Brain adenosine A2A receptor occupancy by a novel A 1/A2A receptor antagonist, ASP5854, in rhesus monkeys: Relationship to anticataleptic effect

Journal of Nuclear Medicine

Volumn 49, Issue 7, 2008, Pages 1183-1188

  Mihara, Takuma ^a   Noda, Akihiro ^a   Arai, Hiroshi ^a   Mihara, Kayoko ^a   Iwashita, Akinori ^a   Murakami, Yoshihiro ^a   Matsuya, Takahiro ^a   Miyoshi, Sosuke ^a   Nishimura, Shintaro ^a   Matsuoka, Nobuya ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

11C SCH442416; Adenosine A2A receptors; ASP5854; Catalepsy; PET

Indexed keywords

5 [5 AMINO 3 (4FLUOROPHENYL)PYRAZINE 2 YL] 1 ISOPROPYLPYRIDINE 2(1H) ONE; 5 AMINO 2 (2 FURYL) 7 [3 (4 METHOXYPHENYL)PROPYL]PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR ANTAGONIST; ASP 5854; HALOPERIDOL; SCH 442416 C 11; TRACER; 5 (5 AMINO 3 (4 FLUOROPHENYL)PYRAZIN 2 YL) 1 ISOPROPYLPRYDINE 2(1H) ONE; 5-(5-AMINO-3-(4-FLUOROPHENYL)PYRAZIN-2-YL)-1-ISOPROPYLPRYDINE-2(1H)-ONE; ADENOSINE A1 RECEPTOR; AMINOPYRIDINE DERIVATIVE; CARBON; PIPERAZINE DERIVATIVE; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CATALEPSY; CONTROLLED STUDY; DRUG EFFECT; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RHESUS MONKEY; ANIMAL; CHEMICALLY INDUCED DISORDER; CORPUS STRIATUM; DRUG ANTAGONISM; MACACA; MALE; METABOLISM; SCINTISCANNING;

AMINOPYRIDINES; ANIMALS; CARBON RADIOISOTOPES; CATALEPSY; CORPUS STRIATUM; HALOPERIDOL; MACACA MULATTA; MALE; PIPERAZINES; POSITRON-EMISSION TOMOGRAPHY; PYRAZOLES; PYRIMIDINES; RECEPTOR, ADENOSINE A1; RECEPTOR, ADENOSINE A2A;

EID: 46749156971     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.108.051474     Document Type: Article

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