Phosphorylation of protein phosphatase 2Cζ by c-Jun NH 2-terminal kinase at Ser92 attenuates its phosphatase activity

Biochemistry

Volumn 47, Issue 27, 2008, Pages 7248-7255

  Awano, Kenjiro ^a   Amano, Kazutaka ^a   Nagaura, Yuko ^a   Kanno, Shin Ichiro ^a   Echigo, Seishi ^a   Tamura, Shinri ^a   Kobayashi, Takayasu ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; CHEMICAL REACTIONS; MAMMALS;

CELLULAR FUNCTIONS; FAMILY MEMBERS; GENE PRODUCTS; GERM CELLS; MAMMALIAN CELLS; PROTEIN PHOSPHATASE (PP); PROTEIN PHOSPHATASE 2C (PP2C);

PHOSPHORYLATION;

ALANINE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2CZETA; SERINE; STRESS ACTIVATED PROTEIN KINASE; THREONINE; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1;

AMINO ACID SUBSTITUTION; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME REPRESSION; GERM CELL; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MUTATION; NONHUMAN; OSMOTIC STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PHOSPHOSERINE;

MAMMALIA;

EID: 46849106920     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800067p     Document Type: Article

References (26)

1. Davis, R. J. (2000) Signal transduction by the JNK group of MAP kinases. Cell 103, 239-252.
2. Kishimoto, K., Matsumoto, K., and Ninomiya-Tsuji, J. (2000) TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop. J. Biol. Chem. 275, 7359-7364.
3. Takeda, K., Noguchi, T., Naguro, I., and Ichijo, H. (2008) Apoptosis Signal-Regulating Kinase 1 in Stress and Immune Response. Annu. Rev. Pharmacol. Toxicol. 48, 199-255.
4. Nebreda, A. R., and Porras, A. (2000) p38 MAP kinases: Beyond the stress response. Trends Biochem. Sci. 25, 257-260.
5. Tamura, S., Li, M. G., Komaki, K., Sasaki, M., and Kobayashi, T. (2004) Roles of mammalina protein phosphatase 2C familiy members in the regulation of cellular functions. In Protein Phosphatases (Arino, J., and Alexandre, D. R., Eds.) pp91-102, Springer-Verlag, Heidelberg, Germany.
6. Tamura, S., Toriumi, S., Saito, J., Awano, K., Kudo, T. A., and Kobayashi, T. (2006) PP2C family members play key roles in regulation of cell survival and apoptosis. Cancer Sci. 97, 563-567.
7. Joshi, M., Jeoung, N. H., Popov, K. M., and Harris, R. A. (2007) Identification of a novel PP2C-type mitochondrial phosphatase. Biochem. Biophys. Res. Commun. 356, 38-44.
8. Lu, G., Ren, S., Korge, P., Choi, J., Dong, Y., Weiss, J., Koehler, C., Chen, J. N., and Wang, Y. (2007) A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development. Genes Dev. 21, 784-796.
9. Gao, T., Furnari, F., and Newton, A. C. (2005) PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol. Cell 18, 13-24.
10. Shimizu, K., Okada, M., Takano, A., and Nagai, K. (1999) SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus. FEBS Lett. 458, 363-369.
11. Das, A. K., Helps, N. R., Cohen, P. T., and Barford, D. (1996) Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 Å resolution. EMBO J. 15, 6798-6809.
12. Komaki, K., Katsura, K., Ohnishi, M., Guang Li, M., Sasaki, M., Watanabe, M., Kobayashi, T., and Tamura, S. (2003) Molecular cloning of PP2Cη, a novel member of the protein phosphatase 2C family. Biochim. Biophys. Acta 1630, 130-137.
13. Labes, M., Roder, J., and Roach, A. (1998) A novel phosphatase regulating neurite extension on CNS inhibitors. Mol. Cell. Neurosci. 12, 29-47.
14. Hanada, M., Kobayashi, T., Ohnishi, M., Ikeda, S., Wang, H., Katsura, K., Yanagawa, Y., Hiraga, A., Kanamaru, R., and Tamura, S. (1998) Selective suppression of stress-activated protein kinase pathway by protein phosphatase 2C in mammalian cells. FEBS Lett. 437, 172-176.
15. Hanada, M., Ninomiya-Tsuji, J., Komaki, K., Ohnishi, M., Katsura, K., Kanamaru, R., Matsumoto, K., and Tamura, S. (2001) Regulation of the TAK1 signaling pathway by protein phosphatase 2C. J. Biol. Chem. 276, 5753-5759.
16. Takekawa, M., Maeda, T., and Saito, H. (1998) Protein phosphatase 2Cα inhibits the human stress-responsive p38 and JNK MAPK pathways. EMBO J. 17, 4744-4752.
17. Takekawa, M., Adachi, M., Nakahata, A., Nakayama, I., Itoh, F., Tsukuda, H., Taya, Y., and Imai, K. (2000) p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation. EMBO J. 19, 6517-6526.
18. Saito, J., Toriumi, S., Awano, K., Ichijo, H., Sasaki, K., Kobayashi, T., and Tamura, S. (2007) Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cε. Biochem. J. 405, 591-596.
19. Li, M. G., Katsura, K., Nomiyama, H., Komaki, K., Ninomiya-Tsuji, J., Matsumoto, K., Kobayashi, T., and Tamura, S. (2003) Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2Cε). J. Biol. Chem. 278, 12013-12021.
20. Fiscella, M., Zhang, H., Fan, S., Sakaguchi, K., Shen, S., Mercer, W. E., Vande Woude, G. F., O'Connor, P. M., and Appella, E. (1997) Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner. Proc. Natl. Acad. Sci. U.S.A. 94, 6048-6053.
21. Tong, Y., Quirion, R., and Shen, S. H. (1998) Cloning and characterization of a novel mammalian PP2C isozyme. J. Biol. Chem. 273, 35282-35290.
22. Steinberg, G. R., Michell, B. J., van Denderen, B. J., Watt, M. J., Carey, A. L., Fam, B. C., Andrikopoulos, S., Proietto, J., Gorgun, C. Z., Carling, D., Hotamisligil, G. S., Febbraio, M. A., Kay, T. W., and Kemp, B. E. (2006) Tumor necrosis factor α-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metab. 4, 465-474.
23. Kashiwaba, M., Katsura, K., Ohnishi, M., Sasaki, M., Tanaka, H., Nishimune, Y., Kobayashi, T., and Tamura, S. (2003) A novel protein phosphatase 2C family member (PP2Cζ) is able to associate with ubiquitin conjugating enzyme 9. FEBS Lett. 538, 197-202.
24. Boyle, W. J., van der Geer, P., and Hunter, T. (1991) Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. Methods Enzymol. 201, 110-149.
25. Cheung, P. C., Campbell, D. G., Nebreda, A. R., and Cohen, P. (2003) Feedback control of the protein kinase TAK1 by SAPK2a/p38α. EMBO J. 22, 5793-5805.
26. Lysiak, J. J., Nguyen, Q. A., Kirby, J. L., and Turner, T. T. (2003) Ischemia-reperfusion of the murine testis stimulates the expression of proinflammatory cytokines and activation of c-jun N-terminal kinase in a pathway to E-selectin expression. Biol. Reprod. 69, 202-210.