The relation between serum erythropoietin level and severity of disease and mortality in patients with chronic heart failure

Acta Cardiologica

Volumn 63, Issue 3, 2008, Pages 297-302

  Avkaroǧullari, Mahir ^a   Bozkurt, Abdi ^a,b   Akpinar, Onur ^a   Dönmez, Yurdaer ^a   Demirtaş, Mustafa ^a  

^a CUKUROVA UNIVERSITY   (Turkey)

^b University School of Medicine   (Turkey)

Author keywords

Anaemia; Erythropoietin; Heart failure; Mortality

Indexed keywords

ACETYLSALICYLIC ACID; AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIGITALIS; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; ENALAPRIL; ERYTHROPOIETIN; FUROSEMIDE; HEMOGLOBIN; NITRATE; PLACEBO; SPIRONOLACTONE; VASODILATOR AGENT;

ADULT; ANEMIA; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; CARDIOVASCULAR DISEASE; CHRONIC DISEASE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; SERUM; TRANSTHORACIC ECHOCARDIOGRAPHY;

BIOLOGICAL MARKERS; CHRONIC DISEASE; ECHOCARDIOGRAPHY; ERYTHROPOIETIN; FEMALE; FOLLOW-UP STUDIES; HEART FAILURE; HEMATOCRIT; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NATRIURETIC PEPTIDE, BRAIN; PEPTIDE FRAGMENTS; PROGNOSIS; PROTEIN PRECURSORS; SEVERITY OF ILLNESS INDEX; SURVIVAL RATE; TIME FACTORS; TURKEY;

EID: 46449097824     PISSN: 00015385     EISSN: None     Source Type: Journal    
DOI: 10.2143/AC.63.3.1020304     Document Type: Article

References (21)

1. Hunt SA, Baker DW, Chin MH, Cinquegrani MP, Feldman AM, Francis GS, Ganiats TG, Goldstein S, Gregoratos G, Jessup ML, Noble RJ, Packer M, Silver MA, Stevenson LW, Gibbons RJ, Antman EM, Alpert JS, Faxon DP, Fuster V, Jacobs AK, Hiratzka LF, Russell RO, Smith SC Jr; ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1995 Guidelines for the Evaluation and Management of Heart Failure). J Am Coll Cardiol 2001; 38: 2101-13.
2. Remme WJ, Swedberg K. Guidelines for the diagnosis and treatment of chronic heart failure. Eur Heart J 2001; 22: 1527-60.
3. Volpe M, Tritto C, Testa U, Rao MA, Martucci R, Mirante A, Enea I, Russo R, Rubattu S, Condorelli GL. Blood levels of erythropoietin in congestive heart failure and correlation with clinical, hemodynamic, and hormonal profiles. Am J Cardiol 1994; 74: 468-73.
4. Fyhrquist F, Karppinen K, Honkanen T. Saijonmaa O, Rosenlof K. High serum erythropoietin levels are normalized during treatment of congestive heart failure with enalapril. J Int Medicine 1989; 226: 257-60.
5. van der Meer P, Voors AA, Lipsic E, Smilde TD, van Gilst WH, van Veldhuisen DJ. Prognostic value of plasma ery-tropoietin on mortality with chronic heart failure. J Am Coll Cardiol 2004; 44: 63-7.
6. George J, Patal S, Wexler D, Abashidze A, Shmilovich H, Barak T, Sheps D, Keren G. Circulating erythropoietin levels and prognosis in patients with congestive heart failure: comparison with neurohormonal and inflammatory markers. Arch Int Med 2005; 165: 1304-9.
7. Al-Ahmad A, Rand WM, Manjunath G, Konstam MA, Salem DN, Levey AS, Sarnak MJ. Reduced kidney function and anemia as risk factors for mortality in patients with left ventricular dysfunction. J Am Coll Cardiol 2001; 38: 955-62.
8. McClellan WM, Flanders WD, Langston RD Jurkovitz C, Presley R. Anemia and renal insufficiency are independent risk factors for death among patients with congestive heart failure admitted to community hospitals: a population-based study. J Am Soc Nephrol 2002; 13: 1928-36.
9. Horwich TB, Fonarow GC, Hamilton MA, MacLellan WR, Borenstein J. Anemia is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with advanced heart failure. J Am Coll Cardiol 2002; 39: 1780-6.
10. Ezekowitz JA, McAlister FA, Armstrong PW. Anemia is common in heart failure and is associated with poor outcomes: insights from a cohort of 12,065 patients with new onset heart failure. Circulation 2003; 107: 223-5.
11. Silverberg D. Outcomes of anaemia management in renal insufficiency and cardiac disease. Nephrol Dial Transplant 2003; 18 Suppl 2: 7-12.
12. Adams KF, Patterson JH, Pina I, Ghali JK, Mehra MR, Oren RM. STAMINA-HFP (Study of Anemia in a Heart Failure Population) registry: rationale, design, and patient characteristics. J Card Failure 2003; 9 Suppl 1: S73.
13. Opasich C, Cazzola M, Scelsi L, De Feo S, Bosimini E, Lagioia R, Febo O, Ferrari R, Fucili A, Moratti R, Tra-marin R, Tavazzi L. Blunted erythropoietin production and defective iron supply for erythropoiesis as major causes of anemia in patients with chronic heart failure. Eur Heart J 2005; 26: 2232-7.
14. Westenbrink BD, Visser FW, Voors AA, Smilde TD, Lipsic E, Navis G, Hillege HL, van Gilst WH, van Veldhuisen DJ. Anemia in chronic heart failure is not only related to impaired renal perfusion and blunted erythropoietin production, but to fluid retention as well. Eur Heart J 2007; 28: 166-71.
15. Fazlibegovic E, Hadziomerovic M, Coric S, Babic E, Fazlibegovic F. Erythropoietin in cardiorenal anemia syndrome. Bosna J Basic Med Sci 2006; 6: 36-41.
16. Palazzuoli A, Silverberg D, Iovine F, Capobianco S, Gian-notti G, Calabro A, Campagna SM, Nuti R. Erythropoietin improves anemia, exercise tolerance and renal function and reduces B-type natriuretic peptide and hospitalization in patients with heart failure and anemia. Am Heart J 2006; 152: e9-15.
17. Voulgari PV, Kolios G, Papadopoulos GK, Katsaraki A, Seferiadis K, Drosos AA. Role of cytokines in the patho-genesis of anemia of chronic disease in rheumatoid arthritis. Clin Immunol 1999; 92: 153-60.
18. Jelkmann W. Proinflammatory cytokines lowering erythropoietin production. J Interferon Cytokine Res 1998; 18: 555-9.
19. Torre-Amione G, Kapadia S, Benedict C, Oral H, Young JB, Mann DL. Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the Studies Of Left Ventricular Dysfunction (SOLVD). J Am Coll Cardiol 1996; 27: 1201-6.
20. Klahr S. Structure and function of the kidneys. In: Wyngo-orden JB, Smith LH, Bennett JC, eds. Cecil Textbook of Medicine, Philadelphia, WB Saunders Company, 1992: 491.
21. th ed. Winrobe's Clinical Hematology, Philadelphia, Lea & Febiger, 1993: 134-57.