Altered adherence in strains of Candida albicans harbouring null mutations in secreted aspartic proteinase genes

FEMS Microbiology Letters

Volumn 159, Issue 1, 1998, Pages 129-135

  Watts, H J ^a   Cheah, F S H ^a   Hube, B ^a   Sanglard, D ^a   Gow, N A R ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Adherence; Aspartate proteinase; Candida albicans; Virulence

Indexed keywords

ASPARTIC PROTEINASE;

ADHESION; ARTICLE; CANDIDA ALBICANS; CELL ADHESION; CHEEK MUCOSA; CONTROLLED STUDY; ENZYME RELEASE; FUNGUS MUTATION; GENE MUTATION; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; YEAST CELL;

ASPARTIC ENDOPEPTIDASES; BIOCOMPATIBLE MATERIALS; CANDIDA ALBICANS; CELL ADHESION; COLLAGEN; DRUG COMBINATIONS; EPITHELIAL CELLS; GENES, FUNGAL; HUMANS; LAMININ; MUTATION; PEPSTATINS; POLYLYSINE; PROTEASE INHIBITORS; PROTEOGLYCANS; SUBSTRATE SPECIFICITY; VIRULENCE;

CANDIDA ALBICANS; FUNGI; MYXOGASTRIA;

EID: 0032007999     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(97)00559-4     Document Type: Article

References (32)

1. Odds, F.C. (1994) Candida species and virulence. ASM News 60, 313-318.
2. Cutler, J.E. (1991) Putative virulence factors of Candida albicans. Annu. Rev. Microbiol. 45, 187-218.
3. Gow, N.A.R. (1996) Candida albicans: morphogenesis and pathogenesis. Jpn. J. Med. Mycol. 37, 49-58.
4. Lo, H.-J., Köhler, J.R., DiDomenico, B., Loebenberg, D., Cacciapuoti, A., and Fink, G.R. (1997) Nonfilamentous C. albicans mutants are avirulent. Cell 90, 9399-949.
5. Staib, F. (1969) Proteolysis and pathogenicity of Candida albicans strains. Mycopathol. Mycol. Appl. 37, 345-348.
6. Hube, B. (1996) Candida albicans secreted aspartyl proteinases. Curr. Top. Med. Mycol. 7, 55-69.
7. Rüchel, R. (1981) Properties of a purified proteinase from the yeast, Candida albicans. Biochem. Biophys. Acta 659, 99-113.
8. Smolenski, G., Sullivan, A., Cutfield, S.M. and Cutfield, J.F. (1997) Analysis of secreted aspartic proteinases from Candida albicans: purification and characterization of individual Sap1, Sap2 and Sap3 isoenzymes. Microbiology 143, 349-356.
9. Davies, D.R. (1990) The structure and function of aspartic proteinases. Annu. Rev. Biophys. Chem. 19, 189-215.
10. Monod, M., Tongi, G., Hube, B. and Sanglard, D. (1994) Multiplicity of genes encoding secreted aspartyl proteinases in Candida species. Mol. Microbiol. 13, 357-368.
11. Hube, B., Monod, M., Schofield, D.A., Brown, A.J.P. and Gow, N.A.R. (1994) Expression of seven members of the gene family encoding aspartyl proteinases in Candida albicans. Mol. Microbiol. 14, 87-99.
12. White, T.C. and Agabian, N. (1995) Candida albicans secreted aspartic proteinases: isoenzyme pattern is determined by cell type, levels are determined by environmental factors. J. Bacteriol. 177, 5215-5221.
13. MacDonald, F. and Odds, F.C. (1983) Virulence for mice of a proteinase-secreting strain of Candida albicans and a proteinase deficient mutant. J. Gen. Microbiol. 129, 431-438.
14. Kwon-Chung, K.J., Lehman, D., Good, C. and Magee, P.T. (1985) Genetic evidence for role of extracellular proteinase in virulence of Candida albicans. Infect. Immun. 49, 571-575.
15. Hube, B. Sanglard, D., Odds, F.C., Hess, D., Monod, M., Schäfer, W., Brown, A.P.J. and Gow, N.A.R. (1997) Disruption of each of the secreted aspartyl proteinase genes, SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence. Infect. Immun. 65, 3529-3538.
16. Sanglard, D., Hube, D., Monod, M., Odds, F.C. and Gow, N.A.R. (1997) Deletion of the secretory aspartyl protease genes SAP4, SAP5 and SAP6 of Candida albicans causes attenuated virulence. Infect. Immun. 65, 3539-3546.
17. Borg, M. and Rüchel, R. (1988) Expression of extracellular acid proteinase by proteolytic Candida spp. during experimental infection of oral mucosa. Infect. Immun. 56, 626-631.
18. El-Magharabi, E.A., Dixon, D.M. and Burnett, J.W. (1990) Characterisation of Candida albicans epidermolytic proteases and their role in yeast-cell adherence to keratinocytes. Clin. Exp. Dermatol. 15, 183-191.
19. Ollert, M.W., Sohnchen, R., Korting, H.C., Ollert, U., Brautigam, S. and Brautigam, W. (1993) Mechanisms of adherence of Candida albicans to cultured human epidermal keratinocytes. Infect. Immun. 61, 4560-4568.
20. Fonzi, W.A. and Irwin, M.Y. (1993) Isogenic strain construction and gene mapping in Candida albicans. Genetics 134, 717-728.
21. Douglas, L.J., Houston, J.G. and McCourtie, J. (1981) Adherence of Candida albicans to human buccal epithelial cells after growth on different carbon sources. FEMS Microbiol. Lett. 12, 241-243.
22. Kimura, L.H. and Pearsall, N.N. (1978) Adherence of Candida albicans to human buccal epithelial cells. Infect. Immun. 21, 64-68.
23. Calderone, R.A. (1993) Recognition between Candida albicans and host cells. Trends Microbiol. 1, 55-58.
24. Hostetter, M.K. (1994) Interactions of Candida albicans with eukaryotic cells. ASM News 60, 370-374.
25. Hazen, K.C., Brawner, D.L., Riesselman, M.H., Jutila, M.A. and Cutler, J.E. (1991) Differential adherence of hydrophobic and hydrophilic Candida albicans yeast cells to mouse tumors. Infect. Immun. 59, 907-912.
26. Jones, L. and O'Shea, P. (1994) The electrostatic nature of the cell surface of Candida albicans: a role in adhesion. Exp. Mycol. 18, 11-120.
27. Klotz, S.A. (1994) The contribution of electrostatic forces to the process of adherence of Candida albicans yeast cells to substrates. FEMS Microbiol. Lett. 257-262.
28. McCourtie, J. and Douglas, L. (1985) Unequal distribution of adhesins within populations of Candida albicans. FEMS Microbiol. Lett. 27, 111-115.
29. Lerner, C.G. and Goldman, R.C. (1993) Stimuli that induce production of Candida albicans extracellular aspartyl proteinase. J. Gen. Microbiol. 139, 1643-1651.
30. Ray, T.L. and Payne, C.D. (1988) Scanning electron microscopy of epidermal adherence and cavitation in murine candidiasis: A role for Candida acid proteinase. Infect. Immun. 56, 1942- 1949.
31. Marciniszyn, J., Hartsuck, J.A. and Tang, J. (1976) Mode of inhibition of acid proteases by pepstatin. J. Biol. Chem. 251, 7088-7094.
32. Hobden, C., Teevon, C., Jones, L. and O'Shea, P. (1995) Hydrophobic properties of the cell surface of Candida albicans: a role in aggregation. Microbiology 141, 1875-1881.