Novel chemoselective linkage chemistry toward controlled loading of ligands to proteins through in situ real-time quantification of conjugate formation

Bioconjugate Chemistry

Volumn 15, Issue 5, 2004, Pages 1010-1020

  Flinn, Nicholas S ^a   Quibell, Martin ^a   Turnell, William G ^a   Monk, Tracy P ^b   Ramjee, Manoj K ^a  

^a Amura Therapeutics Limited   (United Kingdom)

^b MediVas LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LOADING; PROTEINS; QUALITY ASSURANCE; SOLUBILITY;

2-HYDROXYBENZALDEHYDES; ABSORBANCE CHANGE; CHEMICAL ATTACHMENT; CHEMOSELECTIVE; LIGAND MOLECULES; QUATERNARY AMINES; REAL-TIME QUANTIFICATION; SIMPLE++; STATE OF THE ART; SYNTHETIC VACCINES;

LIGANDS;

AMINE; BENZALDEHYDE; HYDRAZONE DERIVATIVE; LIGAND; SALICYLALDEHYDE; VACCINE;

ABSORPTION; ARTICLE; CONJUGATION; COVALENT BOND; CROSS LINKING; PH; QUALITY CONTROL; QUANTITATIVE ANALYSIS; QUATERNARY; SOLUBILITY;

EID: 4644349577     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc0499329     Document Type: Article

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