MHC class II antigen presentation and immunological abnormalities due to deficiency of MHC class II and its associated genes

Experimental and Molecular Pathology

Volumn 85, Issue 1, 2008, Pages 40-44

  Chen, Xinjian ^a   Jensen, Peter E ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Antigen presentation; B lymphocytes; Dendritic cells; HLA DM; HLA DO; Invariant chain; MHC class II

Indexed keywords

HLA DM ANTIGEN; HLA DO ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; AUTOIMMUNITY; BARE LYMPHOCYTE SYNDROME; CELL MATURATION; COMMON VARIABLE IMMUNODEFICIENCY; FLOW CYTOMETRY; GENE DELETION; HUMAN; IMMUNE DEFICIENCY; IMMUNOPATHOLOGY; NONHUMAN; REGULATORY MECHANISM; REVIEW;

ANIMALS; ANTIGEN PRESENTATION; B-LYMPHOCYTES; DENDRITIC CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-D ANTIGENS; HUMANS; IMMUNE SYSTEM DISEASES; LYMPHOCYTE ACTIVATION; MICE;

ANIMALIA;

EID: 46749105074     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2008.03.011     Document Type: Review

References (56)

1. Alfonso C., Liljedahl M., Winqvist O., Surh C.D., Peterson P.A., Fung-Leung W.P., and Karlsson L. The role of H2-O and HLA-DO in major histocompatibility complex class II-restricted antigen processing and presentation. Immunol. Rev. 172 (1999) 255-266
2. Alfonso C., Han J.O., Williams G.S., and Karlsson L. The impact of H2-DM on humoral immune responses. J. Immunol. 167 (2001) 6348-6355
3. Alfonso C., Williams G.S., Han J.O., Westberg J.A., Winqvist O., and Karlsson L. Analysis of H2-O influence on antigen presentation by B cells. J. Immunol. 171 (2003) 2331-2337
4. Alfonso C., Williams G.S., and Karlsson L. H2-O influence on antigen presentation in H2-E-expressing mice. Eur. J. Immunol. 33 (2003) 2014-2021
5. Bakke O., and Dobberstein B. MHC class II-associated invariant chain contains a sorting signal for endosomal compartments. Cell 63 (1990) 707-716
6. Battegay M., Bachmann M.F., Burhkart C., Viville S., Benoist C., Mathis D., Hengartner H., and Zinkernagel R.M. Antiviral immune responses of mice lacking MHC class II or its associated invariant chain. Cell. Immunol. 167 (1996) 115-121
7. Bikoff E.K., Huang L.Y., Episkopou V., van Meerwijk J., Germain R.N., and Robertson E.J. Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression. J. Exp. Med. 177 (1993) 1699-1712
8. Chan S.H., Cosgrove D., Waltzinger C., Benoist C., and Mathis D. Another view of the selective model of thymocyte selection. Cell 73 (1993) 225-236
9. Chang C.H., and Flavell R.A. Class II transactivator regulates the expression of multiple genes involved in antigen presentation. J. Exp. Med. 181 (1995) 765-767
10. Chang C.H., Guerder S., Hong S.C., van Ewijk W., and Flavell R.A. Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression. Immunity 4 (1996) 167-178
11. Chen X., and Jensen P.E. The expression of HLA-DO (H2-O) in B lymphocytes. Immunol. Res. 29 (2004) 19-28
12. Chen X., Laur O., Kambayashi T., Li S., Bray R.A., Weber D.A., Karlsson L., and Jensen P.E. Regulated expression of human histocompatibility leukocyte antigen (HLA)-DO during antigen-dependent and antigen-independent phases of B cell development. J. Exp. Med. 195 (2002) 1053-1062
13. Chen X., Reed-Loisel L.M., Karlsson L., and Jensen P.E. H2-O expression in primary dendritic cells. J. Immunol. 176 (2006) 3548-3556
14. Choi E.Y., Jung K.C., Park H.J., Chung D.H., Song J.S., Yang S.D., Simpson E., and Park S.H. Thymocyte-thymocyte interaction for efficient positive selection and maturation of CD4 T cells. Immunity 23 (2005) 387-396
15. Clausen B.E., Waldburger J.M., Schwenk F., Barras E., Mach B., Rajewsky K., Forster I., and Reith W. Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice. Immunity 8 (1998) 143-155
16. Cosgrove D., Gray D., Dierich A., Kaufman J., Lemeur M., Benoist C., and Mathis D. Mice lacking MHC class II molecules. Cell 66 (1991) 1051-1066
17. Denzin L.K., and Cresswell P. HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading. Cell 82 (1995) 155-165
18. Denzin L.K., Sant'Angelo D.B., Hammond C., Surman M.J., and Cresswell P. Negative regulation by HLA-DO of MHC class II-restricted antigen processing. Science (New York, NY 278 (1997) 106-109
19. Fallas J.L., Tobin H.M., Lou O., Guo D., Sant'Angelo D.B., and Denzin L.K. Ectopic expression of HLA-DO in mouse dendritic cells diminishes MHC class II antigen presentation. J. Immunol. 173 (2004) 1549-1560
20. Fischer A. Human primary immunodeficiency diseases: a perspective. Nat. Immunol. 5 (2004) 23-30
21. Fung-Leung W.P., Surh C.D., Liljedahl M., Pang J., Leturcq D., Peterson P.A., Webb S.R., and Karlsson L. Antigen presentation and T cell development in H2-M-deficient mice. Science (New York, NY 271 (1996) 1278-1281
22. Gondre-Lewis T.A., Moquin A.E., and Drake J.R. Prolonged antigen persistence within nonterminal late endocytic compartments of antigen-specific B lymphocytes. J. Immunol. 166 (2001) 6657-6664
23. Grusby M.J., Johnson R.S., Papaioannou V.E., and Glimcher L.H. Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice. Science (New York, NY 253 (1991) 1417-1420
24. Herve M., Isnardi I., Ng Y.S., Bussel J.B., Ochs H.D., Cunningham-Rundles C., and Meffre E. CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance. J. Exp. Med. 204 (2007) 1583-1593
25. Hornell T.M., Burster T., Jahnsen F.L., Pashine A., Ochoa M.T., Harding J.J., Macaubas C., Lee A.W., Modlin R.L., and Mellins E.D. Human dendritic cell expression of HLA-DO is subset specific and regulated by maturation. J. Immunol. 176 (2006) 3536-3547
26. Klein C., Lisowska-Grospierre B., LeDeist F., Fischer A., and Griscelli C. Major histocompatibility complex class II deficiency: clinical manifestations, immunologic features, and outcome. J. Pediatr. 123 (1993) 921-928
27. Klein C., Cavazzana-Calvo M., Le Deist F., Jabado N., Benkerrou M., Blanche S., Lisowska-Grospierre B., Griscelli C., and Fischer A. Bone marrow transplantation in major histocompatibility complex class II deficiency: a single-center study of 19 patients. Blood 85 (1995) 580-587
28. Koonce C.H., Wutz G., Robertson E.J., Vogt A.B., Kropshofer H., and Bikoff E.K. DM loss in k haplotype mice reveals isotype-specific chaperone requirements. J. Immunol. 170 (2003) 3751-3761
29. Kropshofer H., Vogt A.B., Thery C., Armandola E.A., Li B.C., Moldenhauer G., Amigorena S., and Hammerling G.J. A role for HLA-DO as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules. EMBO J. 17 (1998) 2971-2981
30. Li W., Kim M.G., Gourley T.S., McCarthy B.P., Sant'Angelo D.B., and Chang C.H. An alternate pathway for CD4 T cell development: thymocyte-expressed MHC class II selects a distinct T cell population. Immunity 23 (2005) 375-386
31. Liljedahl M., Winqvist O., Surh C.D., Wong P., Ngo K., Teyton L., Peterson P.A., Brunmark A., Rudensky A.Y., Fung-Leung W.P., et al. Altered antigen presentation in mice lacking H2-O. Immunity 8 (1998) 233-243
32. Madsen L., Labrecque N., Engberg J., Dierich A., Svejgaard A., Benoist C., Mathis D., and Fugger L. Mice lacking all conventional MHC class II genes. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 10338-10343
33. Marinova T., Altankova I., Dimitrova D., and Pomakov Y. Presence of HLA-DR immunopositive cells in human fetal thymus. Arch. Physiol. Biochem. 109 (2001) 74-79
34. Markowitz J.S., Auchincloss Jr. H., Grusby M.J., and Glimcher L.H. Class II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient mice. Proc. Natl. Acad. Sci. U. S. A. 90 (1993) 2779-2783
35. Martin W.D., Hicks G.G., Mendiratta S.K., Leva H.I., Ruley H.E., and Van Kaer L. H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell 84 (1996) 543-550
36. Martinic M.M., van den Broek M.F., Rulicke T., Huber C., Odermatt B., Reith W., Horvath E., Zellweger R., Fink K., Recher M., et al. Functional CD8+ but not CD4+ T cell responses develop independent of thymic epithelial MHC. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 14435-14440
37. Medzhitov R. Toll-like receptors and innate immunity. Nat. Rev. 1 (2001) 135-145
38. Miyazaki T., Wolf P., Tourne S., Waltzinger C., Dierich A., Barois N., Ploegh H., Benoist C., and Mathis D. Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway. Cell 84 (1996) 531-541
39. Nagarajan U.M., Lochamy J., Chen X., Beresford G.W., Nilsen R., Jensen P.E., and Boss J.M. Class II transactivator is required for maximal expression of HLA-DOB in B cells. J. Immunol. 168 (2002) 1780-1786
40. Nekrep N., Fontes J.D., Geyer M., and Peterlin B.M. When the lymphocyte loses its clothes. Immunity 18 (2003) 453-457
41. Notarangelo L., Casanova J.L., Fischer A., Puck J., Rosen F., Seger R., and Geha R. Primary immunodeficiency diseases: an update. J. Allergy Clin. Immunol. 114 (2004) 677-687
42. Park S.H., Bae Y.M., Kim T.J., Ha I.S., Kim S., Chi J.G., and Lee S.K. HLA-DR expression in human fetal thymocytes. Hum. Immunol. 33 (1992) 294-298
43. Reith W., and Mach B. The bare lymphocyte syndrome and the regulation of MHC expression. Annu. Rev. Immunol. 19 (2001) 331-373
44. Riese R.J., Wolf P.R., Bromme D., Natkin L.R., Villadangos J.A., Ploegh H.L., and Chapman H.A. Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading. Immunity 4 (1996) 357-366
45. Sakaguchi S., and Powrie F. Emerging challenges in regulatory T cell function and biology. Science (New York, NY 317 (2007) 627-629
46. Salzer U., and Grimbacher B. Common variable immunodeficiency: the power of co-stimulation. Semin. Immunol. 18 (2006) 337-346
47. Seamons A., Perchellet A., and Goverman J. Endogenous myelin basic protein is presented in the periphery by both dendritic cells and resting B cells with different functional consequences. J. Immunol. 177 (2006) 2097-2106
48. Singh N., and Van Kaer L. Unexpected reactivities of T cells selected by a single MHC-peptide ligand. J. Immunol. 163 (1999) 3583-3591
49. Surh C.D., Lee D.S., Fung-Leung W.P., Karlsson L., and Sprent J. Thymic selection by a single MHC/peptide ligand produces a semidiverse repertoire of CD4+ T cells. Immunity 7 (1997) 209-219
50. Topilski I., Harmelin A., Flavell R.A., Levo Y., and Shachar I. Preferential Th1 immune response in invariant chain-deficient mice. J. Immunol. 168 (2002) 1610-1617
51. van Ham M., van Lith M., Lillemeier B., Tjin E., Gruneberg U., Rahman D., Pastoors L., van Meijgaarden K., Roucard C., Trowsdale J., et al. Modulation of the major histocompatibility complex class II-associated peptide repertoire by human histocompatibility leukocyte antigen (HLA)-DO. J. Exp. Med. 191 (2000) 1127-1136
52. Viville S., Neefjes J., Lotteau V., Dierich A., Lemeur M., Ploegh H., Benoist C., and Mathis D. Mice lacking the MHC class II-associated invariant chain. Cell 72 (1993) 635-648
53. Weber D.A., Evavold B.D., and Jensen P.E. Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM. Science (New York, NY 274 (1996) 618-620
54. Wehr C., Kivioja T., Schmitt C., Ferry B., Witte T., Eren E., Vlkova M., Hernandez M., Detkova D., Bos P.R., et al. The EUROclass trial: defining subgroups in common variable immunodeficiency. Blood (2007)
55. Westerheide S.D., Louis-Plence P., Ping D., He X.F., and Boss J.M. HLA-DMA and HLA-DMB gene expression functions through the conserved S-X-Y region. J. Immunol. 158 (1997) 4812-4821
56. Wong P., and Rudensky A.Y. Phenotype and function of CD4+ T cells in mice lacking invariant chain. J. Immunol. 156 (1996) 2133-2142