Herbal medicine, Hachimi-jio-gan, and its component cinnamomi cortex activate the peroxisome proliferator-activated receptor alpha in renal cells

Endocrine Journal

Volumn 55, Issue 3, 2008, Pages 529-533

  Monden, Tsuyoshi ^a   Hosoya, Takeshi ^b   Nakajima, Yasuyo ^b   Kishi, Mikiko ^b   Satoh, Teturou ^b   Hashimoto, Koshi ^b   Kasai, Kikuo ^a   Yamada, Masanobu ^b   Mori, Masatomo ^b  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

Cinnamomi cortex; Hachimi jio gan; PPAR

Indexed keywords

ANDROGEN RECEPTOR; CELL NUCLEUS RECEPTOR; CINNAMON EXTRACT; ESTROGEN RECEPTOR; HACHIMIJIOGAN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RETINOID X RECEPTOR; THYROID HORMONE RECEPTOR;

ACONITI; ALISMATIS RHIZOMA; ANIMAL CELL; ARTICLE; CINNAMON; CONTROLLED STUDY; DIOSCOREA RHIZOMA; DNA RESPONSIVE ELEMENT; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; GENETIC TRANSFECTION; HERBAL MEDICINE; HOELEN; HUMAN; HUMAN CELL; KIDNEY CELL; MALE; NONHUMAN; ORNI FRUCTUS; PAEONIA SUFFRUTICOSA; REHMANNIA ROOT; TRADITIONAL MEDICINE; YAM;

ANIMALS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; DRUGS, CHINESE HERBAL; HUMANS; KIDNEY; LIGANDS; ORGAN SPECIFICITY; PLANT EXTRACTS; PPAR ALPHA; TRANS-ACTIVATION (GENETICS); TRANSFECTION;

EID: 46749153029     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.K07E-101     Document Type: Article

References (21)

1. Yokozawa T, Yamabe N, Cho EJ, Nakagawa T, Oowada S (2003) A study on the effects to diabetic nephropathy of Hachimi-jio-gan in rats. Nephron Exp Nephrol 97: e38-e48.
2. Yamabe N, Kang KS, Goto E, Tanaka T, Yokozawa T (2007) Beneficial effect of corni fructus, a constituent of Hachimi-jio-gan, on advanced glycation end-product-mediated renal injury in streptozotocin-treated diabetic rats. Biol Pharm Bull 30: 520-526.
3. Yamabe N, Yokozawa T (2006) Activity of Chinese prescription Hachimi-jio-gan against renal damage in the Otsuka Long-Evans Tokushima fatty rat: a model of human type 2 diabetes mellitus. J Pharm Pharmacol 58: 535-545.
4. Nakagawa T, Yokozawa T, Yamabe N, Rhyn DY, Goto H, Shimada Y, Shibahara N (2005) Long-term treatment with Hachimi-jio-gan attenuates kidney damage in spontaneously diabetic WBN/Kob rats. J Pharm Pharmacol 57: 1205-1212.
5. Hirotani Y, Ikeda T, Yamamoto K, Kurokawa N (2007) Effects of Hachimi-jio-gan (Ba-Wei-Huang-Wan) on hyperglycemia in streptozotocin-induced diabetic rats. Bio Pharm Bull 30: 1015-1020.
6. Yamabe N, Yokozawa T, Kim HY, Cho EL (2005) Protective effect of Hachimi-jio-gan against renal failure in a subtotal nephrectomy rat model. J Pharm Pharmacol 57: 1637-1644.
7. Hirokawa S, Nose M, Amagaya S, Oyama T, Ogihara Y (1993) Protective effect of hachimi-jio-gan, an oriental herbal medicinal mixture, against cerebral anoxia. J Ethnopharmacol 40: 201-206.
8. Yamada K, Yagi G, Kanba S (2005) Effectiveness of herbal medicine (Rokumigan and Hachimijiogan) for fatigue or loss of energy in patients with partial remitted major depressive disorder. Psychiatry and Clinical Neurosciences 59: 610-612.
9. Iwasaki K, Kobayashi S, Chimura Y, Taguchi M, Inose K, Cho S, Akiba T, Arai H, Cyong J-C, Sasaki H (2004) A randomized, double-blind, placebo-eontrolled clinical trial of the Chinese herbal medicine "ba wei di huang wan" in the treatment of dementia. JAGS 52: 1518-1521.
10. Otani S, Usuki S, Iwasaki H, Inoue S, Yamashita K (1991) Successful treatment of a hyperprolactinemic infertile woman with a pituitary microadenoma using hachimijiogan. Am J Chin Med 19: 145-154.
11. Yoshida H, Kusukawa R, Watanabe N, Ohtsuki G, Sakamoto T, Haranaka R (1985) The effects of Ba-wei-wan (hachimijiogan) on plasma levels of high density lipoprotein-cholesterol and lipoperoxide in aged individuals. Am J Chin Med 13: 71-76.
12. Monden T, Nakajima Y, Hashida T, Ishii S, Tomaru T, Shibusawa N, Hashimoto K, Satoh T, Yamada M, Mori M, Kasai K (2006) Expression of thyroid hormone receptor isoforms down-regulated by thyroid hormone in human medulloblastoma cells. Endocr J 53: 181-187.
13. Cheng JT, Liu IM, Chi TC, Su HC, Chang CG (2001) metoformin-like effects of Quei Fu Huang Wan, a Chi-nese herbal mixture, on streptozotocin-induced diabetic rat. Horm Metab Res 33: 727-732.
14. Matsuda H, Matsuda R, Fukuda S, Shiomoto H, Kubo M. (1987) Anti-thrombic actions of 70% of methanolic extract and cinnamic aldehyde from cinnamomi cortex. Chem Pharm Bull (Tokyo) 35: 1275-1280.
15. Kubo M, Ma S, Wu J, Matsuda H (1996) Anti-inflammatory activities of 70% methanolic extract from Cinnamomi Cortex. Biol Pharm Bull 19: 1041-1045.
16. Kwon KB, Kim EK, Jeong ES, Lee YH, Lee YR, Park JW, Ryu DG, Park BH (2006) Cortex cinnamomi extract prevents streptozotocin- and cytokine-induced β-cell damage by inhibiting NF-kB. World J Gastroenterol 12: 4331-4337.
17. Tien ES, Hannon DB, Thompson JT, Vanden Heuvel JP (2006) Examination of ligand-dependent coactivator recruitment by peroxisome proliferators-activated receptor-α (PPARa). PPAR Research: 1-9.
18. Kim HY, Yokozawa T, Cho EJ, Yamabe N (2004) Protective effects of the Chinese prescription Hachimi-jio-gan against diabetic oxidative stress. J Pharm Pharmacol 56: 1299-1305.
19. Tachibana K, Anzai N, Ueda C, Katayama T, Kirino T, Takahashi R, Yamasaki D, Ishimoto K, Tanaka T, Hamakubo T, Ueda Y, Arai H, Sakai J, Kodama T, Doi T (2006) Analysis of PPAR alpha function inhuman kidney cell using siRNA. Nucleic Acids Symposium Series 50: 257-258.
20. Park CW, Kim HW, Ko SH, Chung HW, Lim SW, Yang CW, Chang YS, Sugawara A, Guan YF, Breyer MD (2006) Accelerated diabetic nephropathy in mice lacking the peroxisome proliferators-activated receptor α. Diabetes 55: 885-893.
21. Park CW, Zhang Y, Zhang X, Wu J, Chen L, Cha DR, Su D, Hwang M-T, Fan X, Davis L, Striker G, Zheng F, Breyer M, Guan Y (2006) PPARa agonist fenofi-brate improves diabetic nephropathy in dh/db mice. Kidney Int 69: 1511-1517.