Protective role of nebivolol in hydroxyl radical induced injury

Journal of Cardiovascular Pharmacology

Volumn 38, Issue SUPPL. 3, 2002, Pages

  Janssen, P M L ^a   Zeitz, O ^a   Rahman, A ^a   Hasenfuss, G ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Beta blocker; Calcium sensitivity; OFR; Rabbit; Skinned fiber

Indexed keywords

CALCIUM ION; HYDROXYL RADICAL; NEBIVOLOL; OXYGEN RADICAL; PROPRANOLOL; BENZOPYRAN DERIVATIVE; BETA 1 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM; ETHANOLAMINE DERIVATIVE; HYDROGEN PEROXIDE; OXIDIZING AGENT;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DESENSITIZATION; DRUG EFFECT; DRUG MECHANISM; HEART FAILURE; HEART MUSCLE CONTRACTILITY; HEART PROTECTION; MYOFILAMENT; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RABBIT; REPERFUSION INJURY; SARCOPLASMIC RETICULUM; STUNNED HEART MUSCLE; ANIMAL; COMPARATIVE STUDY; DRUG ANTAGONISM; FEMALE; HEART CONTRACTION; HEART MUSCLE; HUMAN; IN VITRO STUDY; MALE; METABOLISM; MICROFILAMENT; PHYSIOLOGY; ULTRASTRUCTURE;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; BENZOPYRANS; CALCIUM; ETHANOLAMINES; FEMALE; HUMANS; HYDROGEN PEROXIDE; HYDROXYL RADICAL; MALE; MICROFILAMENTS; MYOCARDIAL CONTRACTION; MYOCARDIUM; OXIDANTS; PROPRANOLOL; RABBITS; RECEPTORS, ADRENERGIC, BETA-1;

EID: 0036135328     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200112003-00004     Document Type: Article

References (41)

1. Molecular and cellular mechanisms of myocardial stunning
2. Enhancement of recovery of myocardial function by oxygen free-radical scavengers after reversible regional ischemia
3. Superoxide dismutase plus catalase improve contractile function in the canine model of the "stunned myocardium"
4. Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone
5. Effects of exogenous free radicals on electromechanical function and metabolism in isolated rabbit and guinea pig ventricle: Implications for ischemia and reperfusion injury
6. Xanthine oxidoreductase activity in perfused hearts of various species, including humans
7. Glycolytic inhibition and calcium overload as consequences of exogenously generated free radicals in rabbit hearts
8. Breakdown and release of myofilament proteins during ischemia and ischemia-reperfusion in rat hearts: Identification of degradation products and effects on the pCa-force relation
9. Study of the mechanisms of hydrogen peroxide and hydroxyl free radical-induced cellular injury and calcium overload in cardiac myocytes
10. Effects of oxygen free radicals in isolated cardiac myocytes from guinea-pig ventricle: Electrophysiological studies
11. Selective effects of oxygen free radicals on excitation-contraction coupling in ventricular muscle: Implication for the mechanism of stunned myocardium
12. 2+-ATPase function by direct attack on the ATP binding site
13. Role of troponin-I proteolysis in the pathogenesis of stunned myocardium
14. Gene expression of antioxidative enzymes in the human heart: Increased expression of catalase in the end-stage failing heart
15. Attenuation of dysfunction in the postischemic "stunned" myocardium by dimethylthiorea
16. N-2-Mercaptopro-pionyglycine improves recovery of myocardial function after reversible regional ischemia
17. Inhibition of sarcolemmal carbon-centered free-radical formation by propranolol
18. Propranolol as xanthine oxidase inhibitor: Implications for antioxidant activity
19. Free radical scavenging and inhibition of lipid peroxidation by β-blockers and by agents that interfere with calcium metabolism
20. Free radical scavenging properties of β-adrenoceptor blockers are not relevant for cardioprotection in isolated rabbit hearts
21. Carvedilol, a new vasodilator and beta adrenoceptor antagonist, is an antioxidant and free radical scavenger
22. Carvedilol, a new beta-adrenoceptor antagonist and vasodilator antihypertensive drug, inhibits superoxide release from human neutrophils
23. Carvedilol, a new beta adrenoceptor blocker and free radical scavenger, attenuates myocardial ischemia-reperfusion injury in hypercholesterolemic rabbits
24. Protective effects of carvedilol in the myocardium
25. Effect of beta-blockers on free radical-induced cardiac contractile function
26. Transient and sustained impacts of hydroxyl radicals on sarcoplasmic reticulum function: Protective effects of nebivolol
27. Protection of human left ventricular myocardium from cutting injury with 2,3-butanedione monoxime
28. Tension development and sarcomere length in rat cardiac trabeculae: Evidence of length-dependent activation
29. Lack of effect of isoproterenol on unloaded velocity of sarcomere shortening in rat cardiac trabeculae
30. 2+ transient in rat cardiac trabeculae
31. Measurement and characterization of post-ischemic free radical generation in the isolated perfused heart
32. Glycolytic inhibition and calcium overload as consequences of exogenously generated free radicals in rabbit hearts
33. Computer programs for calculating total from specified free or free from specified total ionic concentrations in aqueous solutions containing multiple metals and ligands
34. Protein kinase A does not alter unloaded velocity of sarcomere shortening in skinned rat cardiac trabeculae
35. An algorithm for least squares estimation of non-linear parameters
36. Fitting curves to data using nonlinear regression: A practical and nonmathematical review
37. Nebivolol vasodilates human forearm vasculature: Evidence for an L-arginine/NO-dependent mechanism
38. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure
39. Pharmacological and hemodynamic profile of nebivolol, a chemically novel, potent, and selective beta 1-adrenergic antagonist
40. Effects of D-nebivolol and L-nebivolol on left ventricular systolic and diastolic function: Comparison with D-L-nebivolol and atenolol
41. Nebivolol in the treatment of cardiac failure: A double-blind controlled clinical trial