Species differential stereoselective oxidation of a methylsulfide metabolite of MK-0767 [(±)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2- methoxy-N-[[(4-trifluoromethyl)phenyl]methyl]benzamide], a peroxisome proliferator-activated receptor dual agonist

Drug Metabolism and Disposition

Volumn 32, Issue 10, 2004, Pages 1061-1068

  Karanam, Bindhu V ^a   Welch, Christopher J ^a   Reddy, Vijay G ^a   Chilenski, Jennifer ^a   Biba, Mirlinda ^a   Vincent, Stella ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 5 (2,4 DIOXO 5 THIAZOLIDINYLMETHYL) 2 METHOXY N [4 (TRIFLUOROMETHYL)BENZYL]BENZAMIDE; 5 [(2,4 DIOXOTHIAZOLIDIN 5 YL)METHYL] 2 METHOXY N [[(4 TRIFLUOROMETHYL)PHENYL]METHYL]BENZAMIDE; CIMETIDINE; CYTOCHROME P450 3A4; DRUG METABOLITE; FLAVIN MONOOXYGENASE 3; KETOCONAZOLE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; POLYCLONAL ANTIBODY; SULFONE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ANIMAL TISSUE; ARTICLE; CHIRALITY; DOG; DRUG METABOLISM; DRUG OXIDATION; DRUG TRANSFORMATION; ENANTIOMER; HUMAN; HUMAN TISSUE; LIVER MICROSOME; METHYLATION; NONHUMAN; PH; PRIORITY JOURNAL; RAT; RHESUS MONKEY; RING OPENING; STEREOCHEMISTRY; SUPERCRITICAL FLUID CHROMATOGRAPHY;

ANIMALS; CELL LINE; DOGS; HUMANS; INSECTS; MACACA MULATTA; MICROSOMES, LIVER; OXIDATION-REDUCTION; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; RATS; SPECIES SPECIFICITY; STEREOISOMERISM; SULFURIC ACID ESTERS; THIAZOLES;

ANIMALIA; CANIS FAMILIARIS; MACACA MULATTA;

EID: 4644322443     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.104.000224     Document Type: Article

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