BCR-ABL1 alters SDF-1α-mediated adhesive responses through the β2 integrin LFA-1 in leukemia cells

Blood

Volumn 111, Issue 10, 2008, Pages 5182-5186

  Chen, Ying Yu ^a   Malik, Mobeen ^a   Tomkowicz, Brian E ^a   Collman, Ronald G ^a   Ptasznik, Andrzej ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b 522C Johnson Pavilion   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; BCR ABL1 PROTEIN; BETA2 INTEGRIN; CHEMOKINE RECEPTOR CXCR4; EPITOPE; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PROTEIN KINASE LYN; STROMAL CELL DERIVED FACTOR 1ALPHA; UNCLASSIFIED DRUG; LYN PROTEIN-TYROSINE KINASE; PROTEIN TYROSINE KINASE; STROMAL CELL DERIVED FACTOR 1;

ARTICLE; BONE MARROW CELL; CELL LYSATE; CELL MIGRATION; CELL POPULATION; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; CELL ADHESION; CELL CULTURE; CELL MOTION; LEUKEMIA; METABOLISM; PATHOLOGY; PHYSIOLOGY;

CELL ADHESION; CELL MOVEMENT; CELLS, CULTURED; CHEMOKINE CXCL12; FUSION PROTEINS, BCR-ABL; HUMANS; LEUKEMIA; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 46749102195     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2007-10-117705     Document Type: Article

References (15)

1. Aiuti A, Turchetto L, Cota M, et al. Human CD34(+) cells express CXCR4 and its ligand stromal cell-derived factor-1. Implications for infection by T-cell tropic human immunodeficiency virus. Blood. 1999;94:62-73.
2. Zou YR, Kottmann AH, Kuroda M, Taniuchi I, Littman DR. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature. 1998;393:595-599.
3. Geay JF, Buet D, Zhang Y, et al. p210BCR-ABL inhibits SDF-1 chemotactic response viaalteration of CXCR4 signaling and down-regulation of CXCR4 expression. Cancer Res. 2005;65:2676- 2683.
4. Salgia R, Quackenbush E, Lin J, et al. The BCR/ ABL oncoprotein alters the chemotactic response to stromal-derived factor-1. Blood. 1999;94:4233- 4246.
5. Ptasznik A, Urbanowska E, Chinta S, et al. Crosstalk between BCR/ABL oncoprotein and CXCR4 signaling through a Src family kinase in human leukemia cells. J Exp Med. 2002;196:667- 678.
6. Ginsberg MH, Du X, Plow EF. Inside-out integrin signalling. Curr Opin Cell Biol. 1992;4:766-771.
7. Nakata Y, Tomkowicz B, Gewirtz AM, Ptasznik A. Integrin inhibition through Lyn-dependentcross talk from CXCR4 chemokine receptors in normal human CD34+ marrow cells. Blood. 2006;107:4234-4239.
8. Ptasznik A, Nakata Y, Kalota A, Emerson SG, Gewirtz AM. Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug resistant, BCR-ABL(+) leukemia cells. Nat Med. 2004;10:1187-1189.
9. Arias-Salgado EG, Lizano S, Sarkar S, Brugge JS, Ginsberg MH, Shattil SJ. Src kinase activation by direct interaction with the integrin betacytoplasmic domain. Proc Natl Acad Sci U S A. 2003;100:13298-13302.
10. Bazzoni G, Carlesco N, Griffin JD, Hemler ME. Bcr/Abl expression stimulates integrin function in hematopopietic cell lines. J Clin Invest. 1996;98:521-528.
11. Ruoslahti E. Fibronectin and its receptors. Annu Rev Biochem. 1988;57:375-413.
12. Greeberger JS. The hematopoietic microenvironment. Crit Rev Oncol Hematol. 1991;11:65-84.
13. Hu Y, Liu Y, Pelletier S, et al. Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia. Nat Genet. 2004;36:440-444.
14. Ptasznik A, Traynor-Kaplan A, Bokoch GM. G protein-coupled chemoattractant receptors regulate Lyn tyrosine kinase-Shc adapter protein signaling complexes. J Biol Chem. 1995;270:19969-19973.
15. O'Laughlin-Brunner B, Radosevic N, Taylor M, et al. Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells. Blood. 2001;98:343-350.