser, J. (2006) A family of oligopeptide transporters is required for growth of Candida albicans on proteins. Mol Microbiol 60 : 795 812.
24. Reuß, O., Vik, Å., Kolter, R. Morschhäuser, J. (2004) The SAT1 flipper, an optimized tool for gene disruption in Candida albicans. Gene 341 : 119 127.
25. Ross, I.K., De Bernardis, F., Emerson, G.W., Cassone, A. Sullivan, P.A. (1990) The secreted aspartate proteinase of Candida albicans: physiology of secretion and virulence of a proteinase-deficient mutant. J Gen Microbiol 136 : 687 694.
26. Rüchel, R. (1981) Properties of a purified proteinase from the yeast Candida albicans. Biochim Biophys Acta 659 : 99 113.
27. Staib, F. (1965) Serum-proteins as nitrogen source for yeastlike fungi. Sabouraudia 4 : 187 193.
28. Staib, F. (1969) Proteolysis and pathogenicity of Candida albicans strains. Mycopathol Mycol Appl 37 : 345 348.
29. Staib, P., Kretschmar, M., Nichterlein, T., Hof, H. Morschhäuser, J. (2000) Differential activation of a Candida albicans virulence gene family during infection. Proc Natl Acad Sci USA 97 : 6102 6107.
30. Staib, P., Kretschmar, M., Nichterlein, T., Hof, H. Morschhäuser, J. (2002) Host versus in vitro signals and intrastrain allelic differences in the expression of a Candida albicans virulence gene. Mol Microbiol 44 : 1351 1366.
31. Staib, P., Lermann, U., Blass-Warmuth, J., Degel, B., Würzner, R., Monod, M., et al. (2008) Tetracycline-inducible expression of individual secreted aspartic proteases in Candida albicans allows isoenzyme-specific inhibitor screening. Antimicrob Agents Chemother 52 : 146 156.
32. Watts, H.J., Cheah, F.S., Hube, B., Sanglard, D. Gow, N.A. (1998) Altered adherence in strains of Candida albicans harbouring null mutations in secreted aspartic proteinase genes. FEMS Microbiol Lett 159 : 129 135.
33. White, T.C. Agabian, N. (1995) Candida albicans secreted aspartyl proteinases: isoenzyme pattern is determined by cell type, and levels are determined by environmental factors. J Bacteriol 177 : 5215 5221.