Synthesis and biological evaluation of bicyclic and tricyclic substituted nortropane derivatives: Discovery of a novel selective α 1D- adrenergic receptor ligand

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 21, 2004, Pages 5639-5650

  McGinty, Susan J ^a   Finch, Angela ^b   Griffith, Renate ^c   Graham, Robert M ^b   Bremner, John B ^a  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

^c UNIVERSITY OF NEWCASTLE   (Australia)

Author keywords

1 Adrenergic receptor; 3,6,6 Trisubstituted nortropanes; 6 Hydroxytropinone; Microwave assisted reactions

Indexed keywords

2 METHOXY 6ABETA (3,4 METHYLENEDIOXYPHENYL) 2,5 METHANOHEXAHYDRO 2H FURO[3,2 B]PYRROL 6ALPHA OL; 2 METHOXY 6ABETA PHENYL 2,5 METHANOHEXAHYDRO 2H FURO[3,2 B]PYRROL 6ALPHA OL; 4 (2,2,2 TRICHLOROETHOXYCARBONYL) 6ABETA (3,4 METHYLENEDIOXYPHENYL) 2,5 METHANOHEXAHYDRO 2H FURO[3,2 B]PYRROL 6AALPHA,2BETA DIOL; 4 (2,2,2 TRICHLOROETHOXYCARBONYL) 6ABETA PHENYL 2,5 METHANOHEXAHYDRO 2H FURO[3,2 B]PYRROL 6AALPHA,2BETA DIOL; 6 O TERT BUTYLDIMETHYLSILYL 8 (2,2,2 TRICHLOROETHOXYCARBONYL) 8 AZABICYCLO[3.2.1]OCTAN 3 ONE; 6ABETA (3,4 METHYLENEDIOXYPHENYL) 2,5 METHANOHEXAHYDRO 2H FURO[3,2 B]PYRROL 6AALPHA,2BETA DIOL; 6ABETA PHENYL 2,5 METHANOHEXAHYDRO 2H FURO[3,2 B]PYRROL 6AALPHA,2BETA DIOL; 6BETA (3,4 METHYLENEDIOXY) 8 AZABICYCLO[3.2.1]OCTAN 3 SPIRO 2' (1',3' DIOXOLAN) 6 OL; 6BETA (3,4 METHYLENEDIOXYPHENYL) 8 AZABICYCLO[3.2.1]OCTANE 3ALPHA,6BETA DIOL; 6BETA O TERT BUTYLDIMETHYLSILYL 8 (2,2,2 TRICHLOROETHOXYCARBONYL 8 AZABICYCLO[3.2.1] 3 SPIRO 2' (1',3' DIOXOLANE)OCTANE; 6BETA O TERT BUTYLDIMETHYLSILYL 8 METHYL 8 AZABICYCLO[3.2.1]OCTAN 3 ONE; 6BETA PHENYL 8 AZABICYCLO[3.2.1]OCTAN 3 SPIRO 2' (1',3' DIOXOLAN) 6 OL; 6BETA PHENYL 8 AZABICYCLO[3.2.1]OCTANE 3ALPHA,6BETA DIOL; 8 (2,2,2 TRICHLOROETHOXYCARBONYL) 3,3 DIMETHOXY 6BETA (3,4 METHYLENEDIOXYPHENYL) 8 AZABICYCLO[3.2.1]OCTAN 6ALPHA OL; 8 (2,2,2 TRICHLOROETHOXYCARBONYL) 3,3 DIMETHOXY 6BETA PHENYL 8 AZABICYCLO[3.2.1] 3 OXOACTAN 6 OL; 8 (2,2,2 TRICHLOROETHOXYCARBONYL) 3,3 DIMETHOXY 6BETA PHENYL 8 AZABICYCLO[3.2.1]OCTAN 6ALPHA OL; 8 (2,2,2 TRICHLOROETHOXYCARBONYL) 3,3 DIMETHOXY 8 AZABICYCLO[3.2.1]OCTAN 6 ONE; 8 (2,2,2 TRICHLOROETHOXYCARBONYL) 6ALPHA HYDROXY 6BETA (3,4 METHYLENEDIOXYPHENYL) 8 AZABICYCLO[3.2.1]OCTAN 3 ONE; 8 (2,2,2 TRICHLOROETHOXYCARBONYL) 6BETA (3,4 METHYLENEDIOXYPHENYL) 8 AZABICYCLO[3.2.1]OCTAN 3 SPIRO 2' (1',3' DIOXOLANE) 6ALPHA OL; 8 (2,2,2 TRICHLOROETHOXYCARBONYL) 6BETA (3,4 METHYLENEDIOXYPHENYL) 8 AZABICYCLO[3.2.1]OCTANE 3BETA,6ALPHA DIOL; 8 (2,2,2 TRICHLOROETHOXYCARBONYL) 6BETA HYDROXY 3,3 DIMETHOXY 8 AZABICYCLO[3.2.1]OCTANE; 8 (2,2,2 TRICHLOROETHOXYCARBONYL) 6BETA PHENYL 8 AZABICYCLO[3.2.1]OCTAN 3 SPIRO 2' (1',3' DIOXOLANE) 6ALPHA OL; 8 (2,2,2 TRICHLOROETHOXYCARBONYL) 6BETA PHENYL 8 AZABICYCLO[3.2.1]OCTANE 3BETA,6ALPHA DIOL 6ALPHA OL; 8 (2,2,2 TRICHLOROETHOXYCARBONYL) 8 AZABICYCLO[3.2.1]OCTAN 3 SPIRO 2' (1',3' DIOXOLANE) 6 ONE; 8 (2,2,2 TRICHLOROETHOXYCARBONYL) 8 AZABICYCLO[3.2.1]OCTAN 3 SPIRO 2' (1',3' DIOXOLANE) 6BETA OL; ALPHA 1 ADRENERGIC RECEPTOR; CARBONYL DERIVATIVE; NORTROPANE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; RECEPTOR AFFINITY;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; DRUG EVALUATION, PRECLINICAL; LIGANDS; NORTROPANES; PROTEIN BINDING; RECEPTORS, ADRENERGIC, ALPHA-1;

EID: 4644370830     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.07.063     Document Type: Article

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