Design, synthesis and preliminary screening of novel 3-(2-N,N-dimethylaminoethylthio) indole derivatives as potential 5-HT6 receptor ligands

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 23, Issue 3, 2008, Pages 302-312

  Kambhampati, Ramasastri ^a   Konda, Jagadishbabu ^a   Reballi, Veena ^a   Shinde, Anil K ^a   Dubey, Pramod K ^b   Nirogi, Ramakrishna V S ^a  

^a SUVEN LIFE SCIENCES LTD   (India)

^b JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

Author keywords

5 HT6 receptor ligands; Molecular modeling; N aryl sulfonyl indoles; SAR; Synthesis

Indexed keywords

1 (2 BROMOBENZENESULFONYL) 3 DIMETHYLAMINOETHYLTHIO 1H INDOLE; 1 (2 BROMOBENZENESULFONYL) 3 DIMETHYLAMINOETHYLTHIO 5 BROMO 1H INDOLE; 1 (2 BROMOBENZENESULFONYL) 3 DIMETHYLAMINOETHYLTHIO 5 CHLORO 1H INDOLE; 1 (2 BROMOBENZENESULFONYL) 3 DIMETHYLAMINOETHYLTHIO 5 FLUORO 1H INDOLE; 1 (2 BROMOBENZENESULFONYL) 3 DIMETHYLAMINOETHYLTHIO 5 METHOXY 1H INDOLE; 1 (3 TRIFLUOROBENZENESULFONYL) 3 DIMETHYLAMINOETHYLTHIO 5 BROMO 1H INDOLE; 1 (3 TRIFLUOROMETHYLBENZENESULFONYL) 3 DIMETHYLAMINOETHYLTHIO 1H INDOLE; 1 (3 TRIFLUOROMETHYLBENZENESULFONYL) 3 DIMETHYLAMINOETHYLTHIO 5 CHLORO 1H INDOLE; 1 (4 BROMOBENZENESULFONYL) 3 DIMETHYLAMINOETHYLTHIO 5 FLUORO 1H INDOLE; 1 (4 FLUOROBENZENESULFONYL) 3 DIMETHYLAMINOETHYLTHIO 1H INDOLE; 1 (4 FLUOROBENZENESULFONYL) 3 DIMETHYLAMINOETHYLTHIO 5 BROMO 1H INDOLE; 1 (4 FLUOROBENZENESULFONYL) 3 DIMETHYLAMINOETHYLTHIO 5 FLUORO 1H INDOLE; 1 (4 FLUOROBENZENESULFONYL) 3 DIMETHYLAMINOETHYLTHIO 5 METHOXY 1H INDOLE; 1 (4 ISOPROPYLBENZENESULFONYL) 3 DIMETHYLAMINOETHYLTHIO 5 BROMO 1H INDOLE; 1 (4 ISOPROPYLBENZENESULFONYL) 3 DIMETHYLAMINOETHYLTHIO 5 CHLORO 1H INDOLE; 1 (4 ISOPROPYLBENZENESULFONYL) 3 DIMETHYLAMINOETHYLTHIO 5 FLUORO 1H INDOLE; 1 (4 METHOXYBENZENESULFONYL) 3 DIMETHYLAMINOETHYLTHIO 5 FLUORO 1H INDOLE; 1 (4 METHYLBENZENESULFONYL) 3 DIMETHYLAMINOETHYLTHIO 1H INDOLE; 1 (BENZENESULFONYL) 3 DIMETHYLAMINOETHYLTHIO 1H INDOLE; 1 BENZENESULFONYL 5 METHOXY N,N DIMETHYLTRYPTAMINE; 3 (2 N,N DIMETHYLAMINOETHYLTHIO)INDOLE DERIVATIVE; INDOLE DERIVATIVE; LIGAND; N ARYLSULFONYL 3 (2 N,N DIMETHYLAMINOETHYLTHIO)INDOLE DERIVATIVE; RADIOLIGAND; SEROTONIN 6 ANTAGONIST; SEROTONIN 6 RECEPTOR; SULFUR; TRYPTAMINE DERIVATIVE; UNINDEXED DRUG;

ARTICLE; BINDING AFFINITY; DRUG DESIGN; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR MODEL; PRIORITY JOURNAL;

HUMANS; INDOLES; LIGANDS; MODELS, MOLECULAR; RADIOLIGAND ASSAY; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 46649119059     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360701526936     Document Type: Article

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