Limited influence of haemoglobin variants on Plasmodium falciparum msp1 and msp2 alleles in symptomatic malaria

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 98, Issue 5, 2004, Pages 302-310

  Mockenhaupt, Frank P ^a   Ehrhardt, Stephan ^a   Otchwemah, Rowland ^b   Eggelte, Teunis A ^c   Anemana, Sylvester D ^d   Stark, Klaus ^e   Bienzle, Ulrich ^a   Kohne, Elisabeth ^f  

^a HUMBOLDT UNIVERSITY   (Germany)

^b UNIVERSITY FOR DEVELOPMENT STUDIES   (Ghana)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d Regional Health Administration Cape Coast   (Ghana)

^e ROBERT KOCH INSTITUTE   (Germany)

^f UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

Ghana; HbC; Malaria; MOI; msp; Thalassaemia

Indexed keywords

HEMOGLOBIN C; HEMOGLOBIN S; HEMOGLOBIN VARIANT; MEROZOITE SURFACE PROTEIN 1; MEROZOITE SURFACE PROTEIN 2; MEROZOITE SURFACE PROTEIN 2, PLASMODIUM; PARASITE ANTIGEN; PROTOZOAL PROTEIN;

ALLELE; ALPHA THALASSEMIA; ARTICLE; CHILD; CONTROLLED STUDY; FEMALE; FEVER; GENOTYPE; HEMOGLOBIN DETERMINATION; HEMOGLOBINOPATHY; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALARIA CONTROL; MALARIA FALCIPARUM; MALE; MICROBIAL DIVERSITY; PARASITE IDENTIFICATION; PLASMODIUM FALCIPARUM; SYMPTOMATOLOGY; ADOLESCENT; ADULT; ANIMAL; GENETICS; HEMOGLOBIN C DISEASE; MIDDLE AGED; PARASITOLOGY; SICKLE CELL ANEMIA;

PLASMODIUM FALCIPARUM;

ADOLESCENT; ADULT; ALLELES; ALPHA-THALASSEMIA; ANEMIA, SICKLE CELL; ANIMALS; ANTIGENS, PROTOZOAN; CHILD; FEMALE; HEMOGLOBIN C DISEASE; HEMOGLOBINOPATHIES; HUMANS; MALARIA, FALCIPARUM; MALE; MEROZOITE SURFACE PROTEIN 1; MIDDLE AGED; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS;

EID: 2942655235     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trstmh.2003.10.001     Document Type: Article

References (41)

1. Agarwal A. Guindo A. Cissoko Y. Taylor J.G. Coulibaly D. Kone A. Kayentao K. Djimde A. Plowe C.V. Doumbo O. Wellems T.E. Diallo D. Hemoglobin C associated with protection from severe malaria in the Dogon of Mali, a West African population with a low prevalence of hemoglobin S Blood 96 2000 2358-2363
2. Aidoo M. Terlouw D.J. Kolczak M.S. McElroy P.D. ter Kuile F.O. Kariuki S. Nahlen B.L. Lal A.A. Udhayakumar V. Protective effects of the sickle cell gene against malaria morbidity and mortality Lancet 359 2002 1311-1312
3. Allen S.J. O'Donnell A. Alexander N.D. Alpers M.P. Peto T.E. Clegg J.B. Weatherall D.J. alpha+-thalassemia protects children against disease caused by other infections as well as malaria Proc. Natl. Acad. Sci. USA 94 1997 14736-14741
4. Allen S.J. Rowe P. Allsopp C.E. Riley E.M. Jakobsen P.H. Hill A.V. Greenwood B.M. A prospective study of the influence of alpha thalassaemia on morbidity from malaria and immune responses to defined Plasmodium falciparum antigens in Gambian children Trans. R. Soc. Trop. Med. Hyg. 87 1993 282-285
5. Allison A.C. Polymorphism and natural selection in human populations Cold Spring Harb. Symp. Quant. Biol. 29 1964 137-149
6. al-Yaman F. Genton B. Reeder J.C. Anders R.F. Smith T. Alpers M.P. Reduced risk of clinical malaria in children infected with multiple clones of Plasmodium falciparum in a highly endemic area: A prospective community study Trans. R. Soc. Trop. Med. Hyg. 91 1997 602-605
7. Ariey F. Hommel D. Le Scanf C. Duchemin J.B. Peneau C. Hulin A. Sarthou J.L. Reynes J.M. Fandeur T. Mercereau-Puijalon O. Association of severe malaria with a specific Plasmodium falciparum genotype in French Guiana J. Infect. Dis. 184 2001 237-241
8. Beck H.P. Felger I. Huber W. Steiger S. Smith T. Weiss N. Alonso P. Tanner M. Analysis of multiple Plasmodium falciparum infections in Tanzanian children during the phase III al of the malaria vaccine SPf66 J. Infect. Dis. 175 1997 921-926
9. Binka F.N. Morris S.S. Ross D.A. Arthur P. Aryeetey M.E. Patterns of malaria morbidity and mortality in children in northern Ghana Trans. R. Soc. Trop. Med. Hyg. 88 1994 381-385
10. Branch O.H. Takala S. Kariuki S. Nahlen B.L. Kolczak M. Hawley W. Lal A.A. Plasmodium falciparum genotypes, low complexity of infection, and resistance to subsequent malaria in participants in the Asembo Bay Cohort Project Infect. Immun. 69 2001 7783-7792
11. Ehrhardt S. Mockenhaupt F.P. Agana-Nsiire P. Mathieu A. Anemana S.D. Stark K. Otchwemah R.N. Bienzle U. Efficacy of chloroquine in the treatment of uncomplicated, Plasmodium falciparum malaria in northern Ghana Ann. Trop. Med. Parasitol. 96 2002 239 247
12. Fairhurst R.M. Fujioka H. Hayton K. Collins K.F. Wellems T.E. Aberrant development of Plasmodium falciparum in hemoglobin CC red cells: implications for the malaria protective effect of the homozygous state Blood 101 2003 3309-3315
13. Färnert A. Rooth I. Svensson A. Snounou G. Bjorkman A. Complexity of Plasmodium falciparum infections is consistent over time and protects against clinical disease in Tanzanian children J. Infect. Dis. 179 1999 989-995
14. Flint J. Harding R.M. Boyce A.J. Clegg J.B. The population genetics of the haemoglobinopathies Baillieres Clin. Haematol. 11 1998 1-51
15. Goel V.K. Li X. Chen H. Liu S.C. Chishti A.H. Oh S.S. Band 3 is a host receptor binding merozoite surface protein 1 during the Plasmodium falciparum invasion of erythrocytes Proc. Natl. Acad. Sci. USA 100 2003 5164-5169
16. Haldane J.B.S. The rate of mutation of human genes Hereditas 35 1949 267-272
17. Huisman T.H.J. Separation of hemoglobins and hemoglobin chains by high performance liquid chromatography J. Chromatogr. 418 1987 277-304
18. Konate L. Zwetyenga J. Rogier C. Bischoff E. Fontenille D. Tall A. Spiegel A. Trape J.F. Mercereau-Puijalon O. Variation of Plasmodium falciparum msp1 block 2 and msp2 allele prevalence and of infection complexity in two neighbouring Senegalese villages with different transmission conditions Trans. R. Soc. Trop. Med. Hyg. 93 Suppl. 1 1999 21-28
19. Kun J.F.J. Schmidt-Ott R.J. Lehman L.G. Lell B. Luckner D. Greve B. Matousek P. Kremsner P.G. Merozoite surface antigen 1 and 2 genotypes and rosetting of Plasmodium falciparum in severe and mild malaria in Lambarene, Gabon Trans. R. Soc. Trop. Med. Hyg. 92 1998 110-114
20. Kwiatkowski D. Cytokines and anti-disease immunity to malaria Res. Immunol. 142 1991 707-712
21. Lell B. May J. Schmidt-Ott R.J. Lehman L.G. Luckner D. Greve B. Matousek P. Schmid D. Herbich K. Mockenhaupt F.P. Meyer C.G. Bienzle U. Kremsner P.G. The role of red blood cell polymorphisms in resistance and susceptibility to malaria Clin. Infect. Dis. 28 1999 794-799
22. Liu Y.T. Old J.M. Miles K. Fisher C.A. Weatherall D.J. Clegg J.B. Rapid detection of alpha-thalassaemia deletions and alpha-globin gene triplication by multiplex polymerase chain reactions Br. J. Haematol. 108 2000 295-299
23. Luzzi G.A. Merry A.H. Newbold C.I. Marsh K. Pasvol G. Weatherall D.J. Surface antigen expression on Plasmodium falciparum-infected erythrocytes is modified in alpha- and beta-thalassemia J. Exp. Med. 173 1991 785-791
24. Magesa S.M. Mdira K.Y. Babiker H.A. Alifrangis M. Färnert A. Simonsen P.E. Bygbjerg I.C. Walliker D. Jakobsen P.H. Diversity of Plasmodium falciparum clones infecting children living in a holoendemic area in north-eastern Tanzania Acta Trop. 84 2002 83-92
25. Mockenhaupt F.P. Rong B. Günther M. Beck S. Till H. Kohne E. Thompson W.N. Bienzle U. Anaemia in pregnant Ghanaian women: importance of malaria, iron deficiency, and haemoglobinopathies Trans. R. Soc. Trop. Med. Hyg. 94 2000 477-483
26. Modiano D. Luoni G. Sirima B.S. Simpore J. Verra F. Konate A. Rastrelli E. Olivieri A. Calissano C. Paganotti G.M. D'Urbano L. Sanou I. Sawadogo A. Modiano G. Coluzzi M. Haemoglobin C protects against clinical Plasmodium falciparum malaria Nature 414 2001 305-308
27. Müller D.A. Charlwood J.D. Felger I. Ferreira C. do Rosario V. Smith T. Prospective risk of morbidity in relation to multiplicity of infection with Plasmodium falciparum in Sao Tome Acta Trop. 78 2001 155-162
28. Ntoumi F. Ekala M.T. Makuwa M. Lekoulou F. Mercereau-Puijalon O. Deloron P. Sickle cell trait carriage: imbalanced distribution of IgG subclass antibodies reactive to Plasmodium falciparum family-specific MSP2 peptides in serum samples from Gabonese children Immunol. Lett. 84 2002 9-16
29. Ntoumi F. Rogier C. Dieye A. Trape J.F. Millet P. Mercereau-Puijalon O. Imbalanced distribution of Plasmodium falciparum MSP-1 genotypes related to sickle-cell trait Mol. Med. 3 1997a 581-592
30. Ntoumi F. Mercereau-Puijalon O. Ossari S. Luty A. Reltien J. Georges A. Millet P. Plasmodium falciparum: sickle-cell trait is associated with higher prevalence of multiple infections in Gabonese children with asymptomatic infections Exp. Parasitol. 87 1997b 39-46
31. Ofosu-Okyere A. Mackinnon M.J. Sowa M.P. Koram K.A. Nkrumah F. Osei Y.D. Hill W.G. Wilson M.D. Arnot D.E. Novel Plasmodium falciparum clones and rising clone multiplicities are associated with the increase in malaria morbidity in Ghanaian children during the transition into the high transmission season Parasitology 123 2001 113-123
32. Owusu-Agyei S. Smith T. Beck H.P. Amenga-Etego L. Felger I. Molecular epidemiology of Plasmodium falciparum infections among asymptomatic inhabitants of a holoendemic malarious area in northern Ghana Trop. Med. Int. Health 7 2002 421-428
33. Pattanapanyasat K. Yongvanitchit K. Tongtawe P. Tachavanich K. Wanachiwanawin W. Fucharoen S. Walsh D.S. Impairment of Plasmodium falciparum growth in thalassemic red blood cells: Further evidence by using biotin labeling and flow cytometry Blood 93 1999 3116-3119
34. Robert F. Ntoumi F. Angel G. Candito D. Rogier C. Fandeur T. Sarthou J.L. Mercereau-Puijalon O. Extensive genetic diversity of Plasmodium falciparum isolates collected from patients with severe malaria in Dakar, Senegal Trans. R. Soc. Trop. Med. Hyg. 90 1996 704-711
35. Senok A.C. Li K. Nelson E.A. Arumanayagam M. Li C.K. Flow cytometric assessment of oxidant stress in age-fractionated thalassaemic trait erythrocytes and its relationship to in vitro growth of Plasmodium falciparum Parasitology 116 1998 1-6
36. Smith T. Felger I. Tanner M. Beck H.P. Premunition in Plasmodium falciparum infection: insights from the epidemiology of multiple infections Trans. R. Soc. Trop. Med. Hyg. 93 Suppl. 1 1999 59-64
37. Snounou G. Zhu X. Siripoon N. Jarra W. Thaithong S. Brown K.N. Viriyakosol S. Biased distribution of msp1 and msp2 allelic variants in Plasmodium falciparum populations in Thailand Trans. R. Soc. Trop. Med. Hyg. 93 1999 369-374
38. WHO, 1996. Assessment of therapeutic efficacy of antimalarial drugs for uncomplicated falciparum malaria in areas with intense transmission. World Health Organization, Geneva. WHO/MAL/96.1077.
39. Wilkinson R.J. Pasvol G. Host resistance to malaria runs into swampy water Trends Microbiol. 5 1997 213-215
40. Williams T.N. Weatherall D.J. Newbold C.I. The membrane characteristics of Plasmodium falciparum-infected and -uninfected heterozygous alpha(0)thalassaemic erythrocytes Br. J. Haematol. 118 2002 663-670
41. Witte A.M. Klever H.J. Brabin B.J. Eggelte T.A. Van der Kaay H.J. Alpers M.P. Field evaluation of the use of an ELISA to detect chloroquine and its metabolites in blood, urine and breast-milk Trans. R. Soc. Trop. Med. Hyg. 84 1990 521-525