Characterization of the effects and potential mechanisms leading to increased megakaryocytic differentiation under mild hyperthermia

Stem Cells and Development

Volumn 17, Issue 3, 2008, Pages 483-493

  Pineault, Nicolas ^a,b   Boucher, Jean François ^a   Cayer, Marie Pierre ^a   Palmqvist, Lars ^c   Boyer, Lucie ^a   Lemieux, Réal ^a,b   Proulx, Chantal ^b  

^a HÉMA QUÉBEC   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

^c SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 9; PLATELET DERIVED GROWTH FACTOR A; PLATELET DERIVED GROWTH FACTOR B; PLATELET DERIVED GROWTH FACTOR BB; STEM CELL FACTOR; THYROID PEROXIDASE; TRANSCRIPTION FACTOR;

ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL GROWTH; CELL MATURATION; CELL VIABILITY; CONTROLLED STUDY; GENE EXPRESSION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HYPERTHERMIA; MEGAKARYOCYTE; MICROARRAY ANALYSIS; POLYPLOIDY; PRIORITY JOURNAL; TEMPERATURE ACCLIMATIZATION; TEMPERATURE SENSITIVITY;

CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; CYTOKINES; FETAL BLOOD; GENE EXPRESSION REGULATION; HEAT-SHOCK RESPONSE; HUMANS; MEGAKARYOCYTES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PLATELET-DERIVED GROWTH FACTOR; POLYPLOIDY; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; TEMPERATURE; TRANSCRIPTION FACTORS;

EID: 46749113054     PISSN: 15473287     EISSN: None     Source Type: Journal    
DOI: 10.1089/scd.2007.0149     Document Type: Article

References (39)

1. Norol F, N Vitrat, E Cramer, J Guichard, SA Burstein, W Vainchenker and N Debili. (1998). Effects of cytokines on platelet production from blood and marrow CD34+ cells. Blood 91:830-843.
2. Tajika K, K Ikebuchi, K Inokuchi, S Hasegawa, K Dan, S Sekiguchi, T Nakahata and S Asano. (1998). IL-6 and SCF exert different effects on megakaryocyte maturation. Br J Haematol 100:105-111.
3. van den Oudenrijn S, M de Haas, J Calafat, CE van der Schoot and AE von dem Borne. (1999). A combination of megakaryocyte growth and development factor and interleukin-1 is sufficient to culture large numbers of megakaryocytic progenitors and megakaryocytes for transfusion purposes. Br J Haematol 106:553-563.
4. Bertolini F, M Battaglia, P Pedrazzoli, GA Da Prada, A Lanza, D Soligo, L Caneva, B Sarina, S Murphy, T Thomas and GR della Cuna. (1997). Megakaryocytic progenitors can be generated ex vivo and safely administered to autologous peripheral blood progenitor cell transplant recipients. Blood 89:2679-2688.
5. Su RJ, K Li, M Yang, XB Zhang, KS Tsang, TF Fok, CK Li and PM Yuen. (2001). Platelet-derived growth factor enhances ex vivo expansion of megakaryocytic progenitors from human cord blood. Bone Marrow Transplant 27: 1075-1080.
6. Kie JH, WI Yang, MK Lee, TJ Kwon, YH Min, HO Kim, HS Ahn, SA Im, HL Kim, HY Park, KH Ryu, WS Chung, MH Shin, YJ Jung, SY Woo, HK Park and JY Seoh. (2002). Decrease in apoptosis and increase in polyploidization of megakaryocytes by stem cell factor during ex vivo expansion of human cord blood CD34+ cells using thrombopoietin. Stem Cells 20:73-79.
7. Cortin V, A Garnier, N Pineault, R Lemieux, L Boyer and C Proulx. (2005). Efficient in vitro megakaryocyte maturation using cytokine cocktails optimized by statistical experimental design. Exp Hematol 33:1182-1191.
8. Avecilla ST, K Hattori, B Heissig, R Tejada, F Liao, K Shido, DK Jin, S Dias, F Zhang, TE Hartman, NR Hackett, RG Crystal, L Witte, DJ Hicklin, P Bohlen, D Eaton, D Lyden, F de Sauvage and S Rafii. (2004). Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Nat Med 10:64-71.
9. Fox NE and K Kaushansky. (2005). Engagement of integrin alpha4beta1 enhances thrombopoietin-induced mega-karyopoiesis. Exp Hematol 33:94-99.
10. Leven RM and F Tablin. (1992). Extracellular matrix stimulation of guinea pig megakaryocyte proplatelet formation in vitro is mediated through the vitronectin receptor. Exp Hematol 20:1316-1322.
11. Leven RM. (1995). Differential regulation of integrin-mediated proplatelet formation and megakaryocyte spreading. J Cell Physiol 163:597-607.
12. Saulle E, R Riccioni, E Pelosi, M Stafness, G Mariani, G De Tuglie, C Peschle and U Testa. (2006). In vitro dual effect of arsenic trioxide on hemopoiesis: inhibition of erythropoiesis and stimulation of megakaryocytic maturation. Blood Cells Mol Dis 36:59-76.
13. Peled T, E Landau, E Prus, AJ Treves, A Nagler and E Fibach. (2002). Cellular copper content modulates differentiation and self-renewal in cultures of cord blood-derived CD34+ cells. Br J Haematol 116:655-661.
14. McAdams TA, WM Miller and ET Papoutsakis. (1997). Variations in culture pH affect the cloning efficiency and differentiation of progenitor cells in ex vivo haemopoiesis. Br J Haematol 97:889-895.
15. Mostafa SS, WM Miller and ET Papoutsakis. (2000). Oxygen tension influences the differentiation, maturation and apoptosis of human megakaryocytes. Br J Haematol 111:879-889.
16. Audet J, CL Miller, CJ Eaves and JM Piret. (2002). Common and distinct features of cytokine effects on hematopoietic stem and progenitor cells revealed by dose-response surface analysis. Biotechnol Bioeng 80:393-404.
17. Goliaei B and Z Soheili. (1999). Behaviour of heat-treated bone marrow cells in long-term bone marrow cultures. Int J Hyperthermia 15:409-418.
18. Proulx C, N Dupuis, I St-Amour, L Boyer and R Lemieux. (2004). Increased megakaryopoiesis in cultures of CD34-enriched cord blood cells maintained at 39 degrees C. Biotechnol Bioeng 88:675-680.
19. Proulx C, L Boyer, DR Hurnanen and R Lemieux. (2003). Preferential ex vivo expansion of megakaryocytes from human cord blood CD34+-enriched cells in the presence of thrombopoietin and limiting amounts of stem cell factor and Flt-3 ligand. J Hematother Stem Cell Res 12:179-188.
20. Perez-Iratxeta C, G Palidwor, CJ Porter, NA Sanche, MR Huska, BP Suomela, E M Muro, PM Krzyzanowski, E Hughes, PA Campbell, MA Rudnicki and MA Andrade. (2005). Study of stem cell function using microarray experiments. FEBS Lett 579:1795-1801.
21. Irizarry RA, B Hobbs, F Collin, YD Beazer-Barclay, KJ Antonellis, U Scherf and TP Speed. (2003). Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4:249-264.
22. Livak KJ and TD Schmittgen. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402-408. 23. Schmittgen TD. (2001). Real-time quantitative PCR. Methods 25:383-385.
23. Wierenga PK, R Setroikromo, G Kamps, HH Kampinga and E Vellenga. (2002). Peripheral blood stem cells differ from bone marrow stem cells in cell cycle status, repopulating potential, and sensitivity toward hyperthermic purging in mice mobilized with cyclophosphamide and granulocyte colony-stimulating factor. J Hematother Stem Cell Res 11:523-532.
24. Yang M, CN Chesterman and BH Chong. (1995). Recombinant PDGF enhances megakaryocytopoiesis in vitro. Br J Haematol 91:285-289.
25. Westermark B, L Claesson-Welsh and CH Heldin. (1989). Structural and functional aspects of the receptors for platelet-derived growth factor. Prog Growth Factor Res 1:253-266.
26. Pang L, MJ Weiss and M Poncz. (2005). Megakaryocyte biology and related disorders. J Clin Invest 115:3332-3338
27. Zhu J and SG Emerson. (2002). Hematopoietic cytokines, transcription factors and lineage commitment. Oncogene 21:3295-3313.
28. Moriyama Y, M Narita, K Sato, M Urushiyama, S Koyama, H Hirosawa, K Kishi, M Takahashi, K Takai and A Shibata. (1986). Application of hyperthermia to the treatment of human acute leukemia: purging human leukemic progenitor cells by heat. Blood 67:802-804.
29. Wierenga PK and AW Konings. (1993). Studies on the hyperthermic sensitivity of the murine hematopoietic stem cell compartment. I. Heat effects on clonogenic stem cells and progenitors. Exp Hematol 21:608-613.
30. Laszlo A. (1992). The effects of hyperthermia on mammalian cell structure and function. Cell Prolif 25:59-87.
31. Laszlo A and A Venetianer. (1998). Heat resistance in mammalian cells: lessons and challenges. Ann N Y Acad Sci 851:169-178.
32. Mattia G, F Vulcano, L Milazzo, A Barca, G Macioce, A Giampaolo and HJ Hassan. (2002). Different ploidy levels of megakaryocytes generated from peripheral or cord blood CD34+ cells are correlated with different levels of platelet release. Blood 99:888-897.
33. Eisbacher M, ML Holmes, A Newton, PJ Hogg, LM Khachigian, M Crossley and BH Chong. (2003). Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding. Mol Cell Biol 23:3427-3441.
34. Sayer MS, PA Tilbrook, A Spadaccini, E Ingley, MK Sarna, JH Williams, NC Andrews and SP Klinken. (2000). Ectopic expression of transcription factor NF-E2 alters the phenotype of erythroid and monoblastoid cells. J Biol Chem 275:25292-25298.
35. Athanasiou M, PA Clausen, GJ Mavrothalassitis, XK Zhang, DK Watson and DG Blair. (1996). Increased expression of the ETS-related transcription factor FLI-1/ERGB correlates with and can induce the megakaryocytic phenotype. Cell Growth Differ 7:1525-1534.
36. Yamaguchi Y, LI Zon, SJ Ackerman, M Yamamoto and T Suda. (1998). Forced GATA-1 expression in the murine myeloid cell line M1: induction of c-Mpl expression and megakaryocytic/erythroid differentiation. Blood 91:450-457.
37. LaIuppa JA, ET Papoutsakis and WM Miller. (1998). Oxygen tension alters the effects of cytokines on the megakaryocyte, erythrocyte, and granulocyte lineages. Exp Hematol 26:835-843.
38. Mostafa SS, ET Papoutsakis and WM Miller. (2001). Oxygen tension modulates the expression of cytokine receptors, transcription factors, and lineage-specific markers in cultured human megakaryocytes. Exp Hematol 29:873-883.
39. Chen Z, M Hu and RA Shivdasani. (2007). Expression analysis of primary mouse megakaryocyte differentiation and its application in identifying stage-specific molecular markers and a novel transcriptional target of NF-E2. Blood 109:1451-1459.